2M3G
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![BU of 2m3g by Molmil](/molmil-images/mine/2m3g) | Structure of Anabaena Sensory Rhodopsin Determined by Solid State NMR Spectroscopy | Descriptor: | Anabaena Sensory Rhodopsin, RETINAL | Authors: | Wang, S, Munro, R.A, Shi, L, Kawamura, I, Okitsu, T, Wada, A, Kim, S, Jung, K, Brown, L.S, Ladizhansky, V. | Deposit date: | 2013-01-17 | Release date: | 2013-08-21 | Last modified: | 2023-06-14 | Method: | SOLID-STATE NMR | Cite: | Solid-state NMR spectroscopy structure determination of a lipid-embedded heptahelical membrane protein. Nat.Methods, 10, 2013
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3UDK
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![BU of 3udk by Molmil](/molmil-images/mine/3udk) | Crystal Structure of BACE with Compound 6 | Descriptor: | 1,2-ETHANEDIOL, Beta-secretase 1, DI(HYDROXYETHYL)ETHER, ... | Authors: | Efremov, I.V, Vajdos, F.F, Borzilleri, K, Capetta, S, Dorff, P, Dutra, J, Mansour, M, Oborski, C, O'Connell, T, O'Sullivan, T.J, Pandit, J, Wang, H, Withka, J. | Deposit date: | 2011-10-28 | Release date: | 2012-04-18 | Last modified: | 2018-04-04 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Discovery and optimization of a novel spiropyrrolidine inhibitor of {beta}-secretase (BACE1) through fragment-based drug design. J.Med.Chem., 55, 2012
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2UW0
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![BU of 2uw0 by Molmil](/molmil-images/mine/2uw0) | Structure of PKA-PKB chimera complexed with 6-(4-(4-(4-Chloro-phenyl) -piperidin-4-yl)-phenyl)-9H-purine | Descriptor: | 6-{4-[4-(4-CHLOROPHENYL)PIPERIDIN-4-YL]PHENYL}-9H-PURINE, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, CAMP-DEPENDENT PROTEIN KINASE, ... | Authors: | Davies, T.G, Donald, A, McHardy, T, Rowlands, M.G, Hunter, L.J, Boyle, R.G, Aherne, G.W, Garrett, M.D, Collins, I. | Deposit date: | 2007-03-15 | Release date: | 2007-05-08 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Rapid Evolution of 6-Phenylpurine Inhibitors of Protein Kinase B Through Structure-Based Design J.Med.Chem., 50, 2007
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2UY8
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![BU of 2uy8 by Molmil](/molmil-images/mine/2uy8) | R92A mutant of Bacillus subtilis Oxalate Decarboxylase OxdC | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MANGANESE (II) ION, OXALATE DECARBOXYLASE OXDC | Authors: | Just, V.J, Burrell, M.R, Bowater, L, McRobbie, I, Stevenson, C.E.M, Lawson, D.M, Bornemann, S. | Deposit date: | 2007-04-03 | Release date: | 2007-08-21 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The Identity of the Active Site of Oxalate Decarboxylase and the Importance of the Stability of Active-Site Lid Conformations. Biochem.J., 407, 2007
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2M87
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![BU of 2m87 by Molmil](/molmil-images/mine/2m87) | |
2LV1
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![BU of 2lv1 by Molmil](/molmil-images/mine/2lv1) | Solution-state NMR structure of prion protein mutant V210I at neutral pH | Descriptor: | Major prion protein | Authors: | Biljan, I, Ilc, G, Giachin, G, Legname, G, Plavec, J. | Deposit date: | 2012-06-26 | Release date: | 2012-09-19 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Structural Rearrangements at Physiological pH: Nuclear Magnetic Resonance Insights from the V210I Human Prion Protein Mutant. Biochemistry, 51, 2012
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2UVX
