7EHZ

Structure of human NNMT in complex with macrocyclic peptide 2

Summary for 7EHZ

• Entry DOI: 10.2210/pdb7ehz/pdb
• Descriptor: Nicotinamide N-methyltransferase, macrocyclic peptide 2 (3 entities in total)
• Functional Keywords: nicotinamide n-methyltransferase, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 30094.56

Authors

Hayashi, K.,Mikamiyama, H.,Uehara, S.,Yamamoto, S.,Cary, D.,Nishikawa, J.,Ueda, T.,Ozasa, H.,Mihara, K.,Yoshimura, N.,Kawai, T.,Ono, T.,Yamamoto, S.,Fumoto, M. (deposition date: 2021-03-30, release date: 2021-12-15, Last modification date: 2023-11-29)

• Primary citation: Hayashi, K.,Uehara, S.,Yamamoto, S.,Cary, D.R.,Nishikawa, J.,Ueda, T.,Ozasa, H.,Mihara, K.,Yoshimura, N.,Kawai, T.,Ono, T.,Yamamoto, S.,Fumoto, M.,Mikamiyama, H.; Macrocyclic Peptides as a Novel Class of NNMT Inhibitors: A SAR Study Aimed at Inhibitory Activity in the Cell.; Acs Med.Chem.Lett., 12:1093-1101, 2021; PubMed: 34267879; DOI: 10.1021/acsmedchemlett.1c00134

Experimental method

X-RAY DIFFRACTION (2.5 Å)