2W05
| Structure of CDK2 in complex with an imidazolyl pyrimidine, compound 5b | 分子名称: | CELL DIVISION PROTEIN KINASE 2, N-(2-METHOXYETHYL)-4-({4-[2-METHYL-1-(1-METHYLETHYL)-1H-IMIDAZOL-5-YL]PYRIMIDIN-2-YL}AMINO)BENZENESULFONAMIDE | 著者 | Anderson, M, Andrews, D.M, Barker, A.J, Brassington, C.A, Breed, J, Byth, K.F, Culshaw, J.D, Finlay, M.R, Fisher, E, Green, C.P, Heaton, D.W, Nash, I.A, Newcombe, N.J, Oakes, S.E, Pauptit, R.A, Roberts, A, Stanway, J.J, Thomas, A.P, Tucker, J.A, Weir, H.M. | 登録日 | 2008-08-08 | 公開日 | 2008-10-14 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Imidazoles: Sar and Development of a Potent Class of Cyclin-Dependent Kinase Inhibitors. Bioorg.Med.Chem.Lett., 18, 2008
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1NVN
| Structural Characterisation of the Holliday junction formed by the sequence CCGGTACCGG at 1.8 A | 分子名称: | 5'-D(CpCpGpGpTpApCpCpGpG)-3', CALCIUM ION | 著者 | Cardin, C.J, Gale, B.C, Thorpe, J.H, Teixeira, S.C.M, Gan, Y, Moraes, M.I.A.A, Brogden, A.L. | 登録日 | 2003-02-04 | 公開日 | 2003-02-25 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural analysis of two Holliday junctions formed by the sequences TCGGTACCGA and CCGGTACCGG To be Published
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1NW5
| Structure of the beta class N6-adenine DNA methyltransferase RsrI bound to S-ADENOSYLMETHIONINE | 分子名称: | CHLORIDE ION, MODIFICATION METHYLASE RSRI, S-ADENOSYLMETHIONINE | 著者 | Thomas, C.B, Scavetta, R.D, Gumport, R.I, Churchill, M.E.A. | 登録日 | 2003-02-05 | 公開日 | 2003-07-29 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structures of liganded and unliganded RsrI N6-adenine DNA methyltransferase: a distinct orientation for active cofactor binding J.Biol.Chem., 278, 2003
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4MR6
| Crystal Structure of the second bromodomain of human BRD2 in complex with a quinazolinone ligand (RVX-208) | 分子名称: | 1,2-ETHANEDIOL, 2-[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]-5,7-dimethoxyquinazolin-4(3H)-one, Bromodomain-containing protein 2, ... | 著者 | Filippakopoulos, P, Picaud, S, Felletar, I, Martin, S, Fedorov, O, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2013-09-17 | 公開日 | 2013-11-27 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain. Proc.Natl.Acad.Sci.USA, 110, 2013
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2AEM
| Crystal Structures of the MthK RCK Domain | 分子名称: | Calcium-gated potassium channel mthK | 著者 | Dong, J, Shi, N, Berke, I, Chen, L, Jiang, Y. | 登録日 | 2005-07-22 | 公開日 | 2005-10-25 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structures of the MthK RCK Domain and the Effect of Ca2+ on Gating Ring Stability J.Biol.Chem., 280, 2005
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2ADV
| Crystal Structures Of Glutaryl 7-Aminocephalosporanic Acid Acylase: mutational study of activation mechanism | 分子名称: | Glutaryl 7- Aminocephalosporanic Acid Acylase | 著者 | Kim, J.K, Yang, I.S, Shin, H.J, Cho, K.J, Ryu, E.K, Kim, S.H, Park, S.S, Kim, K.H. | 登録日 | 2005-07-21 | 公開日 | 2006-01-24 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.244 Å) | 主引用文献 | Insight into autoproteolytic activation from the structure of cephalosporin acylase: a protein with two proteolytic chemistries. Proc.Natl.Acad.Sci.USA, 103, 2006
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3O6Q
| The Structure of SpoIISA and SpoIISB, a Toxin - Antitoxin System | 分子名称: | Stage II sporulation protein SA, Stage II sporulation protein SB | 著者 | Levdikov, V.M, Blagova, E.V, Lebedev, A.A, Wilkinson, A.J, Florek, P, Barak, I. | 登録日 | 2010-07-29 | 公開日 | 2010-12-08 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The structure and interactions of SpoIISA and SpoIISB, a toxin-antitoxin system in Bacillus subtilis. J.Biol.Chem., 161, 2010
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4MV5
| IspH in complex with 6-chloropyridin-3-ylmethyl diphosphate | 分子名称: | (6-chloropyridin-3-yl)methyl trihydrogen diphosphate, 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, FE3-S4 CLUSTER | 著者 | Span, I, Wang, K, Song, Y, Eisenreich, W, Bacher, A, Oldfield, E, Groll, M. | 登録日 | 2013-09-23 | 公開日 | 2014-06-18 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Insights into the Binding of Pyridines to the Iron-Sulfur Enzyme IspH. J.Am.Chem.Soc., 136, 2014
