5N69
Cardiac muscle myosin S1 fragment in the pre-powerstroke state co-crystallized with the activator Omecamtiv Mecarbil
Summary for 5N69
| Entry DOI | 10.2210/pdb5n69/pdb |
| Descriptor | Myosin-7, Myosin light chain 3, ADENOSINE-5'-DIPHOSPHATE, ... (9 entities in total) |
| Functional Keywords | myosin, cardiac, omecamtiv mecarbil, ck-452, cytokinetics, pre-powerstroke, motor protein |
| Biological source | Bos taurus (Bovine) More |
| Cellular location | Cytoplasm, myofibril : Q9BE39 |
| Total number of polymer chains | 4 |
| Total formula weight | 238093.81 |
| Authors | Planelles-Herrero, V.J.,Hartman, J.J.,Robert-Paganin, J.,Malik, F.I.,Houdusse, A. (deposition date: 2017-02-14, release date: 2017-08-16, Last modification date: 2024-01-17) |
| Primary citation | Planelles-Herrero, V.J.,Hartman, J.J.,Robert-Paganin, J.,Malik, F.I.,Houdusse, A. Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil. Nat Commun, 8:190-190, 2017 Cited by PubMed: 28775348DOI: 10.1038/s41467-017-00176-5 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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