6IJH
Crystal structure of PDE10 in complex with inhibitor AF-399/14387019
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | polymer | 343 | 39462.3 | 2 | UniProt (Q9Y233) | Homo sapiens (Human) | |
| 2 | C, F (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, G (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | E, H (A, B) | 2-[2-(4-phenyl-5-sulfanylidene-4,5-dihydro-1H-1,2,4-triazol-3-yl)ethyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione | non-polymer | 400.5 | 2 | Chemie (AEO) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 63 | Chemie (HOH) |
Sequence modifications
A, B: 449 - 789 (UniProt: Q9Y233)
| PDB | External Database | Details |
|---|---|---|
| His 447 | - | expression tag |
| Met 448 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 78924.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 980.3 | |
| All* | Total formula weight | 79904.9 |
