4MXF
X-ray structure of the adduct between bovine pancreatic ribonuclease and Auoxo6, a dinuclear gold(III) complex with -dioxo bridges linking the two metal centers
Summary for 4MXF
| Entry DOI | 10.2210/pdb4mxf/pdb |
| Related | 1JVT 1JVU 1JVV 4L55 4LFX |
| Descriptor | Ribonuclease pancreatic, GOLD ION (3 entities in total) |
| Functional Keywords | ribonuclease fold, hydrolase, rna |
| Biological source | Bos taurus (bovine,cow,domestic cattle,domestic cow) |
| Cellular location | Secreted: P61823 |
| Total number of polymer chains | 2 |
| Total formula weight | 27613.62 |
| Authors | Russo Krauss, I.,Vergara, A.,Merlino, A. (deposition date: 2013-09-26, release date: 2013-12-25, Last modification date: 2024-11-06) |
| Primary citation | Messori, L.,Scaletti, F.,Massai, L.,Cinellu, M.A.,Russo Krauss, I.,di Martino, G.,Vergara, A.,Paduano, L.,Merlino, A. Interactions of gold-based drugs with proteins: crystal structure of the adduct formed between ribonuclease A and a cytotoxic gold(iii) compound. Metallomics, 6:233-236, 2014 Cited by PubMed Abstract: The reaction of Auoxo6, a dinuclear gold(III) complex, with the model protein bovine pancreatic ribonuclease is explored here by X-ray diffraction and ESI mass spectrometry. Data provide clues on the processes of adduct formation and of enzyme inhibition and, inductively, on the likely mode of action of this metallodrug. PubMed: 24287583DOI: 10.1039/c3mt00265a PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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