7EHZ
Structure of human NNMT in complex with macrocyclic peptide 2
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006769 | biological_process | nicotinamide metabolic process |
A | 0008112 | molecular_function | nicotinamide N-methyltransferase activity |
A | 0008168 | molecular_function | methyltransferase activity |
A | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
A | 0009410 | biological_process | response to xenobiotic stimulus |
A | 0010243 | biological_process | response to organonitrogen compound |
A | 0030760 | molecular_function | pyridine N-methyltransferase activity |
A | 0031100 | biological_process | animal organ regeneration |
A | 0032259 | biological_process | methylation |
A | 0034356 | biological_process | NAD biosynthesis via nicotinamide riboside salvage pathway |
A | 0045722 | biological_process | positive regulation of gluconeogenesis |
A | 0090312 | biological_process | positive regulation of protein deacetylation |
Functional Information from PROSITE/UniProt
site_id | PS01100 |
Number of Residues | 17 |
Details | NNMT_PNMT_TEMT NNMT/PNMT/TEMT family of methyltransferases signature. LIDIGSGPTIYQLLSAC |
Chain | Residue | Details |
A | LEU59-CYS75 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:21823666, ECO:0000269|Ref.12 |
Chain | Residue | Details |
A | ASN90 | |
A | ASP142 | |
A | THR163 | |
A | TYR20 | |
A | TYR25 | |
A | GLY63 | |
A | TYR69 | |
A | ASP85 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:21823666 |
Chain | Residue | Details |
A | ASP197 | |
A | SER213 |
site_id | SWS_FT_FI3 |
Number of Residues | 3 |
Details | MOD_RES: Citrulline; alternate => ECO:0000269|PubMed:30044909 |
Chain | Residue | Details |
A | ARG181 | |
A | ARG18 | |
A | ARG132 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | LYS39 |