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PDB: 13 件
6IJI
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BU of 6iji by Molmil
Crystal structure of PDE10 in complex with inhibitor 2b
分子名称: 2-{2-[5-methyl-1-(pyridin-4-yl)-1H-benzimidazol-2-yl]ethyl}-1H-benzo[de]isoquinoline-1,3(2H)-dione, MAGNESIUM ION, ZINC ION, ...
著者Huang, Y.Y, Yu, Y.F, Zhang, C, Wu, D, Wu, Y, Luo, H.B.
登録日2018-10-10
公開日2019-04-10
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Validation of Phosphodiesterase-10 as a Novel Target for Pulmonary Arterial Hypertension via Highly Selective and Subnanomolar Inhibitors.
J. Med. Chem., 62, 2019
6IJH
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BU of 6ijh by Molmil
Crystal structure of PDE10 in complex with inhibitor AF-399/14387019
分子名称: 2-[2-(4-phenyl-5-sulfanylidene-4,5-dihydro-1H-1,2,4-triazol-3-yl)ethyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione, MAGNESIUM ION, ZINC ION, ...
著者Huang, Y.Y, Yu, Y.F, Zhang, C, Wu, D, Wu, Y, Luo, H.B.
登録日2018-10-10
公開日2019-04-10
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Validation of Phosphodiesterase-10 as a Novel Target for Pulmonary Arterial Hypertension via Highly Selective and Subnanomolar Inhibitors.
J. Med. Chem., 62, 2019
6LZZ
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BU of 6lzz by Molmil
Crystal structure of the PDE9 catalytic domain in complex with inhibitor 4a
分子名称: 1-cyclopentyl-6-[[(2R)-1-(2-oxa-6-azaspiro[3.3]heptan-6-yl)-1-oxidanylidene-propan-2-yl]amino]-5H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ...
著者Huang, Y.Y, Wu, Y, Luo, H.B.
登録日2020-02-19
公開日2021-02-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.40003753 Å)
主引用文献Identification of phosphodiesterase-9 as a novel target for pulmonary arterial hypertension by using highly selective and orally bioavailable inhibitors
To Be Published
8WKF
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BU of 8wkf by Molmil
Rational Design of Highly Selective PDE5 inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis
分子名称: 3-[2-[[5-chloranyl-2-[(3-fluorophenyl)methylamino]phenyl]methyl]-4-oxidanylidene-3~{H}-quinazolin-7-yl]prop-2-enoic acid, MAGNESIUM ION, ZINC ION, ...
著者Zhang, F.C, Huang, Y.Y.
登録日2023-09-27
公開日2024-10-02
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Rational Design of Highly Selective PDE5 inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis
To Be Published
8WKG
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BU of 8wkg by Molmil
Rational Design of Highly Selective PDE5 inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis
分子名称: (~{E})-3-[2-[(3-chlorophenyl)methyl]-4-oxidanylidene-3~{H}-quinazolin-7-yl]prop-2-enoic acid, MAGNESIUM ION, ZINC ION, ...
著者Zhang, F.C, Huang, Y.Y.
登録日2023-09-27
公開日2024-10-02
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Rational Design of Highly Selective PDE5 inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis
To Be Published
5ZZ2
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BU of 5zz2 by Molmil
Crystal structure of PDE5 in complex with inhibitor LW1634
分子名称: 3-[(2H-1,3-benzodioxol-5-yl)methyl]-8-fluoro-1-(1,3-thiazol-2-yl)[1]benzopyrano[2,3-c]pyrrol-9(2H)-one, MAGNESIUM ION, SULFATE ION, ...
著者Wu, D, Huang, Y.D, Huang, Y.Y, Luo, H.B.
登録日2018-05-29
公開日2018-09-19
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Optimization of Chromeno[2,3- c]pyrrol-9(2 H)-ones as Highly Potent, Selective, and Orally Bioavailable PDE5 Inhibitors: Structure-Activity Relationship, X-ray Crystal Structure, and Pharmacodynamic Effect on Pulmonary Arterial Hypertension.
J. Med. Chem., 61, 2018
6ACB
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BU of 6acb by Molmil
Crystal structure of PDE5 in complex with inhibitor LW1805
分子名称: 3-[(2H-1,3-benzodioxol-5-yl)methyl]-8-fluoro-6-{[2-(4-methylpiperazin-1-yl)ethyl]amino}-1-(1,3-thiazol-2-yl)[1]benzopyrano[2,3-c]pyrrol-9(2H)-one, MAGNESIUM ION, SULFATE ION, ...
