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PDB: 177 件
7Y1J
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Structure of SUR2A in complex with Mg-ATP and repaglinide in the inward-facing conformation.
分子名称: ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 9, MAGNESIUM ION, ...
著者Chen, L, Ding, D, Hou, T.
登録日2022-06-08
公開日2023-06-14
最終更新日2023-10-11
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献The inhibition mechanism of the SUR2A-containing K ATP channel by a regulatory helix.
Nat Commun, 14, 2023
7Y1K
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Structure of SUR2A in complex with Mg-ATP, Mg-ADP and repaglinide in the inward-facing conformation
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 9, ...
著者Chen, L, Ding, D, Hou, T.
登録日2022-06-08
公開日2023-06-14
最終更新日2023-10-11
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献The inhibition mechanism of the SUR2A-containing K ATP channel by a regulatory helix.
Nat Commun, 14, 2023
7Y1L
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Structure of SUR2B in complex with Mg-ATP and repaglinide in the inward-facing conformation
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Isoform SUR2B of ATP-binding cassette sub-family C member 9, MAGNESIUM ION, ...
著者Chen, L, Ding, D, Hou, T.
登録日2022-06-08
公開日2023-06-14
最終更新日2023-10-11
実験手法ELECTRON MICROSCOPY (3.73 Å)
主引用文献The inhibition mechanism of the SUR2A-containing K ATP channel by a regulatory helix.
Nat Commun, 14, 2023
7Y1M
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Structure of SUR2B in complex with Mg-ATP, Mg-ADP, and repaglinide in the inward-facing conformation
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Isoform SUR2B of ATP-binding cassette sub-family C member 9, ...
著者Chen, L, Ding, D, Hou, T.
登録日2022-06-08
公開日2023-06-14
最終更新日2023-10-11
実験手法ELECTRON MICROSCOPY (3.57 Å)
主引用文献The inhibition mechanism of the SUR2A-containing K ATP channel by a regulatory helix.
Nat Commun, 14, 2023
7Y1N
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Structure of SUR2B in complex with Mg-ATP, Mg-ADP, and repaglinide in the partially occluded state
分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Isoform SUR2B of ATP-binding cassette sub-family C member 9, ...
著者Chen, L, Ding, D, Hou, T.
登録日2022-06-08
公開日2023-06-14
最終更新日2023-10-11
実験手法ELECTRON MICROSCOPY (3.61 Å)
主引用文献The inhibition mechanism of the SUR2A-containing K ATP channel by a regulatory helix.
Nat Commun, 14, 2023
7EB2
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Cryo-EM structure of human GABA(B) receptor-Gi protein complex
分子名称: (3S)-5,7-ditert-butyl-3-oxidanyl-3-(trifluoromethyl)-1-benzofuran-2-one, Gamma-aminobutyric acid type B receptor subunit 1, Gamma-aminobutyric acid type B receptor subunit 2, ...
著者Shen, C, Mao, C, Xu, C, Jin, N, Zhang, H, Shen, D, Shen, Q, Wang, X, Hou, T, Rondard, P, Chen, Z, Pin, J, Zhang, Y, Liu, J.
登録日2021-03-08
公開日2021-05-05
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structural basis of GABA B receptor-G i protein coupling.
Nature, 594, 2021
1H72
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CRYSTAL STRUCTURE OF HOMOSERINE KINASE COMPLEXED WITH HSE
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, HOMOSERINE KINASE, L-HOMOSERINE, ...
著者Krishna, S.S, Zhou, T, Daugherty, M, Osterman, A.L, Zhang, H.
登録日2001-07-02
公開日2001-09-13
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural Basis for the Catalysis and Substrate Specificity of Homoserine Kinase
Biochemistry, 40, 2001
1H73
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CRYSTAL STRUCTURE OF HOMOSERINE KINASE COMPLEXED WITH THREONINE
分子名称: HOMOSERINE KINASE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, THREONINE
著者Krishna, S.S, Zhou, T, Daugherty, M, Osterman, A.L, Zhang, H.
登録日2001-07-02
公開日2001-09-13
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Basis for the Catalysis and Substrate Specificity of Homoserine Kinase
Biochemistry, 40, 2001
4TVP
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Crystal Structure of the HIV-1 BG505 SOSIP.664 Env Trimer Ectodomain, Comprising Atomic-Level Definition of Pre-Fusion gp120 and gp41, in Complex with Human Antibodies PGT122 and 35O22
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22 Heavy chain, ...
著者Pancera, M, Zhou, T, Kwong, P.D.
