7SV2

Human Cytochrome P450 (CYP) 3A5 ternary complex with azamulin

Summary for 7SV2

Entry DOI	10.2210/pdb7sv2/pdb
Descriptor	Cytochrome P450 3A5, PROTOPORPHYRIN IX CONTAINING FE, (3aS,4R,5S,6R,8R,9R,9aR,10R)-6-ethyl-5-hydroxy-4,6,9,10-tetramethyl-1-oxodecahydro-3a,9-propanocyclopenta[8]annulen-8-yl [(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]acetate, ... (4 entities in total)
Functional Keywords	inhibitor, complex, binding properties, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	225745.48
Authors	Hsu, M.,Johnson, E.F. (deposition date: 2021-11-18, release date: 2022-05-18, Last modification date: 2023-10-18)
Primary citation	Hsu, M.H.,Johnson, E.F. Structural characterization of the homotropic cooperative binding of azamulin to human cytochrome P450 3A5. J.Biol.Chem., 298:101909-101909, 2022 Cited by PubMed: 35398097 DOI: 10.1016/j.jbc.2022.101909 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.46 Å)

Structure validation