7OQE
| Saccharomyces cerevisiae spliceosomal pre-A complex (delta BS-A ACT1) | Descriptor: | 56 kDa U1 small nuclear ribonucleoprotein component, ACT1 pre-mRNA (delta BS-A), Cold sensitive U2 snRNA suppressor 1, ... | Authors: | Zhang, Z, Rigo, N, Dybkov, O, Fourmann, J, Will, C.L, Kumar, V, Urlaub, H, Stark, H, Luehrmann, R. | Deposit date: | 2021-06-03 | Release date: | 2021-08-11 | Last modified: | 2021-09-29 | Method: | ELECTRON MICROSCOPY (5.9 Å) | Cite: | Structural insights into how Prp5 proofreads the pre-mRNA branch site. Nature, 596, 2021
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7OQB
| The U2 part of Saccharomyces cerevisiae spliceosomal pre-A complex (delta BS-A ACT1) | Descriptor: | ACT1 pre-mRNA (delta-BS-A), Cold sensitive U2 snRNA suppressor 1, Pre-mRNA-processing ATP-dependent RNA helicase PRP5, ... | Authors: | Zhang, Z, Rigo, N, Dybkov, O, Fourmann, J, Will, C.L, Kumar, V, Urlaub, H, Stark, H, Luehrmann, R. | Deposit date: | 2021-06-03 | Release date: | 2021-08-11 | Last modified: | 2021-09-22 | Method: | ELECTRON MICROSCOPY (9 Å) | Cite: | Structural insights into how Prp5 proofreads the pre-mRNA branch site. Nature, 596, 2021
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8BDP
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7OQC
| The U1 part of Saccharomyces cerevisiae spliceosomal pre-A complex (delta BS-A ACT1) | Descriptor: | 56 kDa U1 small nuclear ribonucleoprotein component, ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A), Pre-mRNA-processing factor 39, ... | Authors: | Zhang, Z, Rigo, N, Dybkov, O, Fourmann, J, Will, C.L, Kumar, V, Urlaub, H, Stark, H, Luehrmann, R. | Deposit date: | 2021-06-03 | Release date: | 2021-08-11 | Last modified: | 2021-09-29 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural insights into how Prp5 proofreads the pre-mRNA branch site. Nature, 596, 2021
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6Y6I
| lipopolysaccharide outer core galactosyltransferase WaaB and UDP complex | Descriptor: | Lipopolysaccharide 1,6-galactosyltransferase, URIDINE-5'-DIPHOSPHATE | Authors: | Zhang, Z.Y, Ashworth, G, Wang, Z.S, Zhu, X.F, Dong, C.J. | Deposit date: | 2020-02-26 | Release date: | 2021-03-31 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Structural insights into the lipopolysaccharide outer core galactosyltransferase WaaB To Be Published
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6Y6G
| lipopolysaccharide outer core galactosyltransferase WaaB apo form | Descriptor: | Lipopolysaccharide 1,6-galactosyltransferase | Authors: | Zhang, Z.Y, Ashworth, G, Wang, Z.S, Zhu, X.F, Dong, C.J. | Deposit date: | 2020-02-26 | Release date: | 2021-03-31 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Structural insights into the lipopolysaccharide outer core galactosyltransferase WaaB To Be Published
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4RDD
| Co-crystal structure of SHP2 in complex with a Cefsulodin derivative | Descriptor: | 1-({(2R)-4-carboxy-2-[(R)-carboxy{[(2R)-2-phenyl-2-sulfoacetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazin-5-yl}methyl)pyridinium, Tyrosine-protein phosphatase non-receptor type 11 | Authors: | Zhang, Z.Y, Yu, Z.H, He, R, Zhang, R.Y. | Deposit date: | 2014-09-18 | Release date: | 2015-07-01 | Last modified: | 2015-12-16 | Method: | X-RAY DIFFRACTION (1.601 Å) | Cite: | Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors. ACS Med Chem Lett, 6, 2015
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4RL5
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8GUN
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8GUO
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8GXN
| The crystal structure of CsFAOMT2 in complex with SAH | Descriptor: | MAGNESIUM ION, S-ADENOSYL-L-HOMOCYSTEINE, caffeyl-CoA-O-methyltransferase | Authors: | Zhang, Z.M, Zhou, Y.E, Huang, H.S. | Deposit date: | 2022-09-20 | Release date: | 2023-09-20 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.34 Å) | Cite: | Characterization of two O-methyltransferases involved in the biosynthesis of O-methylated catechins in tea plant. Nat Commun, 14, 2023
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8GXO
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4WXX
