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PDB: 35 件
8W68
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Crystal structure of Q9PR55 at pH 6.0 (use NMR model)
分子名称: Uncharacterized protein UU089.1
著者Hsu, M.F, Ko, T.P, Huang, K.F, Chen, Y.R, Huang, J.S, Hsu, S.T.D.
登録日2023-08-28
公開日2024-02-07
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure, dynamics, and stability of the smallest and most complex 7 1 protein knot.
J.Biol.Chem., 300, 2023
8IWC
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BU of 8iwc by Molmil
Crystal structure of Q9PR55 at pH 6.0
分子名称: Uncharacterized protein UU089.1
著者Hsu, M.F, Ko, T.P, Huang, K.F, Chen, Y.R, Huang, J.S, Hsu, S.T.D.
登録日2023-03-29
公開日2024-02-07
実験手法X-RAY DIFFRACTION (2.43 Å)
主引用文献Structure, dynamics, and stability of the smallest and most complex 7 1 protein knot.
J.Biol.Chem., 300, 2023
8IWA
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BU of 8iwa by Molmil
Crystal structure of Q9PR55 at pH 6.5
分子名称: SULFATE ION, Uncharacterized protein UU089.1
著者Hsu, M.F, Ko, T.P, Huang, K.F, Chen, Y.R, Huang, J.S, Hsu, S.T.D.
登録日2023-03-29
公開日2024-02-07
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Structure, dynamics, and stability of the smallest and most complex 7 1 protein knot.
J.Biol.Chem., 300, 2023
8IWB
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BU of 8iwb by Molmil
Crystal structure of Q9PR55 at pH 7.5
分子名称: Uncharacterized protein UU089.1
著者Hsu, M.F, Ko, T.P, Huang, K.F, Chen, Y.R, Huang, J.S, Hsu, S.T.D.
登録日2023-03-29
公開日2024-02-07
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献Structure, dynamics, and stability of the smallest and most complex 7 1 protein knot.
J.Biol.Chem., 300, 2023
3KCW
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BU of 3kcw by Molmil
Crystal structure of Ganoderma fungal immunomodulatory protein, GMI
分子名称: immunomodulatory protein
著者Hsu, M.F, Wang, A.H.J, Yang, C.S, Huang, C.T, Hseu, R.S, Lin, C.W, Wu, M.Y, Huang, C.S, Fu, H.Y.
登録日2009-10-22
公開日2010-11-03
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Single cysteine replacement at Leu6 increase the potent and thermostability in Ganoderma fungal immunomodulatory proteins
To be Published
2GX4
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BU of 2gx4 by Molmil
Crystal structure of SARS coronavirus 3CL protease inhibitor complex
分子名称: 3C-like proteinase, N-[(BENZYLOXY)CARBONYL]-O-(TERT-BUTYL)-L-THREONYL-3-CYCLOHEXYL-N-[(1S)-2-HYDROXY-1-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}ETHYL]-L-ALANINAMIDE
著者Hsu, M.F, Wang, A.H.-J.
登録日2006-05-08
公開日2007-05-08
最終更新日2020-04-08
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Synthesis, crystal structure, structure-activity relationships, and antiviral activity of a potent SARS coronavirus 3CL protease inhibitor.
J.Med.Chem., 49, 2006
8SG5
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Cytochrome P450 (CYP) 3A5 crystallized with clotrimazole
分子名称: 1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE, Cytochrome P450 3A5, DODECYL NONA ETHYLENE GLYCOL ETHER, ...
著者Hsu, M.H, Johnson, E.F.
登録日2023-04-11
公開日2023-10-11
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Differential Effects of Clotrimazole on X-Ray Crystal Structures of Human Cytochromes P450 3A5 and 3A4.
Drug Metab.Dispos., 51, 2023
6C93
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Effects of the E310A Mutation of Cytochrome P450 4B1 (CYP4B1) on n-Octane binding and Heme Ruffling
分子名称: Cytochrome P450 4B1, N-OCTANE, PROTOPORPHYRIN IX CONTAINING FE
著者Hsu, M.-H, Johnson, E.F.
登録日2018-01-25
公開日2018-06-20
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.674 Å)
主引用文献Noncovalent interactions dominate dynamic heme distortion in cytochrome P450 4B1.
J. Biol. Chem., 293, 2018
6C94
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Structure Of Cytochrome P450 4B1 (CYP4B1) Complexed with the Inhibitor HET0016
分子名称: Cytochrome P450 4B1, N-(4-butyl-2-methylphenyl)-N'-hydroxyimidoformamide, PROTOPORPHYRIN IX CONTAINING FE
著者Hsu, M.-H, Johnson, E.F.
