6Q6R
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![BU of 6q6r by Molmil](/molmil-images/mine/6q6r) | Recognition of different base tetrads by RHAU: X-ray crystal structure of G4 recognition motif bound to the 3-end tetrad of a DNA G-quadruplex | Descriptor: | ATP-dependent DNA/RNA helicase DHX36, POTASSIUM ION, Parallel stranded DNA G-quadruplex | Authors: | Heddi, B, Cheong, V.V, Schmitt, E, Mechulam, Y, Phan, A.T. | Deposit date: | 2018-12-11 | Release date: | 2019-10-16 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Recognition of different base tetrads by RHAU (DHX36): X-ray crystal structure of the G4 recognition motif bound to the 3'-end tetrad of a DNA G-quadruplex. J.Struct.Biol., 209, 2020
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2N21
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![BU of 2n21 by Molmil](/molmil-images/mine/2n21) | Solution structure of complex between DNA G-quadruplex and G-quadruplex recognition domain of RHAU | Descriptor: | ATP-dependent RNA helicase DHX36, DNA (5'-D(*TP*TP*GP*GP*GP*TP*GP*GP*GP*TP*GP*GP*GP*TP*GP*GP*GP*T)-3') | Authors: | Heddi, B, Cheong, V.V, Martadinata, H, Phan, A.T. | Deposit date: | 2015-04-25 | Release date: | 2015-07-29 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Insights into G-quadruplex specific recognition by the DEAH-box helicase RHAU: Solution structure of a peptide-quadruplex complex. Proc.Natl.Acad.Sci.USA, 112, 2015
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2LD8
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![BU of 2ld8 by Molmil](/molmil-images/mine/2ld8) | |
2N16
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![BU of 2n16 by Molmil](/molmil-images/mine/2n16) | |
2N60
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![BU of 2n60 by Molmil](/molmil-images/mine/2n60) | G-quadruplexes with (4n-1) guanines in the G-tetrad core: formation of a G-triad water complex and implication for small-molecule binding | Descriptor: | DNA (5'-D(*TP*TP*GP*TP*GP*TP*GP*GP*GP*TP*GP*GP*GP*TP*GP*GP*GP*T)-3') | Authors: | Heddi, B, Martin-Pintado, N, Serimbetov, Z, Kari, T.M, Phan, A.T. | Deposit date: | 2015-08-08 | Release date: | 2016-06-01 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | G-quadruplexes with (4n - 1) guanines in the G-tetrad core: formation of a G-triadwater complex and implication for small-molecule binding Nucleic Acids Res., 44, 2016
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6K3X
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![BU of 6k3x by Molmil](/molmil-images/mine/6k3x) | |
2LPW
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![BU of 2lpw by Molmil](/molmil-images/mine/2lpw) | human CEB25 minisatellite G-quadruplex | Descriptor: | DNA (26-MER) | Authors: | Amrane, S, Adrian, M, Heddi, B, Serero, A, Nicolas, A, Mergny, J.L, Phan, A.T. | Deposit date: | 2012-02-20 | Release date: | 2012-03-07 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Formation of Pearl-Necklace Monomorphic G-Quadruplexes in the Human CEB25 Minisatellite. J.Am.Chem.Soc., 134, 2012
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6FQ2
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![BU of 6fq2 by Molmil](/molmil-images/mine/6fq2) | Structure of minimal sequence for left -handed G-quadruplex formation | Descriptor: | DNA (5'-D(*GP*TP*GP*GP*TP*GP*GP*TP*GP*GP*TP*G)-3'), POTASSIUM ION | Authors: | Schmitt, E, Mechulam, Y, Phan, A.T, Heddi, B, Bakalar, B. | Deposit date: | 2018-02-13 | Release date: | 2018-12-05 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | A Minimal Sequence for Left-Handed G-Quadruplex Formation. Angew. Chem. Int. Ed. Engl., 58, 2019
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6GZ6
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![BU of 6gz6 by Molmil](/molmil-images/mine/6gz6) | Structure of a left-handed G-quadruplex | Descriptor: | DNA (27-MER), POTASSIUM ION | Authors: | Bakalar, B, Heddi, B, Schmitt, E, Mechulam, Y, Phan, A.T. | Deposit date: | 2018-07-03 | Release date: | 2019-04-24 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.006 Å) | Cite: | A Minimal Sequence for Left-Handed G-Quadruplex Formation. Angew.Chem.Int.Ed.Engl., 58, 2019
