6QGX
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![BU of 6qgx by Molmil](/molmil-images/mine/6qgx) | Crystal structure of E.coli BamA beta-barrel in complex with nanobody F7 | 分子名称: | (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, NanoF7, Outer membrane protein assembly factor BamA | 著者 | Hartmann, J.-B, Kaur, H, Jakob, R.P, Zahn, M, Zimmermann, I, Seeger, M, Maier, T, Hiller, S. | 登録日 | 2019-01-14 | 公開日 | 2019-06-26 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Identification of conformation-selective nanobodies against the membrane protein insertase BamA by an integrated structural biology approach. J.Biomol.Nmr, 73, 2019
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6QGW
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![BU of 6qgw by Molmil](/molmil-images/mine/6qgw) | Crystal structure of E.coli BamA beta-barrel in complex with nanobody E6 | 分子名称: | (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, NanoE6, Outer membrane protein assembly factor BamA | 著者 | Hartmann, J.-B, Kaur, H, Jakob, R.P, Zahn, M, Zimmermann, I, Seeger, M, Maier, T, Hiller, S. | 登録日 | 2019-01-14 | 公開日 | 2019-06-26 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.938 Å) | 主引用文献 | Identification of conformation-selective nanobodies against the membrane protein insertase BamA by an integrated structural biology approach. J.Biomol.Nmr, 73, 2019
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6QGY
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![BU of 6qgy by Molmil](/molmil-images/mine/6qgy) | Crystal structure of E.coli BamA beta-barrel in complex with nanobody B12 | 分子名称: | (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, NanoB12, Outer membrane protein assembly factor BamA | 著者 | Hartmann, J.-B, Kaur, H, Jakob, R.P, Zahn, M, Zimmermann, I, Seeger, M, Maier, T, Hiller, S. | 登録日 | 2019-01-14 | 公開日 | 2019-06-26 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.509 Å) | 主引用文献 | Identification of conformation-selective nanobodies against the membrane protein insertase BamA by an integrated structural biology approach. J.Biomol.Nmr, 73, 2019
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5M05
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![BU of 5m05 by Molmil](/molmil-images/mine/5m05) | Chicken smooth muscle myosin motor domain co-crystallized with the specific CK-571 inhibitor, MgADP form | 分子名称: | 4-{[(2-chloro-3-fluorobenzyl)carbamoyl](methyl)amino}-3,4-dideoxy-5-O-(isoquinolin-3-ylcarbamoyl)-D-erythro-pentitol, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Sirigu, S, Hartman, J, Houdusse, A. | 登録日 | 2016-10-03 | 公開日 | 2016-11-16 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.675 Å) | 主引用文献 | Highly selective inhibition of myosin motors provides the basis of potential therapeutic application. Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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5T45
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![BU of 5t45 by Molmil](/molmil-images/mine/5t45) | Chicken smooth muscle myosin motor domain co-crystallized with the specific CK-571 inhibitor, MgADP.BeFx form | 分子名称: | 4-{[(2-chloro-3-fluorobenzyl)carbamoyl](methyl)amino}-3,4-dideoxy-5-O-(isoquinolin-3-ylcarbamoyl)-D-erythro-pentitol, ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ... | 著者 | Sirigu, S, Planelles-Herrero, V.J, Hartman, J, Houdusse, A. | 登録日 | 2016-08-29 | 公開日 | 2016-11-16 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Highly selective inhibition of myosin motors provides the basis of potential therapeutic application. Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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5N69
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![BU of 5n69 by Molmil](/molmil-images/mine/5n69) | Cardiac muscle myosin S1 fragment in the pre-powerstroke state co-crystallized with the activator Omecamtiv Mecarbil | 分子名称: | 3,3',3''-phosphanetriyltripropanoic acid, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ... | 著者 | Planelles-Herrero, V.J, Hartman, J.J, Robert-Paganin, J, Malik, F.I, Houdusse, A. | 登録日 | 2017-02-14 | 公開日 | 2017-08-16 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil. Nat Commun, 8, 2017
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5N6A