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![BU of 2uvx by Molmil](/molmil-images/mine/2uvx) | Structure of PKA-PKB chimera complexed with 7-azaindole | Descriptor: | 1H-PYRROLO[2,3-B]PYRIDINE, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, CAMP-DEPENDENT PROTEIN KINASE, ... | Authors: | Davies, T.G, Donald, A, McHardy, T, Rowlands, M.G, Hunter, L.J, Boyle, R.G, Aherne, G.W, Garrett, M.D, Collins, I. | Deposit date: | 2007-03-15 | Release date: | 2007-05-08 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Rapid Evolution of 6-Phenylpurine Inhibitors of Protein Kinase B Through Structure-Based Design J.Med.Chem., 50, 2007
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2LYC
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![BU of 2lyc by Molmil](/molmil-images/mine/2lyc) | Structure of C-terminal domain of Ska1 | Descriptor: | Spindle and kinetochore-associated protein 1 homolog | Authors: | Boeszoermenyi, A, Schmidt, J.C, Markus, M, Oberer, M, Cheeseman, I.M, Wagner, G, Arthanari, H. | Deposit date: | 2012-09-14 | Release date: | 2012-10-24 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The kinetochore-bound ska1 complex tracks depolymerizing microtubules and binds to curved protofilaments. Dev.Cell, 23, 2012
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2M09
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![BU of 2m09 by Molmil](/molmil-images/mine/2m09) | Structure, phosphorylation and U2AF65 binding of the Nterminal Domain of splicing factor 1 during 3 splice site Recognition | Descriptor: | Splicing factor 1 | Authors: | Madl, T, Sattler, M, Zhang, Y, Bagdiul, I, Kern, T, Kang, H, Zou, P, Maeusbacher, N, Sieber, S.A, Kraemer, A. | Deposit date: | 2012-10-22 | Release date: | 2013-01-30 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structure, phosphorylation and U2AF65 binding of the N-terminal domain of splicing factor 1 during 3'-splice site recognition. Nucleic Acids Res., 41, 2013
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2MDR
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![BU of 2mdr by Molmil](/molmil-images/mine/2mdr) | Solution structure of the third double-stranded RNA-binding domain (dsRBD3) of human adenosine-deaminase ADAR1 | Descriptor: | Double-stranded RNA-specific adenosine deaminase | Authors: | Barraud, P, Banerjee, S, Mohamed, W.I, Jantsch, M.F, Allain, F.H. | Deposit date: | 2013-09-17 | Release date: | 2014-04-30 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | A bimodular nuclear localization signal assembled via an extended double-stranded RNA-binding domain acts as an RNA-sensing signal for transportin 1. Proc.Natl.Acad.Sci.USA, 111, 2014
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5NZI
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![BU of 5nzi by Molmil](/molmil-images/mine/5nzi) | Crystal structure of UDP-glucose pyrophosphorylase S374F mutant from Leishmania major in complex with UDP-glucose | Descriptor: | 1,2-ETHANEDIOL, UDP-glucose pyrophosphorylase, URIDINE-5'-DIPHOSPHATE-GLUCOSE | Authors: | Cramer, J.T, Fuehring, J.I, Baruch, P, Bruetting, C, Hesse, R, Knoelker, H.-J, Gerardy-Schahn, R, Fedorov, R. | Deposit date: | 2017-05-14 | Release date: | 2018-04-18 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Decoding Allosteric Networks in Biocatalysts: Rational Approach to Therapies and Biotechnologies Acs Catalysis, 8, 2018
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2MEM
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![BU of 2mem by Molmil](/molmil-images/mine/2mem) | Solution NMR structure of SLED domain of Scml2 | Descriptor: | Sex comb on midleg-like protein 2 | Authors: | Bezsonova, I. | Deposit date: | 2013-09-24 | Release date: | 2014-04-23 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution NMR Structure of the DNA-binding Domain from Scml2 (Sex Comb on Midleg-like 2). J.Biol.Chem., 289, 2014
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2M5X
