8WKG

Rational Design of Highly Selective PDE5 inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis

Summary for 8WKG

• Entry DOI: 10.2210/pdb8wkg/pdb
• Descriptor: cGMP-specific 3',5'-cyclic phosphodiesterase, (~{E})-3-[2-[(3-chlorophenyl)methyl]-4-oxidanylidene-3~{H}-quinazolin-7-yl]prop-2-enoic acid, ZINC ION, ... (5 entities in total)
• Functional Keywords: hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 38908.70

Authors

Zhang, F.C.,Huang, Y.Y. (deposition date: 2023-09-27, release date: 2024-10-02)

• Primary citation: Zhang, F.C.,Huang, Y.Y.,Luo, H.B.,Wu, Y.N.; Rational Design of Highly Selective PDE5 inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.4 Å)