Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6IJH

Crystal structure of PDE10 in complex with inhibitor AF-399/14387019

Summary for 6IJH
Entry DOI10.2210/pdb6ijh/pdb
DescriptorcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
Functional Keywordshydrolase-inhibitor complex, hydrolase/inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight79904.94
Authors
Huang, Y.Y.,Yu, Y.F.,Zhang, C.,Wu, D.,Wu, Y.,Luo, H.B. (deposition date: 2018-10-10, release date: 2019-04-10, Last modification date: 2023-11-22)
Primary citationHuang, Y.Y.,Yu, Y.F.,Zhang, C.,Chen, Y.,Zhou, Q.,Li, Z.,Zhou, S.,Li, Z.,Guo, L.,Wu, D.,Wu, Y.,Luo, H.B.
Validation of Phosphodiesterase-10 as a Novel Target for Pulmonary Arterial Hypertension via Highly Selective and Subnanomolar Inhibitors.
J. Med. Chem., 62:3707-3721, 2019
Cited by
PubMed: 30888810
DOI: 10.1021/acs.jmedchem.9b00224
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon