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PDB: 362 results

7EI2
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BU of 7ei2 by Molmil
Structure of human NNMT in complex with macrocyclic peptide 8
Descriptor: Nicotinamide N-methyltransferase, macrocyclic peptide 8
Authors:Hayashi, K, Mikamiyama, H, Uehara, S, Yamamoto, S, Cary, D, Nishikawa, J, Ueda, T, Ozasa, H, Mihara, K, Yoshimura, N, Kawai, T, Ono, T, Yamamoto, S, Fumoto, M.
Deposit date:2021-03-30
Release date:2022-03-30
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Macrocyclic Peptides as a Novel Class of NNMT Inhibitors: A SAR Study Aimed at Inhibitory Activity in the Cell.
Acs Med.Chem.Lett., 12, 2021
7EHZ
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Structure of human NNMT in complex with macrocyclic peptide 2
Descriptor: Nicotinamide N-methyltransferase, macrocyclic peptide 2
Authors:Hayashi, K, Mikamiyama, H, Uehara, S, Yamamoto, S, Cary, D, Nishikawa, J, Ueda, T, Ozasa, H, Mihara, K, Yoshimura, N, Kawai, T, Ono, T, Yamamoto, S, Fumoto, M.
Deposit date:2021-03-30
Release date:2021-12-15
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Macrocyclic Peptides as a Novel Class of NNMT Inhibitors: A SAR Study Aimed at Inhibitory Activity in the Cell.
Acs Med.Chem.Lett., 12, 2021
7EGU
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Structure of human NNMT in complex with macrocyclic peptide X
Descriptor: Nicotinamide N-methyltransferase, macrocyclic peptide X
Authors:Hayashi, K, Mikamiyama, H, Uehara, S, Yamamoto, S, Cary, D, Nishikawa, J, Ueda, T, Ozasa, H, Mihara, K, Yoshimura, N, Kawai, T, Ono, T, Yamamoto, S, Fumoto, M.
Deposit date:2021-03-26
Release date:2021-12-15
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Macrocyclic Peptides as a Novel Class of NNMT Inhibitors: A SAR Study Aimed at Inhibitory Activity in the Cell.
Acs Med.Chem.Lett., 12, 2021
8SEH
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BU of 8seh by Molmil
PHF Tau from Down Syndrome
Descriptor: Microtubule-associated protein tau
Authors:Hoq, M.R, Bharath, S.R, Jiang, W, Vago, F.S.
Deposit date:2023-04-10
Release date:2024-04-03
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Cryo-EM structures of amyloid-beta and tau filaments in Down syndrome.
Nat.Struct.Mol.Biol., 31, 2024
8SEK
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BU of 8sek by Molmil
Type IIIa beta-amyloid 40 Filaments from Down syndrome
Descriptor: Type IIIb beta-amyloid 40 Filament
Authors:Hoq, M.R, Vago, F.S, Bharath, S.R, Jiang, W.
Deposit date:2023-04-10
Release date:2024-04-03
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Cryo-EM structures of amyloid-beta and tau filaments in Down syndrome.
Nat.Struct.Mol.Biol., 31, 2024
8SEJ
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BU of 8sej by Molmil
Type I beta-amyloid 42 Filaments from Down syndrome
Descriptor: Amyloid-beta protein 42
Authors:Hoq, M.R, Bharath, S.R, Vago, F.S, Jiang, W.
Deposit date:2023-04-10
Release date:2024-04-03
Last modified:2024-06-26
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:Cryo-EM structures of amyloid-beta and tau filaments in Down syndrome.
Nat.Struct.Mol.Biol., 31, 2024
7BV7
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BU of 7bv7 by Molmil
INTS3 complexed with INTS6
Descriptor: Integrator complex subunit 3, Integrator complex subunit 6
Authors:Jia, Y, Bharath, S.R, Song, H.
Deposit date:2020-04-09
Release date:2021-07-14
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the INTS3/INTS6 complex reveals the functional importance of INTS3 dimerization in DSB repair.
Cell Discov, 7, 2021
5L8H
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BU of 5l8h by Molmil
Structure of USP46-UbVME
Descriptor: Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 46, ZINC ION
Authors:Clerici, M, Sixma, T, Dharadhar, S.
Deposit date:2016-06-07
Release date:2016-09-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzyme.
J.Struct.Biol., 196, 2016
6M01
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BU of 6m01 by Molmil
The structure of HitB-HitD complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, N-[2-(acetylamino)ethyl]-N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide, ...
Authors:Miyanaga, A, Kurihara, S, Kudo, F, Eguchi, T.
Deposit date:2020-02-19
Release date:2020-07-08
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Characterization of Complex of Adenylation Domain and Carrier Protein by Using Pantetheine Cross-Linking Probe.
Acs Chem.Biol., 15, 2020
5JXE
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BU of 5jxe by Molmil
Human PD-1 ectodomain complexed with Pembrolizumab Fab
Descriptor: Pembrolizumab Fab heavy chain, Pembrolizumab Fab light chain, Programmed cell death protein 1
Authors:Na, Z, Bharath, S.R, Song, H.
