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PDB: 194 件

8KC7
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Rpd3S histone deacetylase complex
分子名称: Chromatin modification-related protein EAF3, Histone deacetylase RPD3, Transcriptional regulatory protein RCO1, ...
著者Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Zhang, X, Chao, W.C.H, He, J.
登録日2023-08-06
公開日2023-09-13
最終更新日2023-10-18
実験手法ELECTRON MICROSCOPY (3.46 Å)
主引用文献Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex.
Cell Res., 33, 2023
8KD4
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Rpd3S in complex with nucleosome with H3K36MLA modification and 187bp DNA, class1
分子名称: 187bp DNA, Chromatin modification-related protein EAF3, Histone H2A, ...
著者Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Zhang, X, Chao, W.C.H, He, J.
登録日2023-08-09
公開日2023-09-13
最終更新日2023-10-11
実験手法ELECTRON MICROSCOPY (2.93 Å)
主引用文献Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex.
Cell Res., 33, 2023
8KD6
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Rpd3S in complex with nucleosome with H3K36MLA modification and 187bp DNA, class3
分子名称: 187bp DNA, Chromatin modification-related protein EAF3, Histone H2A, ...
著者Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Zhang, X, Chao, W.C.H, He, J.
登録日2023-08-09
公開日2023-09-13
最終更新日2023-10-11
実験手法ELECTRON MICROSCOPY (3.07 Å)
主引用文献Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex.
Cell Res., 33, 2023
8KD7
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Rpd3S in complex with nucleosome with H3K36MLA modification and 167bp DNA
分子名称: 167bp DNA, Chromatin modification-related protein EAF3, Histone H2A, ...
著者Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Chang, X, Chao, W.C.H, He, J.
登録日2023-08-09
公開日2023-09-13
最終更新日2023-10-11
実験手法ELECTRON MICROSCOPY (3.09 Å)
主引用文献Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex.
Cell Res., 33, 2023
4G6F
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Crystal Structure of 10E8 Fab in Complex with an HIV-1 gp41 Peptide
分子名称: 10E8 Heavy Chain, 10E8 Light Chain, gp41 MPER Peptide
著者Ofek, G, Huang, J, Connors, M, Kwong, P.D.
登録日2012-07-19
公開日2012-09-26
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Broad and potent neutralization of HIV-1 by a gp41-specific human antibody.
Nature, 491, 2012
5HC2
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Structure of esterase Est22 mutant-S188A with p-nitrophenol
分子名称: IMIDAZOLE, Lipolytic enzyme, P-NITROPHENOL
著者Li, J, Huang, J.
登録日2016-01-04
公開日2017-01-18
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.986 Å)
主引用文献Structural insights of a hormone sensitive lipase homologue Est22.
Sci Rep, 6, 2016
5HC0
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Structure of esterase Est22 with p-nitrophenol
分子名称: ACETIC ACID, GLYCEROL, Lipolytic enzyme, ...
著者Li, J, Huang, J.
登録日2016-01-04
公開日2017-01-18
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structural insights of a hormone sensitive lipase homologue Est22.
Sci Rep, 6, 2016
5HC3
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The structure of esterase Est22
分子名称: GLYCEROL, Lipolytic enzyme
著者Li, J, Huang, J.
登録日2016-01-04
公開日2017-01-18
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural insights of a hormone sensitive lipase homologue Est22.
Sci Rep, 6, 2016
5HC5
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The structure of esterase Est22 mutant-S188A
分子名称: Lipolytic enzyme
著者Li, J, Huang, J.
登録日2016-01-04
公開日2017-01-18
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.43 Å)
主引用文献Structural insights of a hormone sensitive lipase homologue Est22.
Sci Rep, 6, 2016
4IFT
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BU of 4ift by Molmil
Crystal structure of double mutant thermostable NPPase from Geobacillus stearothermophilus
分子名称: Thermostable NPPase
著者Guo, Z, Huang, J, Wang, F, Qiu, R, Wang, Y, Ji, C.