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![BU of 5n6a by Molmil](/molmil-images/mine/5n6a) | Cardiac muscle myosin motor domain in the pre-powerstroke state | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | 著者 | Planelles-Herrero, V.J, Hartman, J.J, Robert-Paganin, J, Malik, F.I, Houdusse, A. | 登録日 | 2017-02-14 | 公開日 | 2017-08-09 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil. Nat Commun, 8, 2017
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7KAA
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![BU of 7kaa by Molmil](/molmil-images/mine/7kaa) | NMR solution structures of tirasemtiv drug bound to a fast skeletal troponin C-troponin I complex | 分子名称: | 6-ethynyl-1-(pentan-3-yl)-1H-imidazo[4,5-b]pyrazin-2-ol, CALCIUM ION, Troponin C, ... | 著者 | Mercier, P, Li, M.X, Hartman, J.J, Sykes, B.D. | 登録日 | 2020-09-30 | 公開日 | 2021-03-24 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural Basis of Tirasemtiv Activation of Fast Skeletal Muscle. J.Med.Chem., 64, 2021
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3LRE
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![BU of 3lre by Molmil](/molmil-images/mine/3lre) | |
3DXK
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![BU of 3dxk by Molmil](/molmil-images/mine/3dxk) | Structure of Bos Taurus Arp2/3 Complex with Bound Inhibitor CK0944636 | 分子名称: | Actin-related protein 2, Actin-related protein 2/3 complex subunit 1B, Actin-related protein 2/3 complex subunit 2, ... | 著者 | Nolen, B.J, Tomasevic, N, Russell, A, Pierce, D.W, Jia, Z, Hartman, J, Sakowicz, R, Pollard, T.D. | 登録日 | 2008-07-24 | 公開日 | 2009-07-28 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Characterization of two classes of small molecule inhibitors of Arp2/3 complex Nature, 460, 2009
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3DXM
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![BU of 3dxm by Molmil](/molmil-images/mine/3dxm) | Structure of Bos taurus Arp2/3 Complex with Bound Inhibitor CK0993548 | 分子名称: | (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one, Actin-related protein 2, Actin-related protein 2/3 complex subunit 1B, ... | 著者 | Nolen, B.J, Tomasevic, N, Russell, A, Pierce, D.W, Jia, Z, Hartman, J, Sakowicz, R, Pollard, T.D. | 登録日 | 2008-07-24 | 公開日 | 2009-07-28 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Characterization of two classes of small molecule inhibitors of Arp2/3 complex Nature, 460, 2009
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7SWI
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![BU of 7swi by Molmil](/molmil-images/mine/7swi) | cTnC-TnI chimera complexed with A2 | 分子名称: | 4-(3-cyano-3-methylazetidine-1-carbonyl)-N-[(3R,4S)-7-fluoro-4-hydroxy-6-methyl-3,4-dihydro-2H-1-benzopyran-3-yl]-5-methyl-1H-pyrrole-2-sulfonamide, Troponin C, slow skeletal and cardiac muscles,Troponin I, ... | 著者 | Poppe, L, Hartman, J.J, Romero, A, Reagan, J.D. | 登録日 | 2021-11-19 | 公開日 | 2022-04-06 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural and Thermodynamic Model for the Activation of Cardiac Troponin. Biochemistry, 61, 2022
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7SUP
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![BU of 7sup by Molmil](/molmil-images/mine/7sup) | NMR structure of cTnC-TnI chimera bound to calcium and A1 | 分子名称: | 4-(3-cyano-3-methylazetidine-1-carbonyl)-N-[(3S)-7-fluoro-6-methyl-3,4-dihydro-2H-1-benzopyran-3-yl]-5-methyl-1H-pyrrole-2-sulfonamide, CALCIUM ION, Troponin C, ... | 著者 | Poppe, L, Hartman, J.J, Romero, A, Reagan, J.D. | 登録日 | 2021-11-17 | 公開日 | 2022-04-06 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural and Thermodynamic Model for the Activation of Cardiac Troponin. Biochemistry, 61, 2022
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7SVC
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![BU of 7svc by Molmil](/molmil-images/mine/7svc) | NMR structure of cTnC-TnI chimera bound to calcium and A2 | 分子名称: | 4-(3-cyano-3-methylazetidine-1-carbonyl)-N-[(3R,4S)-7-fluoro-4-hydroxy-6-methyl-3,4-dihydro-2H-1-benzopyran-3-yl]-5-methyl-1H-pyrrole-2-sulfonamide, CALCIUM ION, Troponin C, ... | 著者 | Poppe, L, Hartman, J.J, Romero, A, Reagan, J.D. | 登録日 | 2021-11-18 | 公開日 | 2022-04-06 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural and Thermodynamic Model for the Activation of Cardiac Troponin. Biochemistry, 61, 2022
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7SWG
