3VJH

Human PPAR GAMMA ligand binding domain in complex with JKPL35

Summary for 3VJH

• Entry DOI: 10.2210/pdb3vjh/pdb
• Related: 3VJI
• Descriptor: Peroxisome proliferator-activated receptor gamma, (2S)-2-[4-methoxy-3-({[4-(trifluoromethyl)benzoyl]amino}methyl)benzyl]pentanoic acid (3 entities in total)
• Functional Keywords: transcription
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P37231
• Total number of polymer chains: 2
• Total formula weight: 65484.73

Authors

Tomioka, D.,Kuwabara, N.,Hashimoto, H.,Sato, M.,Shimizu, T. (deposition date: 2011-10-20, release date: 2012-08-29, Last modification date: 2023-11-08)

• Primary citation: Kuwabara, N.,Oyama, T.,Tomioka, D.,Ohashi, M.,Yanagisawa, J.,Shimizu, T.,Miyachi, H.; Peroxisome proliferator-activated receptors (PPARs) have multiple binding points that accommodate ligands in various conformations: phenylpropanoic acid-type PPAR ligands bind to PPAR in different conformations, depending on the subtype.; J.Med.Chem., 55:893-902, 2012; PubMed: 22185225; DOI: 10.1021/jm2014293

Experimental method

X-RAY DIFFRACTION (2.22 Å)