Deposit date:2016-05-13
Release date:2016-08-10
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for blocking PD-1-mediated immune suppression by therapeutic antibody pembrolizumab.
Cell Res., 27, 2017
6LP1
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BU of 6lp1 by Molmil
Crystal structure of acetate:succinate CoA transferase (ASCT) from Trypanosoma brucei.
Descriptor: CALCIUM ION, GLYCEROL, Succinyl-CoA:3-ketoacid-coenzyme A transferase
Authors:Mochizuki, K, Inaoka, D.K, Shiba, T, Fukuda, K, Kurasawa, H, Mazet, M, Millerioux, Y, Bringaud, F, Boshart, M, Balogun, E.O, Harada, S, Hirayama, K, Kita, K.
Deposit date:2020-01-08
Release date:2020-10-07
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:The ASCT/SCS cycle fuels mitochondrial ATP and acetate production in Trypanosoma brucei.
Biochim Biophys Acta Bioenerg, 1861, 2020
6XN4
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BU of 6xn4 by Molmil
Structure of the Lactococcus lactis Csm CTR_3:2 CRISPR-Cas Complex
Descriptor: CRISPR-associated protein Cas10, CRISPR-associated protein Csm2, CRISPR-associated protein Csm3, ...
Authors:Rai, J, Sridhara, S, Li, H.
Deposit date:2020-07-02
Release date:2022-01-12
Last modified:2022-04-13
Method:ELECTRON MICROSCOPY (3.35 Å)
Cite:Structural and biochemical characterization of in vivo assembled Lactococcus lactis CRISPR-Csm complex.
Commun Biol, 5, 2022
6XN5
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BU of 6xn5 by Molmil
Structure of the Lactococcus lactis Csm Apo- CRISPR-Cas Complex
Descriptor: CRISPR-associated protein Cas10, CRISPR-associated protein Csm3, CRISPR-associated protein Csm4, ...
Authors:Rai, J, Sridhara, S, Li, H.
Deposit date:2020-07-02
Release date:2022-01-12
Last modified:2022-04-13
Method:ELECTRON MICROSCOPY (2.97 Å)
Cite:Structural and biochemical characterization of in vivo assembled Lactococcus lactis CRISPR-Csm complex.
Commun Biol, 5, 2022
6XN3
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BU of 6xn3 by Molmil
Structure of the Lactococcus lactis Csm CTR_4:3 CRISPR-Cas Complex
Descriptor: CRISPR-associated protein Cas10, CRISPR-associated protein Csm2, CRISPR-associated protein Csm3, ...
Authors:Rai, J, Sridhara, S, Li, H.
Deposit date:2020-07-02
Release date:2022-01-12
Last modified:2022-04-13
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural and biochemical characterization of in vivo assembled Lactococcus lactis CRISPR-Csm complex.
Commun Biol, 5, 2022
6XN7
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BU of 6xn7 by Molmil
Structure of the Lactococcus lactis Csm NTR CRISPR-Cas Complex
Descriptor: CRISPR-associated protein Cas10, CRISPR-associated protein Csm2, CRISPR-associated protein Csm3, ...
Authors:Rai, J, Sridhara, S, Li, H.
Deposit date:2020-07-02
Release date:2022-01-12
Last modified:2022-04-13
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:Structural and biochemical characterization of in vivo assembled Lactococcus lactis CRISPR-Csm complex.
Commun Biol, 5, 2022
7JG1
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BU of 7jg1 by Molmil
Dimeric Immunoglobin A (dIgA)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Igh protein, ...
Authors:Kumar Bharathkar, S, Parker, B.P, Malyutin, A.G, Stadtmueller, B.M.
Deposit date:2020-07-18
Release date:2020-11-11
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:The structures of Secretory and dimeric Immunoglobulin A.
Elife, 9, 2020
7XOH
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BU of 7xoh by Molmil
Cystathionine beta-synthase of Mycobacterium tuberculosis in the presence of S-adenosylmethionine.
Descriptor: PYRIDOXAL-5'-PHOSPHATE, Putative cystathionine beta-synthase Rv1077
Authors:Bandyopadhyay, P, Pramanick, I, Biswas, R, Sabarinath, P.S, Sreedharan, S, Singh, S, Rajmani, R, Laxman, S, Dutta, S, Singh, A.
Deposit date:2022-05-01
Release date:2022-05-25
Last modified:2022-12-07
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:S-Adenosylmethionine-responsive cystathionine beta-synthase modulates sulfur metabolism and redox balance in Mycobacterium tuberculosis.
Sci Adv, 8, 2022
7XOY
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BU of 7xoy by Molmil
Cystathionine beta-synthase of Mycobacterium tuberculosis in the presence of S-adenosylmethionine and serine.