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8IPF
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![BU of 8ipf by Molmil](/molmil-images/mine/8ipf) | |
6H1K
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![BU of 6h1k by Molmil](/molmil-images/mine/6h1k) | The major G-quadruplex form of HIV-1 LTR | Descriptor: | DNA (28-MER) | Authors: | Phan, A.T, Heddi, B, Butovskaya, E, Bakalar, B, Richter, S.N. | Deposit date: | 2018-07-11 | Release date: | 2018-10-17 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Major G-Quadruplex Form of HIV-1 LTR Reveals a (3 + 1) Folding Topology Containing a Stem-Loop. J. Am. Chem. Soc., 140, 2018
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8IPP
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![BU of 8ipp by Molmil](/molmil-images/mine/8ipp) | Crystal structure of the complex between an ankyrin and a parallel G-quadruplex | Descriptor: | 93del-T12, DARPin protein 2E4, MAGNESIUM ION, ... | Authors: | Ngo, K.H, Liew, C.W, Heddi, B, Phan, A.T. | Deposit date: | 2023-03-14 | Release date: | 2024-07-31 | Method: | X-RAY DIFFRACTION (2.007 Å) | Cite: | Structural Basis for Parallel G-Quadruplex Recognition by an Ankyrin Protein. J.Am.Chem.Soc., 146, 2024
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6K3Y
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![BU of 6k3y by Molmil](/molmil-images/mine/6k3y) | G-quadruplex complex with cyclic dinucleotide 3'-3' cGAMP | Descriptor: | 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, DNA (5'-D(*TP*TP*GP*GP*TP*GP*GP*GP*TP*GP*GP*GP*TP*GP*GP*GP*T)-3') | Authors: | Winnerdy, F.R, Heddi, B, Phan, A.T. | Deposit date: | 2019-05-22 | Release date: | 2020-01-15 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution Structures of a G-Quadruplex Bound to Linear- and Cyclic-Dinucleotides. J.Am.Chem.Soc., 141, 2019
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2N4Y
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![BU of 2n4y by Molmil](/molmil-images/mine/2n4y) | Structure and possible function of a G-quadruplex in the long terminal repeat of the proviral HIV-1 genome | Descriptor: | DNA_(5'-D(*CP*TP*GP*GP*GP*CP*GP*GP*GP*AP*CP*TP*GP*GP*GP*GP*AP*GP*TP*GP*GP*T)-3') | Authors: | DeNicola, B, Lech, C.J, Heddi, B, Regmi, S, Frasson, I, Perrone, R, Richter, S.N, Phan, A.T. | Deposit date: | 2015-07-02 | Release date: | 2016-06-29 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structure and possible function of a G-quadruplex in the long terminal repeat of the proviral HIV-1 genome. Nucleic Acids Res., 44, 2016
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2LE6
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![BU of 2le6 by Molmil](/molmil-images/mine/2le6) | Structure of a dimeric all-parallel-stranded G-quadruplex stacked via the 5'-to-5' interface | Descriptor: | DNA (5'-D(*GP*IP*GP*TP*GP*GP*GP*TP*GP*GP*GP*TP*GP*GP*GP*T)-3') | Authors: | Do, N.Q, Lim, K.W, Teo, M.H, Heddi, B, Phan, A.T. | Deposit date: | 2011-06-10 | Release date: | 2011-08-31 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Stacking of G-quadruplexes: NMR structure of a G-rich oligonucleotide with potential anti-HIV and anticancer activity Nucleic Acids Res., 2011
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2MB3
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![BU of 2mb3 by Molmil](/molmil-images/mine/2mb3) | Solution structure of an intramolecular (3+1) human telomeric G-quadruplex bound to a telomestatin derivative | Descriptor: | (12S,27S)-12,27-bis(4-aminobutyl)-4,30-dimethyl-3,7,14,18,22,29-hexaoxa-11,26,31,32,33,34,35,36-octaazaheptacyclo[26.2. 1.1~2,5~.1~6,9~.1~13,16~.1~17,20~.1~21,24~]hexatriaconta-1(30),2(36),4,6(35),8,13(34),15,17(33),19,21(32),23,28(31)-dode caene-10,25-dione, DNA_(5'-D(*TP*TP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*A)-3') | Authors: | Chung, W.J, Heddi, B, Tera, M, Iida, K, Nagasawa, K, Phan, A.T. | Deposit date: | 2013-07-24 | Release date: | 2013-08-28 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution structure of an intramolecular (3 + 1) human telomeric g-quadruplex bound to a telomestatin derivative. J.Am.Chem.Soc., 135, 2013
