7SV2
Human Cytochrome P450 (CYP) 3A5 ternary complex with azamulin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Cytochrome P450 3A5 | polymer | 480 | 54862.6 | 4 | UniProt (P20815) Pfam (PF00067) | Homo sapiens (Human) | CYPIIIA5,Cytochrome P450 HLp2,Cytochrome P450-PCN3 |
| 2 | E, H, K, N (A, B, C, D) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
| 3 | F, G, I, J, L... (A, B, C, D) | (3aS,4R,5S,6R,8R,9R,9aR,10R)-6-ethyl-5-hydroxy-4,6,9,10-tetramethyl-1-oxodecahydro-3a,9-propanocyclopenta[8]annulen-8-yl [(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]acetate | non-polymer | 478.6 | 8 | Chemie (MWY) | |||
| 4 | Q, R, S, T (A, B, C, D) | water | water | 18.0 | 128 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 24 - 497 (UniProt: P20815)
| PDB | External Database | Details |
|---|---|---|
| Met 22 | - | initiating methionine |
| Ala 23 | - | expression tag |
| His 498 | - | expression tag |
| His 499 | - | expression tag |
| His 500 | - | expression tag |
| His 501 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 219450.3 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 6295.1 | |
| All* | Total formula weight | 225745.5 |
