7WJV
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![BU of 7wjv by Molmil](/molmil-images/mine/7wjv) | Crystal structure of human liver FBPase complexed with an covalent inhibitor | 分子名称: | 1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE, ADENOSINE MONOPHOSPHATE, Fructose-1,6-bisphosphatase 1, ... | 著者 | Cao, H, Huang, Y, Ren, Y, Wan, J. | 登録日 | 2022-01-08 | 公開日 | 2022-07-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.724 Å) | 主引用文献 | N -Acylamino Saccharin as an Emerging Cysteine-Directed Covalent Warhead and Its Application in the Identification of Novel FBPase Inhibitors toward Glucose Reduction. J.Med.Chem., 65, 2022
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7F3L
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7F3J
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7F3I
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7F3K
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6KCU
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![BU of 6kcu by Molmil](/molmil-images/mine/6kcu) | Shuguo PWWP domain | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, LD23804p | 著者 | Liu, Y.C, Huang, Y. | 登録日 | 2019-06-29 | 公開日 | 2020-07-01 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Shuguo PWWP domain To Be Published
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6KCO
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6KCP
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6KD6
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7V6G
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![BU of 7v6g by Molmil](/molmil-images/mine/7v6g) | Structure of Candida albicans Fructose-1,6-bisphosphate aldolase mutation C157S with CN39 | 分子名称: | 1,2-ETHANEDIOL, Fructose-bisphosphate aldolase, ZINC ION, ... | 著者 | Cao, H, Huang, Y, Chen, H, Wan, C, Ren, Y, Wan, J. | 登録日 | 2021-08-20 | 公開日 | 2022-02-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.343 Å) | 主引用文献 | Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of Candidiasis. J.Med.Chem., 65, 2022
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7V6F
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![BU of 7v6f by Molmil](/molmil-images/mine/7v6f) | Structure of Candida albicans Fructose-1,6-bisphosphate aldolase complexed with G3P | 分子名称: | Fructose-bisphosphate aldolase, GLYCERALDEHYDE-3-PHOSPHATE, ZINC ION | 著者 | Hongxuan, C, Huang, Y, Han, C, Chen, W, Ren, Y, Wan, J. | 登録日 | 2021-08-20 | 公開日 | 2022-02-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | 主引用文献 | Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of Candidiasis. J.Med.Chem., 65, 2022
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5XYW
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5XYV
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5Z9X
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![BU of 5z9x by Molmil](/molmil-images/mine/5z9x) | Arabidopsis SMALL RNA DEGRADING NUCLEASE 1 in complex with an RNA substrate | 分子名称: | MAGNESIUM ION, RNA (5'-R(P*GP*CP*CP*CP*AP*UP*UP*AP*G)-3'), SULFATE ION, ... | 著者 | Chen, J, Liu, L, You, C, Gu, J, Ruan, W, Zhang, L, Gan, J, Cao, C, Huang, Y, Chen, X, Ma, J. | 登録日 | 2018-02-05 | 公開日 | 2018-06-27 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural and biochemical insights into small RNA 3' end trimming by Arabidopsis SDN1. Nat Commun, 9, 2018
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5X5Y
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![BU of 5x5y by Molmil](/molmil-images/mine/5x5y) | A membrane protein complex | 分子名称: | Probable ATP-binding component of ABC transporter, Uncharacterized protein | 著者 | Luo, Q, Yang, X, Huang, Y. | 登録日 | 2017-02-18 | 公開日 | 2017-04-05 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.465 Å) | 主引用文献 | Structural basis for lipopolysaccharide extraction by ABC transporter LptB2FG Nat. Struct. Mol. Biol., 24, 2017
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5Z9Z
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![BU of 5z9z by Molmil](/molmil-images/mine/5z9z) | The C-terminal RRM domain of Arabidopsis SMALL RNA DEGRADING NUCLEASE 1 (E329A/E330A/E332A) | 分子名称: | CITRATE ANION, Small RNA degrading nuclease 1 | 著者 | Chen, J, Liu, L, You, C, Gu, J, Ruan, W, Zhang, L, Cao, C, Gan, J, Huang, Y, Chen, X, Ma, J. | 登録日 | 2018-02-05 | 公開日 | 2018-06-27 | 最終更新日 | 2018-10-03 | 実験手法 | X-RAY DIFFRACTION (2.049 Å) | 主引用文献 | Structural and biochemical insights into small RNA 3' end trimming by Arabidopsis SDN1. Nat Commun, 9, 2018
