4HBM
| Ordering of the N Terminus of Human MDM2 by Small Molecule Inhibitors | 分子名称: | E3 ubiquitin-protein ligase Mdm2, {(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-[(2S)-1-hydroxybutan-2-yl]-2-oxopiperidin-3-yl}acetic acid | 著者 | Huang, X. | 登録日 | 2012-09-28 | 公開日 | 2012-10-17 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Ordering of the N-terminus of human MDM2 by small molecule inhibitors. J.Am.Chem.Soc., 134, 2012
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4HNF
| Crystal structure of ck1d in complex with pf4800567 | 分子名称: | 3-[(3-chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Casein kinase I isoform delta | 著者 | Huang, X, Long, A.M, Zhao, H. | 登録日 | 2012-10-19 | 公開日 | 2012-11-14 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | Structural basis for the potent and selective inhibition of casein kinase 1 epsilon. J.Med.Chem., 55, 2012
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4HOK
| crystal structure of apo ck1e | 分子名称: | Casein kinase I isoform epsilon, SULFATE ION | 著者 | Huang, X, Long, A.M, Zhao, H. | 登録日 | 2012-10-22 | 公開日 | 2012-11-14 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | 主引用文献 | Structural basis for the potent and selective inhibition of casein kinase 1 epsilon. J.Med.Chem., 55, 2012
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4HNI
| crystal structure of ck1e in complex with PF4800567 | 分子名称: | 3-[(3-chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Casein kinase I isoform epsilon, SULFATE ION | 著者 | Huang, X, Long, A.M, Zhao, H. | 登録日 | 2012-10-19 | 公開日 | 2012-11-14 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | 主引用文献 | Structural basis for the potent and selective inhibition of casein kinase 1 epsilon. J.Med.Chem., 55, 2012
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4I9I
| Crystal structure of tankyrase 1 with compound 4 | 分子名称: | N-(2-methoxyphenyl)-4-{[3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanoyl]amino}benzamide, Tankyrase-1, ZINC ION | 著者 | Huang, X. | 登録日 | 2012-12-05 | 公開日 | 2013-02-06 | 最終更新日 | 2013-05-22 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Discovery of a class of novel tankyrase inhibitors that bind to both the nicotinamide pocket and the induced pocket. J.Med.Chem., 56, 2013
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3UZP
| crystal structure of ck1d with PF670462 from P21 crystal form | 分子名称: | 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyrimidin-2-amine, Casein kinase I isoform delta | 著者 | Huang, X. | 登録日 | 2011-12-07 | 公開日 | 2012-01-11 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Structural basis for the interaction between casein kinase 1 delta and a potent and selective inhibitor. J.Med.Chem., 55, 2012
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3UYT
| crystal structure of ck1d with PF670462 from P1 crystal form | 分子名称: | 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyrimidin-2-amine, Casein kinase I isoform delta, SULFATE ION | 著者 | Huang, X. | 登録日 | 2011-12-06 | 公開日 | 2012-01-11 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis for the interaction between casein kinase 1 delta and a potent and selective inhibitor. J.Med.Chem., 55, 2012
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3UYS
| Crystal structure of apo human ck1d | 分子名称: | Casein kinase I isoform delta, SULFATE ION | 著者 | Huang, X. | 登録日 | 2011-12-06 | 公開日 | 2012-01-11 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural basis for the interaction between casein kinase 1 delta and a potent and selective inhibitor. J.Med.Chem., 55, 2012
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2OFV
| crystal structure of aminoquinazoline 1 bound to Lck | 分子名称: | 3-(2-AMINOQUINAZOLIN-6-YL)-4-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE, Proto-oncogene tyrosine-protein kinase LCK | 著者 | Huang, X. | 登録日 | 2007-01-04 | 公開日 | 2007-02-27 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Discovery of Aminoquinazolines as Potent, Orally Bioavailable Inhibitors of Lck: Synthesis, SAR, and in Vivo Anti-Inflammatory Activity J.Med.Chem., 49, 2006
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6CZS
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2OFU
| x-ray crystal structure of 2-aminopyrimidine carbamate 43 bound to Lck | 分子名称: | 2,6-DIMETHYLPHENYL 2-(3,5-DIMETHOXY-4-(3-(4-METHYLPIPERAZIN-1-YL)PROPOXY)PHENYLAMINO)PYRIMIDIN- 4-YL(2,4-DIMETHOXYPHENYL)CARBAMATE, Proto-oncogene tyrosine-protein kinase LCK, SULFATE ION | 著者 | Huang, X. | 登録日 | 2007-01-04 | 公開日 | 2007-02-27 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Novel 2-Aminopyrimidine Carbamates as Potent and Orally Active Inhibitors of Lck: Synthesis, SAR, and in Vivo Antiinflammatory Activity J.Med.Chem., 49, 2006