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2MB4
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![BU of 2mb4 by Molmil](/molmil-images/mine/2mb4) | Solution structure of a stacked dimeric G-quadruplex formed by a segment of the human CEB1 minisatellite | Descriptor: | DNA_(5'-D(*AP*GP*GP*GP*GP*GP*GP*AP*GP*GP*GP*AP*GP*GP*GP*TP*GP*G)-3') | Authors: | Adrian, M, Ang, D.J, Lech, C, Heddi, B, Nicolas, A, Phan, A.T. | Deposit date: | 2013-07-25 | Release date: | 2014-05-28 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structure and Conformational Dynamics of a Stacked Dimeric G-Quadruplex Formed by the Human CEB1 Minisatellite. J.Am.Chem.Soc., 136, 2014
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2MGN
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![BU of 2mgn by Molmil](/molmil-images/mine/2mgn) | Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC3 | Descriptor: | 5'-D(*TP*GP*AP*GP*GP*GP*TP*GP*GP*TP*GP*AP*GP*GP*GP*TP*GP*GP*GP*GP*AP*AP*GP*G)-3', N2,N9-bis(1-methylquinolin-3-yl)-1,10-phenanthroline-2,9-dicarboxamide | Authors: | Chung, W.J, Heddi, B, Hamon, F, Teulade-Fichou, M.P, Phan, A.T. | Deposit date: | 2013-11-01 | Release date: | 2014-01-22 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution Structure of a G-quadruplex Bound to the Bisquinolinium Compound Phen-DC3. Angew.Chem.Int.Ed.Engl., 53, 2014
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2MB2
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![BU of 2mb2 by Molmil](/molmil-images/mine/2mb2) | parallel-stranded G-quadruplex in DNA poly-G stretches | Descriptor: | DNA_(5'-D(*TP*TP*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*T)-3') | Authors: | Sengar, A, Heddi, B, Phan, A.T. | Deposit date: | 2013-07-24 | Release date: | 2014-12-03 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Formation of g-quadruplexes in poly-g sequences: structure of a propeller-type parallel-stranded g-quadruplex formed by a g15 stretch. Biochemistry, 53, 2014
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2MAY
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![BU of 2may by Molmil](/molmil-images/mine/2may) | |
2MBJ
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![BU of 2mbj by Molmil](/molmil-images/mine/2mbj) | Structure of an antiparallel (2+2) G-quadruplex formed by human telomeric repeats in Na+ solution (with G22-to-BrG substitution) | Descriptor: | DNA_(27-MER) | Authors: | Lim, K.W, Ng, V.C.M, Martin-Pintado, N, Heddi, B, Phan, A.T. | Deposit date: | 2013-08-02 | Release date: | 2013-09-18 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structure of the human telomere in Na+ solution: an antiparallel (2+2) G-quadruplex scaffold reveals additional diversity. Nucleic Acids Res., 41, 2013
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2MWZ
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![BU of 2mwz by Molmil](/molmil-images/mine/2mwz) | |
2MS9
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![BU of 2ms9 by Molmil](/molmil-images/mine/2ms9) | Solution structure of a G-quadruplex | Descriptor: | DNA (28-MER) | Authors: | Chung, W.J, Heddi, B, Schmitt, E, Lim, K.W, Mechulam, Y, Phan, A.T. | Deposit date: | 2014-07-25 | Release date: | 2015-02-18 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structure of a left-handed DNA G-quadruplex Proc.Natl.Acad.Sci.USA, 2015
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2N3M
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![BU of 2n3m by Molmil](/molmil-images/mine/2n3m) | |