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![BU of 2m5x by Molmil](/molmil-images/mine/2m5x) | Novel method of protein purification for structural research. Example of ultra high resolution structure of SPI-2 inhibitor by X-ray and NMR spectroscopy. | Descriptor: | Silk protease inhibitor 2 | Authors: | Lenarcic Zivkovic, M, Dvornyk, A, Kludkiewicz, B, Kopera, E, Zagorski-Ostoja, W, Grzelak, K, Zhukov, I, Bal, W. | Deposit date: | 2013-03-12 | Release date: | 2014-03-12 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Atomic resolution structure of a protein prepared by non-enzymatic His-tag removal. Crystallographic and NMR study of GmSPI-2 inhibitor. Plos One, 9, 2014
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2MHH
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![BU of 2mhh by Molmil](/molmil-images/mine/2mhh) | Solution structure of a EF-hand domain from sea urchin polycystin-2 | Descriptor: | Polycystic kidney disease protein 2 | Authors: | Kuo, I.Y, Keeler, C, Corbin, R, Celic, A, Petri, E.T, Hodsdon, M.E, Ehrlich, B.E. | Deposit date: | 2013-11-22 | Release date: | 2014-10-08 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | The number and location of EF hand motifs dictates the calcium dependence of polycystin-2 function. Faseb J., 28, 2014
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1CDJ
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![BU of 1cdj by Molmil](/molmil-images/mine/1cdj) | STRUCTURE OF T-CELL SURFACE GLYCOPROTEIN CD4 | Descriptor: | T-CELL SURFACE GLYCOPROTEIN CD4 | Authors: | Wu, H, Myszka, D, Tendian, S.W, Brouillette, C.G, Sweet, R.W, Chaiken, I.M, Hendrickson, W.A. | Deposit date: | 1996-11-11 | Release date: | 1997-04-01 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Kinetic and structural analysis of mutant CD4 receptors that are defective in HIV gp120 binding. Proc.Natl.Acad.Sci.USA, 93, 1996
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2MCE
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![BU of 2mce by Molmil](/molmil-images/mine/2mce) | |
5OA7
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![BU of 5oa7 by Molmil](/molmil-images/mine/5oa7) | Fe(II)/(alpha)ketoglutarate-dependent dioxygenase AsqJ_V72I mutant in complex with cyclopeptin (1b) | Descriptor: | 2-OXOGLUTARIC ACID, Iron/alpha-ketoglutarate-dependent dioxygenase asqJ, NICKEL (II) ION, ... | Authors: | Groll, M, Braeuer, A, Kaila, V.R.I. | Deposit date: | 2017-06-21 | Release date: | 2018-04-04 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Catalytic mechanism and molecular engineering of quinolone biosynthesis in dioxygenase AsqJ. Nat Commun, 9, 2018
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2LXM
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![BU of 2lxm by Molmil](/molmil-images/mine/2lxm) | Lip5-chmp5 | Descriptor: | Charged multivesicular body protein 5, Vacuolar protein sorting-associated protein VTA1 homolog | Authors: | Skalicky, J.J, Sundquist, W.I. | Deposit date: | 2012-08-29 | Release date: | 2012-11-28 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Interactions of the Human LIP5 Regulatory Protein with Endosomal Sorting Complexes Required for Transport. J.Biol.Chem., 287, 2012
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2UY9
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![BU of 2uy9 by Molmil](/molmil-images/mine/2uy9) | E162A mutant of Bacillus subtilis Oxalate Decarboxylase OxdC | Descriptor: | MANGANESE (II) ION, OXALATE DECARBOXYLASE OXDC | Authors: | Just, V.J, Burrell, M.R, Bowater, L, McRobbie, I, Stevenson, C.E.M, Lawson, D.M, Bornemann, S. | Deposit date: | 2007-04-03 | Release date: | 2007-08-21 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | The Identity of the Active Site of Oxalate Decarboxylase and the Importance of the Stability of Active-Site Lid Conformations. Biochem.J., 407, 2007
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2UYX