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5WY0
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![BU of 5wy0 by Molmil](/molmil-images/mine/5wy0) | Crystal structure of the methyltranferase domain of human HEN1 in complex with AdoMet | 分子名称: | S-ADENOSYLMETHIONINE, Small RNA 2'-O-methyltransferase | 著者 | Peng, L, Ma, J.B, Wu, L.G, Huang, Y. | 登録日 | 2017-01-10 | 公開日 | 2018-01-17 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.001 Å) | 主引用文献 | Identification of substrates of the small RNA methyltransferase Hen1 in mouse spermatogonial stem cells and analysis of its methyl-transfer domain J. Biol. Chem., 293, 2018
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5WP6
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![BU of 5wp6 by Molmil](/molmil-images/mine/5wp6) | Cryo-EM structure of a human TRPM4 channel in complex with calcium and decavanadate | 分子名称: | DECAVANADATE, Transient receptor potential cation channel subfamily M member 4 | 著者 | Winkler, P.A, Huang, Y, Sun, W, Du, J, Lu, W. | 登録日 | 2017-08-03 | 公開日 | 2017-12-13 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Electron cryo-microscopy structure of a human TRPM4 channel. Nature, 552, 2017
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5ZUM
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![BU of 5zum by Molmil](/molmil-images/mine/5zum) | Structure of dipeptidyl-peptidase III from Corallococcus sp. strain EGB | 分子名称: | ZINC ION, dipeptidyl-peptidase III | 著者 | Zhang, H, Duan, Y.J, Li, Z.K, Liu, W.D, Huang, Y, Cui, Z.L. | 登録日 | 2018-05-08 | 公開日 | 2019-06-12 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure of dipeptidyl peptidase III from Corallococcus sp. strain EGB To Be Published
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6A6O
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![BU of 6a6o by Molmil](/molmil-images/mine/6a6o) | Crystal structure of acetyl ester-xyloside bifunctional hydrolase from Caldicellulosiruptor lactoaceticus | 分子名称: | Esterase/lipase-like protein | 著者 | Cao, H, Huang, Y, Sun, L.C, Liu, X, Liu, T.F, Wang, F.Z, Xin, F.J. | 登録日 | 2018-06-28 | 公開日 | 2019-06-12 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural Insights into the Dual-Substrate Recognition and Catalytic Mechanisms of a Bifunctional Acetyl Ester-Xyloside Hydrolase from Caldicellulosiruptor lactoaceticus. Acs Catalysis, 9, 2019
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8H4R
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![BU of 8h4r by Molmil](/molmil-images/mine/8h4r) | The Crystal Structure of CDK3 and CyclinE1 Complex with Dinaciclib from Biortus | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium, G1/S-specific cyclin-E1, ... | 著者 | Gui, W, Wang, F, Cheng, W, Gao, J, Huang, Y, Ouyang, Z. | 登録日 | 2022-10-11 | 公開日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | The Crystal Structure of CDK3 and CyclinE1 Complex with Dinaciclib from Biortus To Be Published
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8IZ9
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![BU of 8iz9 by Molmil](/molmil-images/mine/8iz9) | cryo-EM structure of PGE1-bound hMRP4 | 分子名称: | 7-[(1R,3R)-3-hydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopentyl]heptanoic acid, ATP-binding cassette sub-family C member 4 | 著者 | Liu, Z.M, Huang, Y. | 登録日 | 2023-04-06 | 公開日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | 主引用文献 | cryo-EM structure of PGE1-bound hMRP4 To Be Published
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8IZA
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8IA5
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![BU of 8ia5 by Molmil](/molmil-images/mine/8ia5) | Small peptide enhances the binding of nutline-3a to N-terminal domain of MdmX | 分子名称: | 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, 9-mer peptide, ... | 著者 | Cheng, X.Y, Wei, Q.Y, Huang, Y, Su, Z.D. | 登録日 | 2023-02-07 | 公開日 | 2023-02-22 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Small peptide enhances the binding of nutline-3a to N-terminal domain of MdmX To Be Published
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8IZ8
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