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1ZX6
| High-resolution crystal structure of yeast Pin3 SH3 domain | 分子名称: | Ypr154wp | 著者 | Kursula, P, Kursula, I, Lehmann, F, Zou, P, Song, Y.H, Wilmanns, M. | 登録日 | 2005-06-07 | 公開日 | 2006-10-24 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structural genomics of yeast SH3 domains To be Published
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4QSX
| Structure of the bromodomain of human ATPase family AAA domain-containing protein 2 (ATAD2) in complex with 3'-deoxy thymidine | 分子名称: | 1,2-ETHANEDIOL, 1-[(2R,5S)-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione, ATPase family AAA domain-containing protein 2, ... | 著者 | Chaikuad, A, Felletar, I, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2014-07-06 | 公開日 | 2014-07-23 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Structure-based approaches towards identification of fragments for the low-druggability ATAD2 bromodomain MedChemComm, 5, 2014
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4MXF
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1XLN
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1H2S
| Molecular basis of transmenbrane signalling by sensory rhodopsin II-transducer complex | 分子名称: | RETINAL, SENSORY RHODOPSIN II, SENSORY RHODOPSIN II TRANSDUCER, ... | 著者 | Gordeliy, V.I, Labahn, J, Moukhametzianov, R, Efremov, R, Granzin, J, Schlesinger, R, Bueldt, G, Savopol, T, Scheidig, A, Klare, J.P, Engelhard, M. | 登録日 | 2002-08-15 | 公開日 | 2002-10-10 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Molecular Basis of Transmembrane Signalling by Sensory Rhodopsin II-Transducer Complex Nature, 419, 2002
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1GSJ
| Selenomethionine substituted N-acetyl-L-glutamate kinase from Escherichia coli complexed with its substrate n-acetyl-L-glutamate and its substrate analog AMPPNP | 分子名称: | ACETYLGLUTAMATE KINASE, MAGNESIUM ION, N-ACETYL-L-GLUTAMATE, ... | 著者 | Ramon-Maiques, S, Marina, A, Gil-Ortiz, F, Fita, I, Rubio, V. | 登録日 | 2002-01-07 | 公開日 | 2002-05-16 | 最終更新日 | 2019-07-24 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structure of Acetylglutamate Kinase, a Key Enzyme for Arginine Biosynthesis and a Prototype for the Amino Acid Kinase Enzyme Family, During Catalysis Structure, 10, 2002
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4QTF
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2VVY
| Structure of Vaccinia virus protein B14 | 分子名称: | PROTEIN B15 | 著者 | Graham, S.C, Bahar, M.W, Cooray, S, Chen, R.A.-J, Whalen, D.M, Abrescia, N.G.A, Alderton, D, Owens, R.J, Stuart, D.I, Smith, G.L, Grimes, J.M. | 登録日 | 2008-06-12 | 公開日 | 2008-08-26 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.693 Å) | 主引用文献 | Vaccinia Virus Proteins A52 and B14 Share a Bcl-2-Like Fold But Have Evolved to Inhibit NF-kappaB Rather Than Apoptosis Plos Pathog., 4, 2008
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1X82
| CRYSTAL STRUCTURE OF PHOSPHOGLUCOSE ISOMERASE FROM PYROCOCCUS FURIOSUS WITH BOUND 5-phospho-D-arabinonate | 分子名称: | 5-PHOSPHOARABINONIC ACID, Glucose-6-phosphate isomerase | 著者 | Berrisford, J.M, Akerboom, J, Brouns, S, Sedelnikova, S.E, Turnbull, A.P, van der Oost, J, Salmon, L, Hardre, R, Murray, I.A, Blackburn, G.M, Rice, D.W, Baker, P.J. | 登録日 | 2004-08-17 | 公開日 | 2004-10-12 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | The structures of inhibitor complexes of Pyrococcus furiosus phosphoglucose isomerase provide insights into substrate binding and catalysis. J.Mol.Biol., 343, 2004
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4QVR
| 2.3 Angstrom Crystal Structure of Hypothetical Protein FTT1539c from Francisella tularensis. | 分子名称: | Uncharacterized hypothetical protein FTT_1539c | 著者 | Minasov, G, Shuvalova, L, Dubrovska, I, Flores, K, Ren, G, Huntley, J.F, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2014-07-15 | 公開日 | 2014-07-30 | 最終更新日 | 2018-01-24 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | 2.3 Angstrom Crystal Structure of Hypothetical Protein FTT1539c from Francisella tularensis. TO BE PUBLISHED
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4QX1
