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PDB: 277 件
2DM6
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BU of 2dm6 by Molmil
Crystal structure of anti-configuration of indomethacin and leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase complex
分子名称: INDOMETHACIN, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, NADP-dependent leukotriene B4 12-hydroxydehydrogenase, ...
著者Hori, T, Ishijima, J, Yokomizo, T, Ago, H, Shimizu, T, Miyano, M, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2006-04-20
公開日2006-11-28
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of anti-configuration of indomethacin and leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase complex reveals the structural basis of broad spectrum indomethacin efficacy
J.Biochem.(Tokyo), 140, 2006
3WPG
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BU of 3wpg by Molmil
Crystal structure of mouse TLR9 in complex with inhibitory DNA4084 (form 1)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (5'-D(*CP*CP*TP*GP*GP*AP*TP*GP*GP*GP*AP*A)-3'), SULFATE ION, ...
著者Ohto, U, Shimizu, T.
登録日2014-01-11
公開日2015-02-11
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.246 Å)
主引用文献Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
Nature, 520, 2015
3W3M
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BU of 3w3m by Molmil
Crystal structure of human TLR8 in complex with Resiquimod (R848) crystal form 2
分子名称: 1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ...
著者Tanji, H, Ohto, U, Shimizu, T.
登録日2012-12-22
公開日2013-04-03
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands
Science, 339, 2013
3VJH
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BU of 3vjh by Molmil
Human PPAR GAMMA ligand binding domain in complex with JKPL35
分子名称: (2S)-2-[4-methoxy-3-({[4-(trifluoromethyl)benzoyl]amino}methyl)benzyl]pentanoic acid, Peroxisome proliferator-activated receptor gamma
著者Tomioka, D, Kuwabara, N, Hashimoto, H, Sato, M, Shimizu, T.
登録日2011-10-20
公開日2012-08-29
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献Peroxisome proliferator-activated receptors (PPARs) have multiple binding points that accommodate ligands in various conformations: phenylpropanoic acid-type PPAR ligands bind to PPAR in different conformations, depending on the subtype.
J.Med.Chem., 55, 2012
3WPI
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BU of 3wpi by Molmil
Crystal structure of mouse TLR9 in complex with inhibitory DNA_super
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (5'-D(*CP*CP*TP*CP*AP*AP*TP*AP*GP*GP*GP*TP*GP*AP*GP*GP*GP*G)-3'), Toll-like receptor 9
著者Ohto, U, Shimizu, T.
登録日2014-01-11
公開日2015-02-11
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.246 Å)
主引用文献Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
Nature, 520, 2015
3WST
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BU of 3wst by Molmil
Crystal structure of C.elegans PRMT7 in complex with SAH(P31)
分子名称: PHOSPHATE ION, Protein arginine N-methyltransferase 7, S-ADENOSYL-L-HOMOCYSTEINE
著者Hasegawa, M, Toma-fukai, S, Shimizu, T.
登録日2014-03-21
公開日2014-04-23
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献Protein arginine methyltransferase 7 has a novel homodimer-like structure formed by tandem repeats
Febs Lett., 588, 2014
3WPH
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BU of 3wph by Molmil
Crystal structure of mouse TLR9 in complex with inhibitory DNA4084 (form 2)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (5'-D(*CP*CP*TP*GP*GP*AP*TP*GP*GP*GP*AP*A)-3'), SULFATE ION, ...
著者Ohto, U, Shimizu, T.
登録日2014-01-11
公開日2015-02-11
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.327 Å)
主引用文献Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
Nature, 520, 2015
2COV
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BU of 2cov by Molmil
Crystal structure of CBM31 from beta-1,3-xylanase
分子名称: beta-1,3-xylanase
著者Hashimoto, H, Tamai, Y, Okazaki, F, Tamaru, Y, Shimizu, T, Araki, T, Sato, M.
登録日2005-05-18
公開日2005-09-13
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献The first crystal structure of a family 31 carbohydrate-binding module with affinity to beta-1,3-xylan
Febs Lett., 579, 2005
3W4J
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BU of 3w4j by Molmil
Crystal Structure of human DAAO in complex with coumpound 12
分子名称: 3-hydroxy-5-(2-phenylethyl)pyridin-2(1H)-one, D-amino-acid oxidase, FLAVIN-ADENINE DINUCLEOTIDE
著者Hondo, T, Warizaya, M, Niimi, T, Namatame, I, Yamaguchi, T, Nakanishi, K, Hamajima, T, Harada, K, Sakashita, H, Matsumoto, Y, Orita, M, Watanabe, T, Takeuchi, M.
