3W4J

Crystal Structure of human DAAO in complex with coumpound 12

Summary for 3W4J

Entry DOI	10.2210/pdb3w4j/pdb
Related	3W4I 3W4K
Descriptor	D-amino-acid oxidase, FLAVIN-ADENINE DINUCLEOTIDE, 3-hydroxy-5-(2-phenylethyl)pyridin-2(1H)-one (3 entities in total)
Functional Keywords	oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Peroxisome: P14920
Total number of polymer chains	4
Total formula weight	162086.83
Authors	Hondo, T.,Warizaya, M.,Niimi, T.,Namatame, I.,Yamaguchi, T.,Nakanishi, K.,Hamajima, T.,Harada, K.,Sakashita, H.,Matsumoto, Y.,Orita, M.,Watanabe, T.,Takeuchi, M. (deposition date: 2013-01-09, release date: 2013-05-29, Last modification date: 2024-03-20)
Primary citation	Hondo, T.,Warizaya, M.,Niimi, T.,Namatame, I.,Yamaguchi, T.,Nakanishi, K.,Hamajima, T.,Harada, K.,Sakashita, H.,Matsumoto, Y.,Orita, M.,Takeuchi, M. 4-Hydroxypyridazin-3(2H)-one Derivatives as Novel d-Amino Acid Oxidase Inhibitors. J.Med.Chem., 56:3582-3592, 2013 Cited by PubMed: 23566269 DOI: 10.1021/jm400095b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.74 Å)

Structure validation