登録日2012-12-15
公開日2013-12-18
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.995 Å)
主引用文献Crystal structure of thermostable NPPase from Geobacillus stearothermophilus
To be Published
5HC4
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Structure of esterase Est22
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, Lipolytic enzyme
著者Li, J, Huang, J.
登録日2016-01-04
公開日2017-01-18
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural insights of a hormone sensitive lipase homologue Est22.
Sci Rep, 6, 2016
4IG4
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Crystal structure of single mutant thermostable NPPase (N86S) from Geobacillus stearothermophilus
分子名称: Thermostable NPPase
著者Guo, Z, Wang, F, Huang, J, Qiu, R, Yang, Z, Wang, Y, Gong, W, Ji, C.
登録日2012-12-16
公開日2013-12-18
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.402 Å)
主引用文献Crystal structure of thermostable NPPase from Geobacillus stearothermophilus
To be Published
3CH8
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BU of 3ch8 by Molmil
The crystal structure of PDZ-Fibronectin fusion protein
分子名称: C-terminal octapeptide from protein ARVCF, MAGNESIUM ION, fusion protein PDZ-Fibronectin,Fibronectin
著者Makabe, K, Huang, J, Koide, A, Koide, S.
登録日2008-03-08
公開日2009-03-31
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural basis for exquisite specificity of affinity clamps, synthetic binding proteins generated through directed domain-interface evolution.
J.Mol.Biol., 392, 2009
8IQ6
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Cryo-EM structure of Latanoprost-bound prostaglandin-F2-alpha receptor-miniGq-Nb35 complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
著者Lv, X, Gao, K, Nie, J, Zhang, X, Zhang, S, Ren, Y, Li, Q, Huang, J, Liu, L, Zhang, X, Sun, X, Zhang, W, Liu, X.
登録日2023-03-15
公開日2024-01-31
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structures of human prostaglandin F 2 alpha receptor reveal the mechanism of ligand and G protein selectivity.
Nat Commun, 14, 2023
8IQ4
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Cryo-EM structure of Carboprost-bound prostaglandin-F2-alpha receptor-miniGq-Nb35 complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
著者Lv, X, Gao, K, Nie, J, Zhang, X, Zhang, S, Ren, Y, Li, Q, Huang, J, Liu, L, Zhang, X, Sun, X, Zhang, W, Liu, X.
登録日2023-03-15
公開日2024-01-31
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Structures of human prostaglandin F 2 alpha receptor reveal the mechanism of ligand and G protein selectivity.
Nat Commun, 14, 2023
8G1A
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BU of 8g1a by Molmil
Cryo-EM structure of Nav1.7 with CBD
分子名称: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ...
著者Fan, X, Huang, J, Yan, N.
登録日2023-02-01
公開日2023-07-05
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Cannabidiol inhibits Na v channels through two distinct binding sites.
Nat Commun, 14, 2023
8FHD
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BU of 8fhd by Molmil
Cryo-EM structure of human voltage-gated sodium channel Nav1.6
分子名称: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, (5E,17R,20S)-23-amino-20-hydroxy-14,20-dioxo-15,19,21-trioxa-20lambda~5~-phosphatricos-5-en-17-yl hexadecanoate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ...
著者Fan, X, Huang, J, Yan, N.
登録日2022-12-14
公開日2023-02-08
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Cryo-EM structure of human voltage-gated sodium channel Na v 1.6.
Proc.Natl.Acad.Sci.USA, 120, 2023
5ZG9
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BU of 5zg9 by Molmil
Crystal structure of MoSub1-ssDNA complex in phosphate buffer
分子名称: DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*G)-3'), MoSub1, PHOSPHATE ION
著者Zhao, Y, Huang, J, Liu, H, Yi, L, Wang, S, Zhang, X, Liu, J.
登録日2018-03-08
公開日2019-03-27
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献The effect of phosphate ion on the ssDNA binding mode of MoSub1, a Sub1/PC4 homolog from rice blast fungus.
Proteins, 87, 2019
3J1T
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BU of 3j1t by Molmil
High affinity dynein microtubule binding domain - tubulin complex
分子名称: Cytoplasmic dynein 1 heavy chain 1, seryl t-RNA synthetase chimera, Tubulin alpha-1B chain, ...