登録日2013-01-09
公開日2013-05-29
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.74 Å)
主引用文献4-Hydroxypyridazin-3(2H)-one Derivatives as Novel d-Amino Acid Oxidase Inhibitors.
J.Med.Chem., 56, 2013
4QC0
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BU of 4qc0 by Molmil
Crystal structure of human TLR8 in complex with XG-1-236
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-butyl-2H-pyrazolo[3,4-c]quinolin-4-amine, Toll-like receptor 8, ...
著者Tanji, H, Ohto, U, Shimizu, T.
登録日2014-05-09
公開日2014-10-22
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Determinants of Activity at Human Toll-like Receptors 7 and 8: Quantitative Structure-Activity Relationship (QSAR) of Diverse Heterocyclic Scaffolds
J.Med.Chem., 57, 2014
3WN4
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BU of 3wn4 by Molmil
Crystal structure of human TLR8 in complex with DS-877
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-butylfuro[2,3-c]quinolin-4-amine, Toll-like receptor 8, ...
著者Tanji, H, Ohto, U, Shimizu, T.
登録日2013-12-02
公開日2014-02-19
最終更新日2022-08-24
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Structure-based design of novel human Toll-like receptor 8 agonists.
Chemmedchem, 9, 2014
3W4I
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BU of 3w4i by Molmil
Crystal Structure of human DAAO in complex with coumpound 8
分子名称: D-amino-acid oxidase, FLAVIN-ADENINE DINUCLEOTIDE, pyridine-2,3-diol
著者Hondo, T, Warizaya, M, Niimi, T, Namatame, I, Yamaguchi, T, Nakanishi, K, Hamajima, T, Harada, K, Sakashita, H, Matsumoto, Y, Orita, M, Watanabe, T, Takeuchi, M.
登録日2013-01-09
公開日2013-05-29
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献4-Hydroxypyridazin-3(2H)-one Derivatives as Novel d-Amino Acid Oxidase Inhibitors.
J.Med.Chem., 56, 2013
3W4K
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BU of 3w4k by Molmil
Crystal Structure of human DAAO in complex with coumpound 13
分子名称: 3-hydroxy-6-(2-phenylethyl)pyridazin-4(1H)-one, D-amino-acid oxidase, FLAVIN-ADENINE DINUCLEOTIDE
著者Hondo, T, Warizaya, M, Niimi, T, Namatame, I, Yamaguchi, T, Nakanishi, K, Hamajima, T, Harada, K, Sakashita, H, Matsumoto, Y, Orita, M, Watanabe, T, Takeuchi, M.
登録日2013-01-09
公開日2013-05-29
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.86 Å)
主引用文献4-Hydroxypyridazin-3(2H)-one Derivatives as Novel d-Amino Acid Oxidase Inhibitors.
J.Med.Chem., 56, 2013
2OFF
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BU of 2off by Molmil
The crystal structure of Glycogen Phosphorylase b in complex with a potent allosteric inhibitor
分子名称: 2-DEOXY-3,4-BIS-O-[3-(4-HYDROXYPHENYL)PROPANOYL]-L-THREO-PENTARIC ACID, Glycogen phosphorylase, muscle form
著者Tiraidis, C, Alexacou, K.-M, Zographos, S.E, Leonidas, D.D, Gimisis, T, Oikonomakos, N.G.
登録日2007-01-03
公開日2007-08-07
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献FR258900, a potential anti-hyperglycemic drug, binds at the allosteric site of glycogen phosphorylase
Protein Sci., 16, 2007
4G8A
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BU of 4g8a by Molmil
Crystal structure of human TLR4 polymorphic variant D299G and T399I in complex with MD-2 and LPS
分子名称: (R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Ohto, U, Shimizu, T.
登録日2012-07-23
公開日2012-10-17
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural analyses of human Toll-like receptor 4 polymorphisms D299G and T399I
J.Biol.Chem., 287, 2012
2A0B
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BU of 2a0b by Molmil
HISTIDINE-CONTAINING PHOSPHOTRANSFER DOMAIN OF ARCB FROM ESCHERICHIA COLI
分子名称: HPT DOMAIN, ZINC ION
著者Kato, M, Mizuno, T, Shimizu, T, Hakoshima, T.
登録日1998-04-02
公開日1998-06-17
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献Refined structure of the histidine-containing phosphotransfer (HPt) domain of the anaerobic sensor kinase ArcB from Escherichia coli at 1.57 A resolution.
Acta Crystallogr.,Sect.D, 55, 1999
3VIQ
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BU of 3viq by Molmil
Crystal structure of Swi5-Sfr1 complex from fission yeast
分子名称: GLYCEROL, Mating-type switching protein swi5, NITRATE ION, ...