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2OG8
| crystal structure of aminoquinazoline 36 bound to Lck | 分子名称: | N-{2-[(N,N-DIETHYLGLYCYL)AMINO]-5-(TRIFLUOROMETHYL)PHENYL}-4-METHYL-3-[2-(METHYLAMINO)QUINAZOLIN-6-YL]BENZAMIDE, Proto-oncogene tyrosine-protein kinase LCK | 著者 | Huang, X. | 登録日 | 2007-01-05 | 公開日 | 2007-02-27 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Discovery of Aminoquinazolines as Potent, Orally Bioavailable Inhibitors of Lck: Synthesis, SAR, and in Vivo Anti-Inflammatory Activity J.Med.Chem., 49, 2006
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6CZK
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3O89
| Crystal Structure of Sperm Whale Myoglobin G65T | 分子名称: | Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION | 著者 | Huang, X, Lovelace, L, Lebioda, L. | 登録日 | 2010-08-02 | 公開日 | 2011-12-07 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Investigations of Structural Factors that Influence the Mechanism of Halophenol Dehalogenation using 'Peroxidase-Like' Myoglobin mutants and 'Myoglobin-Like' Amphitrite ornata Dehaloperoxidase Mutants TO BE PUBLISHED
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3TJC
| Co-crystal structure of jak2 with thienopyridine 8 | 分子名称: | 4-amino-N-methyl-2-[4-(morpholin-4-yl)phenyl]thieno[3,2-c]pyridine-7-carboxamide, Tyrosine-protein kinase JAK2 | 著者 | Huang, X. | 登録日 | 2011-08-24 | 公開日 | 2011-11-30 | 最終更新日 | 2011-12-28 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Discovery of potent and highly selective thienopyridine janus kinase 2 inhibitors. J.Med.Chem., 54, 2011
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3TJD
| co-crystal structure of Jak2 with thienopyridine 19 | 分子名称: | 4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-methylthieno[3,2-c]pyridine-7-carboxamide, Tyrosine-protein kinase JAK2 | 著者 | Huang, X. | 登録日 | 2011-08-24 | 公開日 | 2011-11-30 | 最終更新日 | 2011-12-28 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Discovery of potent and highly selective thienopyridine janus kinase 2 inhibitors. J.Med.Chem., 54, 2011
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6M54
| Human apo ferritin frozen on TEM grid with Amorphous nickel titanium alloy supporting film | 分子名称: | FE (II) ION, Ferritin heavy chain | 著者 | Huang, X, Zhang, L, Wen, Z, Chen, H, Li, S, Ji, G, Yin, C, Sun, F. | 登録日 | 2020-03-09 | 公開日 | 2020-05-13 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Amorphous nickel titanium alloy film: A new choice for cryo electron microscopy sample preparation. Prog.Biophys.Mol.Biol., 156, 2020
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6M52
| Human apo ferritin frozen on TEM grid with amorphous carbon supporting film | 分子名称: | FE (II) ION, Ferritin heavy chain | 著者 | Huang, X, Zhang, L, Wen, Z, Chen, H, Li, S, Ji, G, Yin, C, Sun, F. | 登録日 | 2020-03-09 | 公開日 | 2020-05-13 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Amorphous nickel titanium alloy film: A new choice for cryo electron microscopy sample preparation. Prog.Biophys.Mol.Biol., 156, 2020
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6O4U
| Co-crystal structure of Mcl1 with inhibitor | 分子名称: | (2~{S})-4-(cyclobutylmethyl)-2-(2,4-dichlorophenyl)-~{N}-(2-methylpropylsulfonyl)-2,3-dihydro-1,4-benzoxazine-6-carboxamide, Induced myeloid leukemia cell differentiation protein Mcl-1 | 著者 | Huang, X. | 登録日 | 2019-03-01 | 公開日 | 2020-03-04 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Conformational Restriction Toward the Discovery of Macrocyclic MCL1 Inhibitors that Display Efficacy in Mouse Xenograft Models To Be Published
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8I3A
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8I3B
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8I39
| Cryo-EM structure of abscisic acid transporter AtABCG25 with ABA | 分子名称: | (2Z,4E)-5-[(1S)-1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta-2,4-dienoic acid, ABC transporter G family member 25 | 著者 | Huang, X, Zhang, X, Zhang, P. | 登録日 | 2023-01-16 | 公開日 | 2023-09-13 | 最終更新日 | 2023-11-01 | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | 主引用文献 | Cryo-EM structure and molecular mechanism of abscisic acid transporter ABCG25. Nat.Plants, 9, 2023
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8I3C
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8I38
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8I3D
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