著者Redwine, W.B, Hernandez-Lopez, R, Zou, S, Huang, J, Reck-Peterson, S.L, Leschziner, A.E.
登録日2012-06-25
公開日2012-09-26
最終更新日2024-02-21
実験手法ELECTRON MICROSCOPY (9.7 Å)
主引用文献Structural basis for microtubule binding and release by dynein.
Science, 337, 2012
3J1U
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Low affinity dynein microtubule binding domain - tubulin complex
分子名称: Cytoplasmic dynein 1 heavy chain 1, seryl t-RNA synthetase chimera, Tubulin alpha-1B chain, ...
著者Redwine, W.B, Hernandez-Lopez, R, Zou, S, Huang, J, Reck-Peterson, S.L, Leschziner, A.E.
登録日2012-06-25
公開日2012-09-26
最終更新日2024-02-21
実験手法ELECTRON MICROSCOPY (9.7 Å)
主引用文献Structural basis for microtubule binding and release by dynein.
Science, 337, 2012
6LZL
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Crystal structure of human dihydroorotate dehydrogenase (DHODH) with Piperine
分子名称: (2E,4E)-5-(2H-1,3-benzodioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one, Dihydroorotate dehydrogenase (quinone), mitochondrial, ...
著者Liu, Z.H, Wu, D, Lu, W.Q, Huang, J.
登録日2020-02-19
公開日2020-04-15
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Crystal structure of human dihydroorotate dehydrogenase (DHODH) with Piperine
To Be Published
6MYV
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Sialidase26 co-crystallized with DANA-Gc
分子名称: 2,6-anhydro-3,5-dideoxy-5-[(hydroxyacetyl)amino]-D-glycero-L-altro-non-2-enonic acid, Sialidase26
著者Zaramela, L.S, Martino, C, Alisson-Silva, F, Rees, S.D, Diaz, S.L, Chuzel, L, Ganatra, M.B, Taron, C.H, Zuniga, C, Huang, J, Siegel, D, Chang, G, Varki, A, Zengler, K.
登録日2018-11-02
公開日2019-10-02
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Gut bacteria responding to dietary change encode sialidases that exhibit preference for red meat-associated carbohydrates.
Nat Microbiol, 4, 2019
4R7L
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Structure of Human Leukotriene A4 Hydrolase in complex with inhibitor H1
分子名称: ACETATE ION, GLYCEROL, IMIDAZOLE, ...
著者Ouyang, P, Cui, K, Lu, W, Huang, J.
登録日2014-08-27
公開日2015-11-25
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.66 Å)
主引用文献Human Leukotriene A4 Hydrolase in complex with SAHA
To be Published
4E9A
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Structure of Peptide Deformylase form Helicobacter Pylori in complex with inhibitor
分子名称: 2-phenylethyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, COBALT (II) ION, ...
著者Cui, K, Zhu, L, Lu, W, Huang, J.
登録日2012-03-20
公開日2013-04-24
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.662 Å)
主引用文献Identification of Novel Peptide Deformylase Inhibitors from Natural Products
To be Published
4CC6
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Fragment-Based Discovery of 6 Azaindazoles As Inhibitors of Bacterial DNA Ligase
分子名称: 2-{[2-(1H-pyrazolo[3,4-c]pyridin-3-yl)-6-(trifluoromethyl)pyridin-4-yl]amino}ethanol, DNA LIGASE, SULFATE ION
著者Howard, S, Amin, N, Benowitz, A.B, Chiarparin, E, Cui, H, Deng, X, Heightman, T.D, Holmes, D.J, Hopkins, A, Huang, J, Jin, Q, Kreatsoulas, C, Martin, A.C.L, Massey, F, McCloskey, L, Mortenson, P.N, Pathuri, P, Tisi, D, Williams, P.A.
登録日2013-10-18
公開日2014-06-18
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Fragment-Based Discovery of 6-Azaindazoles as Inhibitors of Bacterial DNA Ligase.
Acs Med.Chem.Lett., 4, 2013

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