登録日2014-06-27
公開日2014-10-08
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure and immune recognition of trimeric pre-fusion HIV-1 Env.
Nature, 514, 2014
6MX8
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Crystal structure of anaplastic lymphoma kinase (ALK) bound by Brigatinib
分子名称: 5-chloro-N~4~-[2-(dimethylphosphoryl)phenyl]-N~2~-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine, ALK tyrosine kinase receptor
著者Dougan, D.R, Zhou, T.
登録日2018-10-30
公開日2018-12-12
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Discovery of Brigatinib (AP26113), a Phosphine Oxide-Containing, Potent, Orally Active Inhibitor of Anaplastic Lymphoma Kinase.
J. Med. Chem., 59, 2016
5M3B
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BU of 5m3b by Molmil
Structure of cobinamide-bound BtuF mutant W66L, the periplasmic vitamin B12 binding protein in E.coli
分子名称: COB(II)INAMIDE, CYANIDE ION, GLYCEROL, ...
著者Mireku, S.A, Ruetz, M, Zhou, T, Korkhov, V.M, Kraeutler, B, Locher, K.P.
登録日2016-10-14
公開日2017-03-01
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Conformational Change of a Tryptophan Residue in BtuF Facilitates Binding and Transport of Cobinamide by the Vitamin B12 Transporter BtuCD-F.
Sci Rep, 7, 2017
5FYJ
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Crystal Structure at 3.4 A Resolution of Fully Glycosylated HIV-1 Clade G X1193.c1 SOSIP.664 Prefusion Env Trimer in Complex with Broadly Neutralizing Antibodies PGT122, 35O22 and VRC01
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Stewart-Jones, G.B.E, Zhou, T, Thomas, P.V, Kwong, P.D.
登録日2016-03-08
公開日2016-04-27
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (3.11 Å)
主引用文献Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B and G
Cell(Cambridge,Mass.), 165, 2016
5FYK
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Crystal Structure at 3.7 A Resolution of Fully Glycosylated HIV-1 Clade B JR-FL SOSIP.664 Prefusion Env Trimer in Complex with Broadly Neutralizing Antibodies PGT122, 35O22 and VRC01
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22, ...
著者Stewart-Jones, G.B.E, Zhou, T, Thomas, P.V, Kwong, P.D.
登録日2016-03-08
公開日2016-04-27
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.107 Å)
主引用文献Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B and G
Cell(Cambridge,Mass.), 165, 2016
5M2Q
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Structure of cobinamide-bound BtuF mutant W66F, the periplasmic vitamin B12 binding protein in E.coli
分子名称: COB(II)INAMIDE, CYANIDE ION, GLYCEROL, ...
著者Mireku, S.A, Ruetz, M, Zhou, T, Korkhov, V.M, Kraeutler, B, Locher, K.P.
登録日2016-10-13
公開日2017-03-01
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Conformational Change of a Tryptophan Residue in BtuF Facilitates Binding and Transport of Cobinamide by the Vitamin B12 Transporter BtuCD-F.
Sci Rep, 7, 2017
5M29
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Structure of cobinamide-bound BtuF, the periplasmic vitamin B12 binding protein in E.coli
分子名称: COB(II)INAMIDE, CYANIDE ION, GLYCEROL, ...
著者Mireku, S.A, Ruetz, M, Zhou, T, Korkhov, V.M, Kraeutler, B, Locher, K.P.
登録日2016-10-12
公開日2017-02-08
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Conformational Change of a Tryptophan Residue in BtuF Facilitates Binding and Transport of Cobinamide by the Vitamin B12 Transporter BtuCD-F.
Sci Rep, 7, 2017
5FYL
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Crystal Structure at 3.7 A Resolution of Fully Glycosylated HIV-1 Clade A BG505 SOSIP.664 Prefusion Env Trimer in Complex with Broadly Neutralizing Antibodies PGT122 and 35O22
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 35O22 ANTIBODY FAB HEAVY CHAIN, ...
著者Stewart-Jones, G.B.E, Zhou, T, Thomas, P.V, Kwong, P.D.
登録日2016-03-08
公開日2016-04-27
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B and G
Cell(Cambridge,Mass.), 165, 2016
4JPW
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Crystal structure of broadly and potently neutralizing antibody 12a21 in complex with hiv-1 strain 93th057 gp120 mutant
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HEAVY CHAIN OF ANTIBODY 12A21, ...
著者Acharya, P, Luongo, T, Zhou, T, Kwong, P.D.
登録日2013-03-19
公開日2013-04-17
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.904 Å)
主引用文献Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization.