著者Wu, D, Huang, Y.D, Huang, Y.Y, Luo, H.B.
登録日2018-07-26
公開日2018-09-19
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Optimization of Chromeno[2,3- c]pyrrol-9(2 H)-ones as Highly Potent, Selective, and Orally Bioavailable PDE5 Inhibitors: Structure-Activity Relationship, X-ray Crystal Structure, and Pharmacodynamic Effect on Pulmonary Arterial Hypertension.
J. Med. Chem., 61, 2018
7EIZ
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BU of 7eiz by Molmil
Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading
分子名称: Helicase, MAGNESIUM ION, Non-structural protein 10, ...
著者Yan, L, Yang, Y.X, Li, M.Y, Zhang, Y, Zheng, L.T, Ge, J, Huang, Y.C, Liu, Z.Y, Wang, T, Gao, S, Zhang, R, Huang, Y.Y, Guddat, L.W, Gao, Y, Rao, Z.H, Lou, Z.Y.
登録日2021-04-01
公開日2021-09-22
最終更新日2023-07-26
実験手法ELECTRON MICROSCOPY
主引用文献Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading
Cell, 184, 2021
7EGQ
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BU of 7egq by Molmil
Co-transcriptional capping machineries in SARS-CoV-2 RTC: Coupling of N7-methyltransferase and 3'-5' exoribonuclease with polymerase reveals mechanisms for capping and proofreading
分子名称: Helicase, MAGNESIUM ION, Non-structural protein 10, ...
著者Yan, L.M, Yang, Y.X, Li, M.Y, Zhang, Y, Zheng, L.T, Ge, J, Huang, Y.C, Liu, Z.Y, Wang, T, Gao, S, Zhang, R, Huang, Y.Y, Guddat, L.W, Gao, Y, Rao, Z.H, Lou, Z.Y.
登録日2021-03-25
公開日2021-07-21
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.35 Å)
主引用文献Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading.
Cell, 184, 2021
7FAR
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BU of 7far by Molmil
Crystal structure of PDE5A in complex with inhibitor L12
分子名称: 5-[bis(fluoranyl)methoxy]-2-[(4-chlorophenyl)methyl]-10-(3-methoxypropyl)-3,10-diazatricyclo[6.4.1.0^{4,13}]trideca-1,4(13),5,7-tetraen-9-one, MAGNESIUM ION, ZINC ION, ...
著者Wu, D, Huang, Y.Y, Luo, H.B.
登録日2021-07-07
公開日2022-05-18
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.40006471 Å)
主引用文献Free energy perturbation (FEP)-guided scaffold hopping.
Acta Pharm Sin B, 12, 2022
7FAQ
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BU of 7faq by Molmil
Crystal structure of PDE5A in complex with inhibitor L1
分子名称: 2-[(4-chlorophenyl)methyl]-5-methoxy-3,10-diazatricyclo[6.4.1.0^{4,13}]trideca-1,4(13),5,7-tetraen-9-one, MAGNESIUM ION, SULFATE ION, ...
著者Wu, D, Huang, Y.Y, Luo, H.B.
登録日2021-07-07
公開日2022-05-18
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.200136 Å)
主引用文献Free energy perturbation (FEP)-guided scaffold hopping.
Acta Pharm Sin B, 12, 2022
7WOI
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BU of 7woi by Molmil
Structure of the shaft pilin Spa2 from Corynebacterium glutamicum
分子名称: 1,2-ETHANEDIOL, GLYCEROL, Spa2
著者Wu, Y.F, Wang, L.T, Huang, Y.Y, Zhong, C, Zhou, J.
登録日2022-01-21
公開日2023-01-25
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.73 Å)
主引用文献Accelerating the design of pili-enabled living materials using an integrative technological workflow.
Nat.Chem.Biol., 2023
7F0I
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BU of 7f0i by Molmil
phosphodiesterase-9A in complex with inhibitor 4b
分子名称: 1-cyclopentyl-6-[[(2R)-1-(6-fluoranyl-2-azaspiro[3.3]heptan-2-yl)-1-oxidanylidene-propan-2-yl]amino]-5H-pyrazolo[3,4-d]pyrimidin-4-one, Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ...
著者Wu, Y, Huang, Y.Y, Luo, H.B.
登録日2021-06-04
公開日2022-04-13
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.70000887 Å)
主引用文献Discovery of Potent Phosphodiesterase-9 Inhibitors for the Treatment of Hepatic Fibrosis
J.Med.Chem., 64, 2021

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件を2024-10-02に公開中

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