7SWG

cTnC-TnI chimera complexed with A1

Summary for 7SWG

• Entry DOI: 10.2210/pdb7swg/pdb
• NMR Information: BMRB: 30965
• Descriptor: Troponin C, slow skeletal and cardiac muscles,Troponin I, cardiac muscle chimera, 4-(3-cyano-3-methylazetidine-1-carbonyl)-N-[(3S)-7-fluoro-6-methyl-3,4-dihydro-2H-1-benzopyran-3-yl]-5-methyl-1H-pyrrole-2-sulfonamide (2 entities in total)
• Functional Keywords: cardiac troponin, calcium sensitizer, metal binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 14668.62

Authors

Poppe, L.,Hartman, J.J.,Romero, A.,Reagan, J.D. (deposition date: 2021-11-19, release date: 2022-04-06, Last modification date: 2023-06-14)

• Primary citation: Poppe, L.,Hartman, J.J.,Romero, A.,Reagan, J.D.; Structural and Thermodynamic Model for the Activation of Cardiac Troponin.; Biochemistry, 61:741-748, 2022; PubMed: 35349258; DOI: 10.1021/acs.biochem.2c00084

Experimental method

SOLUTION NMR