登録日2018-01-25
公開日2018-06-20
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.72 Å)
主引用文献Noncovalent interactions dominate dynamic heme distortion in cytochrome P450 4B1.
J. Biol. Chem., 293, 2018
5TFU
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BU of 5tfu by Molmil
Structure of cytochrome P450 2D6 (CYP2D6) BACE1 inhibitor complex
分子名称: (4S,6R)-4-[2,4-difluoro-5-({[1-(trifluoromethyl)cyclopropyl]amino}methyl)phenyl]-4,6-dimethyl-5,6-dihydro-4H-1,3-thiazin-2-amine, Cytochrome P450 2D6, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Hsu, M.H, Johnson, E.F.
登録日2016-09-26
公開日2017-01-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality.
J. Med. Chem., 60, 2017
5T6Q
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Structure of cytochrome P450 4B1 (CYP4B1) complexed with octane: An n-Alkane and fatty acid omega-hydroxylase with a covalently bound heme
分子名称: Cytochrome P450 4B1, N-OCTANE, PROTOPORPHYRIN IX CONTAINING FE
著者Hsu, M, Johnson, E.F.
登録日2016-09-01
公開日2017-02-15
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.701 Å)
主引用文献The Crystal Structure of Cytochrome P450 4B1 (CYP4B1) Monooxygenase Complexed with Octane Discloses Several Structural Adaptations for omega-Hydroxylation.
J. Biol. Chem., 292, 2017
5TFT
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BU of 5tft by Molmil
Structure of cytochrome P450 2D6 (CYP2D6) BACE1 inhibitor complex
分子名称: (4S)-4-[2,4-difluoro-5-({[1-(trifluoromethyl)cyclopropyl]amino}methyl)phenyl]-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine, Cytochrome P450 2D6, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Hsu, M.H, Johnson, E.F.
登録日2016-09-26
公開日2017-01-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.71 Å)
主引用文献Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality.
J. Med. Chem., 60, 2017
8SPD
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BU of 8spd by Molmil
Cytochrome P450 (CYP) 3A4 crystallized with clotrimazole
分子名称: 1-[(2-CHLOROPHENYL)(DIPHENYL)METHYL]-1H-IMIDAZOLE, Cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE
著者Hsu, M.H, Johnson, E.F.
登録日2023-05-02
公開日2023-10-11
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Differential Effects of Clotrimazole on X-Ray Crystal Structures of Human Cytochromes P450 3A5 and 3A4.
Drug Metab.Dispos., 51, 2023
2ZU4
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BU of 2zu4 by Molmil
Complex structure of SARS-CoV 3CL protease with TG-0204998
分子名称: 3C-like proteinase, N-[(benzyloxy)carbonyl]-3-[(2,2-dimethylpropanoyl)amino]-L-alanyl-N-[(1R)-4-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}pentyl]-L-leucinamide
著者Hsu, M.F, Lee, C.C, Wang, A.H.-J.
登録日2008-10-12
公開日2009-01-13
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Structural Basis of Inhibition Specificities of 3C and 3C-like Proteases by Zinc-coordinating and Peptidomimetic Compounds
J.Biol.Chem., 284, 2009
2ZU5
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BU of 2zu5 by Molmil
complex structure of SARS-CoV 3CL protease with TG-0205486
分子名称: 3C-like proteinase, N-[(benzyloxy)carbonyl]-O-tert-butyl-L-threonyl-N-[(1R)-4-cyclopropyl-4-oxo-1-{[(3S)-2-oxopyrrolidin-3-yl]methyl}butyl]-L-leucinamide
著者Hsu, M.F, Lee, C.C, Wang, A.H.-J.
登録日2008-10-12
公開日2009-01-13
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structural Basis of Inhibition Specificities of 3C and 3C-like Proteases by Zinc-coordinating and Peptidomimetic Compounds
J.Biol.Chem., 284, 2009
5VEU
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BU of 5veu by Molmil
Human Cytochrome P450 3A5 (CYP3A5)
分子名称: Cytochrome P450 3A5, PROTOPORPHYRIN IX CONTAINING FE, RITONAVIR
著者Hsu, M.-H, Johnson, E.F.
登録日2017-04-05
公開日2017-11-15
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.91 Å)
主引用文献The X-Ray Crystal Structure of the Human Mono-Oxygenase Cytochrome P450 3A5-Ritonavir Complex Reveals Active Site Differences between P450s 3A4 and 3A5.
Mol. Pharmacol., 93, 2018
1Z1J
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BU of 1z1j by Molmil
Crystal structure of SARS 3CLpro C145A mutant
分子名称: 3C-like proteinase
著者Hsu, M.F.