| Cry3A Toxin structure obtained by Serial Femtosecond Crystallography from in vivo grown crystals isolated from Bacillus thuringiensis and data processed with the CrystFEL software suite | 分子名称: | Pesticidal crystal protein cry3Aa | 著者 | Sawaya, M.R, Cascio, D, Gingery, M, Rodriguez, J, Goldschmidt, L, Colletier, J.-P, Messerschmidt, M, Boutet, S, Koglin, J.E, Williams, G.J, Brewster, A.S, Nass, K, Hattne, J, Botha, S, Doak, R.B, Shoeman, R.L, DePonte, D.P, Park, H.-W, Federici, B.A, Sauter, N.K, Schlichting, I, Eisenberg, D. | 登録日 | 2014-07-17 | 公開日 | 2014-08-13 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Protein crystal structure obtained at 2.9 angstrom resolution from injecting bacterial cells into an X-ray free-electron laser beam. Proc.Natl.Acad.Sci.USA, 111, 2014
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2W6O
| Crystal structure of Biotin carboxylase from E. coli in complex with 4-Amino-7,7-dimethyl-7,8-dihydro-quinazolinone fragment | 分子名称: | 4-amino-7,7-dimethyl-7,8-dihydroquinazolin-5(6H)-one, BIOTIN CARBOXYLASE, CHLORIDE ION | 著者 | Mochalkin, I, Miller, J.R. | 登録日 | 2008-12-18 | 公開日 | 2009-05-19 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches. Acs Chem.Biol., 4, 2009
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2VNN
| Human BACE-1 in complex with 7-ethyl-N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((3-(trifluoromethyl)phenyl)methyl)amino)propyl)-1- methyl-3,4-dihydro-1H-(1,2,5)thiadiazepino(3,4,5-hi)indole-9- carboxamide 2,2-dioxide | 分子名称: | BETA-SECRETASE 1, N-[(1S,2R)-1-benzyl-2-hydroxy-3-{[3-(trifluoromethyl)benzyl]amino}propyl]-7-ethyl-1-methyl-3,4-dihydro-1H-[1,2,5]thiadiazepino[3,4,5-hi]indole-9-carboxamide 2,2-dioxide | 著者 | Charrier, N, Clarke, B, Cutler, L, Demont, E, Dingwall, C, Dunsdon, R, East, P, Hawkins, J, Howes, C, Hussain, I, Jeffrey, P, Maile, G, Matico, R, Mosley, J, Naylor, A, OBrien, A, Redshaw, S, Rowland, P, Soleil, V, Smith, K.J, Sweitzer, S, Theobald, P, Vesey, D, Walter, D.S, Wayne, G. | 登録日 | 2008-02-05 | 公開日 | 2008-05-20 | 最終更新日 | 2019-05-15 | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | 主引用文献 | Second Generation of Hydroxyethylamine Bace-1 Inhibitors: Optimizing Potency and Oral Bioavailability. J.Med.Chem., 51, 2008
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4GZT
| N2 neuraminidase D151G mutant of A/Tanzania/205/2010 H3N2 in complex with oseltamivir carboxylate | 分子名称: | (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhu, X, Wilson, I.A. | 登録日 | 2012-09-06 | 公開日 | 2012-10-17 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Influenza virus neuraminidases with reduced enzymatic activity that avidly bind sialic Acid receptors. J.Virol., 86, 2012
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1Q6Q
| Structure of 3-keto-L-gulonate 6-phosphate decarboxylase with bound xylitol 5-phosphate | 分子名称: | 3-keto-L-gulonate 6-phosphate decarboxylase, L-XYLITOL 5-PHOSPHATE, MAGNESIUM ION | 著者 | Wise, E.L, Yew, W.S, Gerlt, J.A, Rayment, I. | 登録日 | 2003-08-13 | 公開日 | 2003-10-28 | 最終更新日 | 2019-07-24 | 実験手法 | X-RAY DIFFRACTION (1.695 Å) | 主引用文献 | Structural Evidence for a 1,2-Enediolate Intermediate in the Reaction Catalyzed by 3-Keto-l-Gulonate 6-Phosphate Decarboxylase, a Member of the Orotidine 5'-Monophosphate Decarboxylase Suprafamily Biochemistry, 42, 2003
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1H2L
| Factor Inhibiting HIF-1 alpha in complex with HIF-1 alpha fragment peptide | 分子名称: | 2-OXOGLUTARIC ACID, FACTOR INHIBITING HIF1, FE (II) ION, ... | 著者 | Elkins, J.M, Hewitson, K.S, McNeill, L.A, Schlemminger, I, Seibel, J.F, Schofield, C.J. | 登録日 | 2002-08-12 | 公開日 | 2002-11-28 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Structure of Factor-Inhibiting Hypoxia-Inducible Factor (Hif) Reveals Mechanism of Oxidative Modification of Hif-1Alpha J.Biol.Chem., 278, 2003
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1H9E
| LEM-LIKE DOMAIN OF HUMAN INNER NUCLEAR MEMBRANE PROTEIN LAP2 | 分子名称: | LAMINA-ASSOCIATED POLYPEPTIDE 2 | 著者 | Laguri, C, Gilquin, B, Wolff, N, Romi-Lebrun, R, Courchay, K, Callebaut, I, Worman, H.J, Zinn-Justin, S. | 登録日 | 2001-03-08 | 公開日 | 2001-06-17 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural Characterization of the Lem Motif Common to Three Human Inner Nuclear Membrane Proteins Structure, 9, 2001
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