2DM6

Crystal structure of anti-configuration of indomethacin and leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase complex

Summary for 2DM6

Entry DOI	10.2210/pdb2dm6/pdb
Related	1V3T 1V3U 1V3V
Descriptor	NADP-dependent leukotriene B4 12-hydroxydehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, INDOMETHACIN, ... (5 entities in total)
Functional Keywords	nad(p)-binding rossmann-fold domains, riken structural genomics/proteomics initiative, rsgi, structural genomics, oxidoreductase
Biological source	Cavia porcellus (domestic guinea pig)
Cellular location	Cytoplasm : Q9EQZ5
Total number of polymer chains	2
Total formula weight	74471.76
Authors	Hori, T.,Ishijima, J.,Yokomizo, T.,Ago, H.,Shimizu, T.,Miyano, M.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2006-04-20, release date: 2006-11-28, Last modification date: 2017-10-11)
Primary citation	Hori, T.,Ishijima, J.,Yokomizo, T.,Ago, H.,Shimizu, T.,Miyano, M. Crystal structure of anti-configuration of indomethacin and leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase complex reveals the structural basis of broad spectrum indomethacin efficacy J.Biochem.(Tokyo), 140:457-466, 2006 Cited by PubMed: 16916844 DOI: 10.1093/jb/mvj176 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation