2DM6
Crystal structure of anti-configuration of indomethacin and leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | NADP-dependent leukotriene B4 12-hydroxydehydrogenase | polymer | 333 | 36232.0 | 2 | UniProt (Q9EQZ5) Pfam (PF16884) Pfam (PF00107) | Cavia porcellus (domestic guinea pig) | dehydrogenase/reductase, LTB4, 12-HD, 15-oxoprostaglandin 13-reductase, PGR |
| 2 | C, E (A, B) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 2 | Chemie (NAP) | |||
| 3 | D (A) | INDOMETHACIN | non-polymer | 357.8 | 1 | Chemie (IMN) | |||
| 4 | F (B) | TRIS(HYDROXYETHYL)AMINOMETHANE | non-polymer | 163.2 | 1 | Chemie (TAM) | |||
| 5 | G, H (A, B) | water | water | 18.0 | 600 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 329 (UniProt: Q9EQZ5)
| PDB | External Database | Details |
|---|---|---|
| Ser -4 | - | cloning artifact |
| Pro -3 | - | cloning artifact |
| Glu -2 | - | cloning artifact |
| Phe -1 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 72463.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2007.8 | |
| All* | Total formula weight | 74471.8 |