Cell(Cambridge,Mass.), 153, 2013
5M34
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Structure of cobinamide-bound BtuF mutant W66Y, the periplasmic vitamin B12 binding protein in E.coli
分子名称: COB(II)INAMIDE, CYANIDE ION, GLYCEROL, ...
著者Mireku, S.A, Ruetz, M, Zhou, T, Korkhov, V.M, Kraeutler, B, Locher, K.P.
登録日2016-10-14
公開日2017-03-01
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Conformational Change of a Tryptophan Residue in BtuF Facilitates Binding and Transport of Cobinamide by the Vitamin B12 Transporter BtuCD-F.
Sci Rep, 7, 2017
4JHW
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Crystal Structure of Respiratory Syncytial Virus Fusion Glycoprotein Stabilized in the Prefusion Conformation by Human Antibody D25
分子名称: D25 antigen-binding fragment heavy chain, D25 light chain, Fusion glycoprotein F0
著者Mclellan, J.S, Chen, M, Leung, S, Graepel, K.W, Du, X, Yang, Y, Zhou, T, Baxa, U, Yasuda, E, Beaumont, T, Kumar, A, Modjarrad, K, Zheng, Z, Zhao, M, Xia, N, Kwong, P.D, Graham, B.S.
登録日2013-03-05
公開日2013-05-01
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Structure of RSV fusion glycoprotein trimer bound to a prefusion-specific neutralizing antibody.
Science, 340, 2013
4JHA
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Crystal Structure of RSV-Neutralizing Human Antibody D25
分子名称: D25 antigen-binding fragment heavy chain, D25 light chain
著者Mclellan, J.S, Chen, M, Leung, S, Graepel, K.W, Du, X, Yang, Y, Zhou, T, Baxa, U, Yasuda, E, Beaumont, T, Kumar, A, Modjarrad, K, Zheng, Z, Zhao, M, Xia, N, Kwong, P.D, Graham, B.S.
登録日2013-03-04
公開日2013-05-01
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structure of RSV fusion glycoprotein trimer bound to a prefusion-specific neutralizing antibody.
Science, 340, 2013
5V7J
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BU of 5v7j by Molmil
Crystal Structure at 3.7 A Resolution of Glycosylated HIV-1 Clade A BG505 SOSIP.664 Prefusion Env Trimer with Four Glycans (N197, N276, N362, and N462) removed in Complex with Neutralizing Antibodies 3H+109L and 35O22.
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody 35O22 Fab heavy chain, ...
著者Stewart-Jones, G.B.E, Zhou, T, Kwong, P.D.
登録日2017-03-20
公開日2017-06-21
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.907 Å)
主引用文献Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation.
Cell Rep, 19, 2017
5JOE
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Crystal structure of I81 from titin
分子名称: 1,2-ETHANEDIOL, ISOPROPYL ALCOHOL, Titin
著者Fleming, J, Zhou, T, Bogomolovas, J, Labeit, S, Mayans, O.
登録日2016-05-02
公開日2016-08-17
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex.
Febs Lett., 590, 2016
5F9W
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Crystal structure of broadly neutralizing VH1-46 germline-derived CD4-binding site-directed antibody CH235 in complex with HIV-1 clade A/E 93TH057 gp120
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of CH235-lineage antibody CH235, Light chain of CH235-lineage antibody CH235, ...
著者Chen, L, Zhou, T, Kwong, P.D.
登録日2015-12-10
公開日2016-03-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.8911 Å)
主引用文献Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody.
Cell, 165, 2016
5I8E
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Crystal Structure of Broadly Neutralizing HIV-1 Fusion Peptide-Targeting Antibody VRC34.01 Fab
分子名称: VRC34.01 Fab heavy chain, VRC34.01 Fab light chain, ZINC ION
著者Xu, K, Zhou, T, Liu, K, Kwong, P.D.
登録日2016-02-18
公開日2016-05-25
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.655 Å)
主引用文献Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody.
Science, 352, 2016
3R0M
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Crystal structure of anti-HIV llama VHH antibody A12
分子名称: Llama VHH A12, SULFATE ION
著者Chen, L, McLellan, J.S, Kwon, Y.D, Schmidt, S, Wu, X, Zhou, T, Yang, Y, Zhang, B, Forsman, A, Weiss, R.A, Verrips, T, Mascola, J, Kwong, P.D.
登録日2011-03-08
公開日2012-03-14
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Single-Headed Immunoglobulins Efficiently Penetrate CD4-Binding Site and Effectively Neutralize HIV-1
To be Published

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