著者Kuwabara, N, Murayama, Y, Hashimoto, H, Kokabu, Y, Ikeguchi, M, Sato, M, Mayanagi, K, Tsutsui, Y, Iwasaki, H, Shimizu, T.
登録日2011-10-06
公開日2012-08-22
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Mechanistic insights into the activation of Rad51-mediated strand exchange from the structure of a recombination activator, the Swi5-Sfr1 complex
Structure, 20, 2012
3VQ1
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BU of 3vq1 by Molmil
Crystal structure of mouse TLR4/MD-2/lipid IVa complex
分子名称: (R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Ohto, U, Shimizu, T.
登録日2012-03-17
公開日2012-05-09
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2
Proc.Natl.Acad.Sci.USA, 109, 2012
2ZFD
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BU of 2zfd by Molmil
The crystal structure of plant specific calcium binding protein AtCBL2 in complex with the regulatory domain of AtCIPK14
分子名称: ACETIC ACID, CALCIUM ION, Calcineurin B-like protein 2, ...
著者Akaboshi, M, Hashimoto, H, Ishida, H, Koizumi, N, Sato, M, Shimizu, T.
登録日2007-12-29
公開日2008-02-19
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献The crystal structure of plant-specific calcium-binding protein AtCBL2 in complex with the regulatory domain of AtCIPK14
J.Mol.Biol., 377, 2008
3VQ2
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BU of 3vq2 by Molmil
Crystal structure of mouse TLR4/MD-2/LPS complex
分子名称: (R)-((2R,3S,4R,5R,6R)-3-HYDROXY-2-(HYDROXYMETHYL)-5-((R)-3-HYDROXYTETRADECANAMIDO)-6-(PHOSPHONOOXY)TETRAHYDRO-2H-PYRAN-4-YL) 3-HYDROXYTETRADECANOATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Ohto, U, Shimizu, T.
登録日2012-03-17
公開日2012-05-09
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2
Proc.Natl.Acad.Sci.USA, 109, 2012
3VIR
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BU of 3vir by Molmil
Crystal strcture of Swi5 from fission yeast
分子名称: Mating-type switching protein swi5, octyl beta-D-glucopyranoside
著者Kuwabara, N, Yamada, N, Hashimoto, H, Sato, M, Iwasaki, H, Shimizu, T.
登録日2011-10-06
公開日2012-08-22
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Mechanistic insights into the activation of Rad51-mediated strand exchange from the structure of a recombination activator, the Swi5-Sfr1 complex
Structure, 20, 2012
2DEX
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BU of 2dex by Molmil
Crystal structure of human peptidylarginine deiminase 4 in complex with histone H3 N-terminal peptide including Arg17
分子名称: 10-mer peptide from histone H3, CALCIUM ION, Protein-arginine deiminase type IV, ...
著者Arita, K, Shimizu, T, Hashimoto, H, Hidaka, Y, Yamada, M, Sato, M.
登録日2006-02-18
公開日2006-04-11
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4
Proc.Natl.Acad.Sci.Usa, 103, 2006
2DEW
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BU of 2dew by Molmil
Crystal structure of human peptidylarginine deiminase 4 in complex with histone H3 N-terminal tail including Arg8
分子名称: 10-mer peptide from histone H3, CALCIUM ION, Protein-arginine deiminase type IV, ...
著者Arita, K, Shimizu, T, Hashimoto, H, Hidaka, Y, Yamada, M, Sato, M.
登録日2006-02-18
公開日2006-04-11
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4
Proc.Natl.Acad.Sci.Usa, 103, 2006
3VKX
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BU of 3vkx by Molmil
Structure of PCNA
分子名称: 3,5,3'TRIIODOTHYRONINE, CHLORIDE ION, Proliferating cell nuclear antigen, ...
著者Hashimoto, H, Hishiki, A, Shimizu, T, Sato, M, Punchihewa, C, Connelly, M, Actis, M, Waddell, B, Pagala, V, Fujii, N.
登録日2011-11-26
公開日2012-03-14
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication
J.Biol.Chem., 287, 2012
2DEY
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Crystal structure of human peptidylarginine deiminase 4 in complex with histone H4 N-terminal tail including Arg3
分子名称: 10-mer peptide from histone H4, CALCIUM ION, Protein-arginine deiminase type IV, ...
著者Arita, K, Shimizu, T, Hashimoto, H, Hidaka, Y, Yamada, M, Sato, M.
登録日2006-02-18
公開日2006-04-11
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4
Proc.Natl.Acad.Sci.Usa, 103, 2006

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