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![BU of 7swg by Molmil](/molmil-images/mine/7swg) | cTnC-TnI chimera complexed with A1 | 分子名称: | 4-(3-cyano-3-methylazetidine-1-carbonyl)-N-[(3S)-7-fluoro-6-methyl-3,4-dihydro-2H-1-benzopyran-3-yl]-5-methyl-1H-pyrrole-2-sulfonamide, Troponin C, slow skeletal and cardiac muscles,Troponin I, ... | 著者 | Poppe, L, Hartman, J.J, Romero, A, Reagan, J.D. | 登録日 | 2021-11-19 | 公開日 | 2022-04-06 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural and Thermodynamic Model for the Activation of Cardiac Troponin. Biochemistry, 61, 2022
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7SXD
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![BU of 7sxd by Molmil](/molmil-images/mine/7sxd) | NMR solution structure TnC-TnI chimera | 分子名称: | Troponin C, slow skeletal and cardiac muscles,Troponin I, cardiac muscle chimera | 著者 | Poppe, L, Hartman, J.J, Romero, A, Reagan, J.D. | 登録日 | 2021-11-22 | 公開日 | 2022-04-06 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural and Thermodynamic Model for the Activation of Cardiac Troponin. Biochemistry, 61, 2022
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7SXC
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![BU of 7sxc by Molmil](/molmil-images/mine/7sxc) | cTnC-TnI chimera complexed with calcium | 分子名称: | CALCIUM ION, Troponin C, slow skeletal and cardiac muscles,Troponin I, ... | 著者 | Poppe, L, Hartman, J.J, Romero, A, Reagan, J.D. | 登録日 | 2021-11-22 | 公開日 | 2022-04-06 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural and Thermodynamic Model for the Activation of Cardiac Troponin. Biochemistry, 61, 2022
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4TW8
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![BU of 4tw8 by Molmil](/molmil-images/mine/4tw8) | The Fk1-Fk2 domains of FKBP52 in complex with iFit-FL | 分子名称: | 2-(5-{[({3-[(1R)-1-[({(2S)-1-[(2S)-2-[(1S)-cyclohex-2-en-1-yl]-2-(3,4,5-trimethoxyphenyl)acetyl]piperidin-2-yl}carbonyl)oxy]-3-(3,4-dimethoxyphenyl)propyl]phenoxy}acetyl)amino]methyl}-6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid, Peptidyl-prolyl cis-trans isomerase FKBP4 | 著者 | Gaali, S, Kirschner, A, Cuboni, S, Hartmann, J, Kozany, C, Balsevich, G, Namendorf, C, Fernandez-Vizarra, P, Almeida, O.F.X, Ruehter, G, Uhr, M, Schmidt, M.V, Touma, C, Bracher, A, Hausch, F. | 登録日 | 2014-06-30 | 公開日 | 2014-11-26 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.003 Å) | 主引用文献 | Selective inhibitors of the FK506-binding protein 51 by induced fit. Nat.Chem.Biol., 11, 2015
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6FSU
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![BU of 6fsu by Molmil](/molmil-images/mine/6fsu) | |
4TW6
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![BU of 4tw6 by Molmil](/molmil-images/mine/4tw6) | The Fk1 domain of FKBP51 in complex with iFit1 | 分子名称: | (3-{(1R)-3-(3,4-dimethoxyphenyl)-1-[({(2S)-1-[(2S)-2-(3,4,5-trimethoxyphenyl)pent-4-enoyl]piperidin-2-yl}carbonyl)oxy]propyl}phenoxy)acetic acid, GLYCEROL, Peptidyl-prolyl cis-trans isomerase FKBP5, ... | 著者 | Gaali, S, Kirschner, A, Cuboni, S, Hartmann, J, Kozany, C, Balsevich, G, Namendorf, C, Fernandez-Vizarra, P, Almeida, O.F.X, Ruehter, G, Uhr, M, Schmidt, M.V, Touma, C, Bracher, A, Hausch, F. | 登録日 | 2014-06-30 | 公開日 | 2014-11-26 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Selective inhibitors of the FK506-binding protein 51 by induced fit. Nat.Chem.Biol., 11, 2015
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4TW7
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![BU of 4tw7 by Molmil](/molmil-images/mine/4tw7) | The Fk1 domain of FKBP51 in complex with iFit4 | 分子名称: | (1R)-3-(3,4-dimethoxyphenyl)-1-{3-[2-(morpholin-4-yl)ethoxy]phenyl}propyl (2S)-1-[(2S)-2-[(1S)-cyclohex-2-en-1-yl]-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carboxylate, Peptidyl-prolyl cis-trans isomerase FKBP5 | 著者 | Gaali, S, Kirschner, A, Cuboni, S, Hartmann, J, Kozany, C, Balsevich, G, Namendorf, C, Fernandez-Vizarra, P, Almeida, O.F.X, Ruehter, G, Uhr, M, Schmidt, M.V, Touma, C, Bracher, A, Hausch, F. | 登録日 | 2014-06-30 | 公開日 | 2014-11-26 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Selective inhibitors of the FK506-binding protein 51 by induced fit. Nat.Chem.Biol., 11, 2015
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