Descriptor: Putative cystathionine beta-synthase Rv1077, [3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-SERINE
Authors:Bandyopadhyay, P, Pramanick, I, Biswas, R, Sabarinath, P.S, Sreedharan, S, Singh, S, Rajmani, R, Laxman, S, Dutta, S, Singh, A.
Deposit date:2022-05-01
Release date:2022-05-25
Last modified:2024-07-03
Method:ELECTRON MICROSCOPY (4.25 Å)
Cite:S-Adenosylmethionine-responsive cystathionine beta-synthase modulates sulfur metabolism and redox balance in Mycobacterium tuberculosis.
Sci Adv, 8, 2022
7JG2
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BU of 7jg2 by Molmil
Secretory Immunoglobin A (SIgA)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Igh protein, ...
Authors:Kumar Bharathkar, S, Parker, B.P, Malyutin, A.G, Stadtmueller, B.M.
Deposit date:2020-07-18
Release date:2020-11-11
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:The structures of Secretory and dimeric Immunoglobulin A.
Elife, 9, 2020
7WMT
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BU of 7wmt by Molmil
Crystal structure of small molecule 13 bound to human Nicotinamide N-methyltransferase
Descriptor: Nicotinamide N-methyltransferase, [(2~{R},4~{S})-4-[2-(aminomethyl)imidazol-1-yl]-2-[1-[(4-chlorophenyl)methyl]-5-methyl-indol-2-yl]pyrrolidin-1-yl]-(1~{H}-pyrrolo[2,3-b]pyridin-5-yl)methanone
Authors:Yoshida, S, Uehara, S, Kondo, N, Takahashi, Y, Yamamoto, S, Kameda, A, Kawagoe, S, Inoue, N, Yamada, M, Yoshimura, N, Tachibana, Y.
Deposit date:2022-01-17
Release date:2022-08-31
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Peptide-to-Small Molecule: A Pharmacophore-Guided Small Molecule Lead Generation Strategy from High-Affinity Macrocyclic Peptides.
J.Med.Chem., 65, 2022
7XNZ
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Native cystathionine beta-synthase of Mycobacterium tuberculosis.
Descriptor: PYRIDOXAL-5'-PHOSPHATE, Putative cystathionine beta-synthase Rv1077
Authors:Bandyopadhyay, P, Pramanick, I, Biswas, R, Sabarinath, P.S, Sreedharan, S, Singh, S, Rajmani, R, Laxman, S, Dutta, S, Singh, A.
Deposit date:2022-04-30
Release date:2022-05-25
Last modified:2022-12-07
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:S-Adenosylmethionine-responsive cystathionine beta-synthase modulates sulfur metabolism and redox balance in Mycobacterium tuberculosis.
Sci Adv, 8, 2022
7WMC
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BU of 7wmc by Molmil
Crystal structure of macrocyclic peptide 1 bound to human Nicotinamide N-methyltransferase
Descriptor: Nicotinamide N-methyltransferase, Peptide1
Authors:Yoshida, S, Uehara, S, Kondo, N, Takahashi, Y, Yamamoto, S, Kameda, A, Kawagoe, S, Inoue, N, Yamada, M, Yoshimura, N, Tachibana, Y.
Deposit date:2022-01-14
Release date:2022-08-31
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Peptide-to-Small Molecule: A Pharmacophore-Guided Small Molecule Lead Generation Strategy from High-Affinity Macrocyclic Peptides.
J.Med.Chem., 65, 2022
7X17
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BU of 7x17 by Molmil
Structure of Pseudomonas NRPS protein, AmbB-TC bound to Ppant-L-Ala
Descriptor: AMB antimetabolite synthase AmbB, S-[2-[3-[[(2S)-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (2R)-2-azanylpropanethioate
Authors:ChuYuanKee, M, Bharath, S.R, Song, H.
Deposit date:2022-02-23
Release date:2022-07-13
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural insights into the substrate-bound condensation domains of non-ribosomal peptide synthetase AmbB.
Sci Rep, 12, 2022
6M1B
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BU of 6m1b by Molmil
A new V27M variant of beta 2 microglobulin induced amyloidosis in a patient with long-term hemodialysis
Descriptor: Beta-2-microglobulin, CALCIUM ION, GLYCEROL, ...
Authors:So, M, Nakahara, S, Nakaniwa, T, Tanaka, H, Kurisu, G, Goto, Y.
Deposit date:2020-02-25
Release date:2021-01-06
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Dialysis-related amyloidosis associated with a novel beta 2 -microglobulin variant.
Amyloid, 28, 2021
7X0F
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Structure of Pseudomonas NRPS protein, AmbB-TC bound to Ppant
Descriptor: 4'-PHOSPHOPANTETHEINE, AMB antimetabolite synthase AmbB
Authors:ChuYuanKee, M, Bharath, S.R, Song, H.
Deposit date:2022-02-22
Release date:2022-06-15
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural insights into the substrate-bound condensation domains of non-ribosomal peptide synthetase AmbB.
Sci Rep, 12, 2022

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數據於2024-07-31公開中

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