5JXE

Human PD-1 ectodomain complexed with Pembrolizumab Fab

Summary for 5JXE

• Entry DOI: 10.2210/pdb5jxe/pdb
• Descriptor: Programmed cell death protein 1, Pembrolizumab Fab light chain, Pembrolizumab Fab heavy chain, ... (4 entities in total)
• Functional Keywords: human pd-1 pembrolizumab fab, immune system
• Biological source: Homo sapiens (Human); More
• Cellular location: Membrane; Single-pass type I membrane protein: Q15116
• Total number of polymer chains: 6
• Total formula weight: 120328.11

Authors

Na, Z.,Bharath, S.R.,Song, H. (deposition date: 2016-05-13, release date: 2016-08-10, Last modification date: 2023-11-08)

• Primary citation: Na, Z.,Yeo, S.P.,Bharath, S.R.,Bowler, M.W.,Balijkcij, E.,Wang, C.I.,Song, H.; Structural basis for blocking PD-1-mediated immune suppression by therapeutic antibody pembrolizumab.; Cell Res., 27:147-150, 2017; PubMed: 27325296; DOI: 10.1038/cr.2016.77

Experimental method

X-RAY DIFFRACTION (2.9 Å)