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![BU of 2uyx by Molmil](/molmil-images/mine/2uyx) | metallo-beta-lactamase (1BC2) single point mutant D120S | Descriptor: | BETA-LACTAMASE II, GLYCEROL, ZINC ION | Authors: | Larrull, L.I, Fabiane, S.M, Kowalski, J.M, Bennett, B, Sutton, B.J, Vila, A.J. | Deposit date: | 2007-04-20 | Release date: | 2007-05-08 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Asp-120 locates Zn2 for optimal metallo-beta-lactamase activity. J. Biol. Chem., 282, 2007
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2M4N
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![BU of 2m4n by Molmil](/molmil-images/mine/2m4n) | Solution structure of the putative Ras interaction domain of AFD-1, isoform a from Caenorhabditis elegans | Descriptor: | Protein AFD-1, isoform a | Authors: | Harris, R, Hillerich, B, Ahmed, M, Bonanno, J.B, Chamala, S, Evans, B, Lafleur, J, Hammonds, J, Washington, E, Stead, M, Love, J, Attonito, J, Seidel, R.D, Liddington, R.C, Weis, W.I, Nelson, W.J, Girvin, M.E, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Assembly, Dynamics and Evolution of Cell-Cell and Cell-Matrix Adhesions (CELLMAT) | Deposit date: | 2013-02-07 | Release date: | 2013-03-20 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution structure of the putative Ras interaction domain of AFD-1, isoform a from Caenorhabditis elegans To be Published
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5M7R
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![BU of 5m7r by Molmil](/molmil-images/mine/5m7r) | Structure of human O-GlcNAc hydrolase | Descriptor: | Protein O-GlcNAcase | Authors: | Roth, C, Chan, S, Offen, W.A, Hemsworth, G.R, Willems, L.I, King, D, Varghese, V, Britton, R, Vocadlo, D.J, Davies, G.J. | Deposit date: | 2016-10-28 | Release date: | 2017-03-29 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural and functional insight into human O-GlcNAcase. Nat. Chem. Biol., 13, 2017
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2M0R
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![BU of 2m0r by Molmil](/molmil-images/mine/2m0r) | Solution structure and dynamics of human S100A14 | Descriptor: | Protein S100-A14 | Authors: | Bertini, I, Borsi, V, Cerofolini, L, Das Gupta, S, Fragai, M, Luchinat, C. | Deposit date: | 2012-11-05 | Release date: | 2013-01-23 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution structure and dynamics of human S100A14. J.Biol.Inorg.Chem., 18, 2013
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5MBD
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![BU of 5mbd by Molmil](/molmil-images/mine/5mbd) | Structure of a bacterial light-regulated adenylyl cylcase | Descriptor: | Beta subunit of photoactivated adenylyl cyclase, CHLORIDE ION, FLAVIN MONONUCLEOTIDE | Authors: | Lindner, R, Hartmann, E, Tarnawski, M, Winkler, A, Frey, D, Reinstein, J, Meinhart, A, Schlichting, I. | Deposit date: | 2016-11-08 | Release date: | 2017-04-05 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Photoactivation Mechanism of a Bacterial Light-Regulated Adenylyl Cyclase. J. Mol. Biol., 429, 2017
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3VJE
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![BU of 3vje by Molmil](/molmil-images/mine/3vje) | Crystal structure of the Y248A mutant of C(30) carotenoid dehydrosqualene synthase from Staphylococcus aureus in complex with zaragozic acid A | Descriptor: | Dehydrosqualene synthase, Zaragozic acid A | Authors: | Liu, C.I, Jeng, W.Y, Chang, W.J, Wang, A.H.J. | Deposit date: | 2011-10-14 | Release date: | 2012-04-11 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | Binding modes of zaragozic acid A to human squalene synthase and staphylococcal dehydrosqualene synthase J.Biol.Chem., 287, 2012
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