登録日2005-03-04
公開日2005-11-22
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Understanding the maturation process and inhibitor design of SARS-CoV 3CLpro from the crystal structure of C145A in a product-bound form
J.Biol.Chem., 280, 2005
6MJM
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BU of 6mjm by Molmil
Substrate Free Cytochrome P450 3A5 (CYP3A5)
分子名称: Cytochrome P450 3A5, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE
著者Hsu, M.H, Johnson, E.F.
登録日2018-09-21
公開日2019-04-03
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Active-site differences between substrate-free and ritonavir-bound cytochrome P450 (CYP) 3A5 reveal plasticity differences between CYP3A5 and CYP3A4.
J.Biol.Chem., 294, 2019
7SV2
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BU of 7sv2 by Molmil
Human Cytochrome P450 (CYP) 3A5 ternary complex with azamulin
分子名称: (3aS,4R,5S,6R,8R,9R,9aR,10R)-6-ethyl-5-hydroxy-4,6,9,10-tetramethyl-1-oxodecahydro-3a,9-propanocyclopenta[8]annulen-8-yl [(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]acetate, Cytochrome P450 3A5, PROTOPORPHYRIN IX CONTAINING FE
著者Hsu, M, Johnson, E.F.
登録日2021-11-18
公開日2022-05-18
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.46 Å)
主引用文献Structural characterization of the homotropic cooperative binding of azamulin to human cytochrome P450 3A5.
J.Biol.Chem., 298, 2022
4WAV
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BU of 4wav by Molmil
Crystal Structure of Haloquadratum walsbyi bacteriorhodopsin mutant D93N
分子名称: Bacteriorhodopsin-I, RETINAL, [(Z)-octadec-9-enyl] (2R)-2,3-bis(oxidanyl)propanoate
著者Wang, A.H.J, Hsu, M.F, Yang, C.S, Fu, H.Y.
登録日2014-09-02
公開日2015-09-23
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of an acid-tolerant light-driven proton pump at 1.85 Angstroms resolution
To be published
3GD0
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BU of 3gd0 by Molmil
Crystal structure of laminaripentaose-producing beta-1,3-glucanase
分子名称: Laminaripentaose-producing beta-1,3-guluase (LPHase)
著者Wu, H.M, Hsu, M.T, Liu, S.W, Lai, C.C, Li, Y.K, Wang, W.C.
登録日2009-02-23
公開日2009-07-28
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Structure, mechanistic action, and essential residues of a GH-64 enzyme, laminaripentaose-producing beta-1,3-glucanase.
J.Biol.Chem., 284, 2009
3GD9
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BU of 3gd9 by Molmil
Crystal structure of laminaripentaose-producing beta-1,3-glucanase in complex with laminaritetraose
分子名称: Laminaripentaose-producing beta-1,3-guluase (LPHase), beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-3)-beta-D-glucopyranose-(1-3)-alpha-D-glucopyranose
著者Wu, H.M, Hsu, M.T, Liu, S.W, Lai, C.C, Li, Y.K, Wang, W.C.
登録日2009-02-23
公開日2009-07-28
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure, mechanistic action, and essential residues of a GH-64 enzyme, laminaripentaose-producing beta-1,3-glucanase.
J.Biol.Chem., 284, 2009
5W0C
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BU of 5w0c by Molmil
Cytochrome P450 (CYP) 2C9 TCA007 Inhibitor Complex
分子名称: Cytochrome P450 2C9, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Johnson, E.F, Hsu, M.-H.
登録日2017-05-30
公開日2017-09-13
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.001 Å)
主引用文献Determinants of the Inhibition of DprE1 and CYP2C9 by Antitubercular Thiophenes.
Angew. Chem. Int. Ed. Engl., 56, 2017
2GL1
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BU of 2gl1 by Molmil
NMR solution structure of Vigna radiata Defensin 2 (VrD2)
分子名称: PDF1
著者Lin, K.F, Lee, T.R, Tsai, P.H, Hsu, M.P, Chen, C.S, Lyu, P.C.
登録日2006-04-04
公開日2007-04-03
最終更新日2022-03-09
実験手法SOLUTION NMR
主引用文献Structure-based protein engineering for alpha-amylase inhibitory activity of plant defensin.
Proteins, 68, 2007
1Z11
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BU of 1z11 by Molmil
Crystal Structure of Human Microsomal P450 2A6 with Methoxsalen Bound
分子名称: METHOXSALEN, PROTOPORPHYRIN IX CONTAINING FE, cytochrome P450, ...
著者Yano, J.K, Hsu, M.H, Griffin, K.J, Stout, C.D, Johnson, E.F.
登録日2005-03-02
公開日2005-08-16
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen
Nat.Struct.Mol.Biol., 12, 2005

 

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