| The crystal structure of human DNMT1(351-1600) | Descriptor: | DNA (cytosine-5)-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION | Authors: | Zhang, Z.M, Song, J. | Deposit date: | 2014-11-14 | Release date: | 2015-07-15 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.622 Å) | Cite: | Crystal Structure of Human DNA Methyltransferase 1. J.Mol.Biol., 427, 2015
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8QO9
| Cryo-EM structure of a human spliceosomal B complex protomer | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, MINX pre-mRNA, Microfibrillar-associated protein 1, ... | Authors: | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Urlaub, H, Stark, H, Luehrmann, R. | Deposit date: | 2023-09-28 | Release date: | 2024-01-24 | Method: | ELECTRON MICROSCOPY (5.29 Å) | Cite: | New insights into the functions of B complex proteins revealed by cryo-EM of dimerized
spliceosomes To Be Published
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8Q7N
| cryo-EM structure of the human spliceosomal B complex protomer (tri-snRNP core region) | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, MINX pre-mRNA, Microfibrillar-associated protein 1, ... | Authors: | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Urlaub, H, Stark, H, Luehrmann, R. | Deposit date: | 2023-08-16 | Release date: | 2024-01-24 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | New insights into the functions of B complex proteins revealed by cryo-EM of dimerized spliceosomes To Be Published
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8R09
| Cryo-EM structure of the cross-exon pre-B+5'ss+ATPgammaS complex | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, NHP2-like protein 1, ... | Authors: | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | Deposit date: | 2023-10-31 | Release date: | 2024-05-22 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 2024
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8R0A
| Cryo-EM structure of the cross-exon pre-B+5'ss complex | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, NHP2-like protein 1, ... | Authors: | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | Deposit date: | 2023-10-31 | Release date: | 2024-05-22 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (5.8 Å) | Cite: | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 2024
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8QPA
| Cryo-EM Structure of Pre-B+5'ssLNG Complex (core part) | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | Deposit date: | 2023-10-01 | Release date: | 2024-05-22 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 2024
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8R0B
| Cryo-EM structure of the cross-exon pre-B+ATP complex | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, NHP2-like protein 1, ... | Authors: | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | Deposit date: | 2023-10-31 | Release date: | 2024-05-22 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 2024
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8RM5
| Cryo-EM structure of the cross-exon pre-B+5'ssLNG+ATPyS complex | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'SS oligo, NHP2-like protein 1, ... | Authors: | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | Deposit date: | 2024-01-05 | Release date: | 2024-05-22 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (6.9 Å) | Cite: | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 2024
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8CX5
| Crystal Structure of small molecule alpha,beta-ketoamide 4 covalently bound to K-Ras(G12R) | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, MAGNESIUM ION, ... | Authors: | Zhang, Z, Morstein, J, Ecker, A, Guiley, K.Z, Shokat, K.M. | Deposit date: | 2022-05-19 | Release date: | 2022-08-31 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Chemoselective Covalent Modification of K-Ras(G12R) with a Small Molecule Electrophile. J.Am.Chem.Soc., 144, 2022
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8DMU
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8DMS
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8DMQ
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8QOZ
| Cryo-EM Structure of Pre-B+5'ss+ATPgammaS Complex (core part) | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss RNA oligo, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | Deposit date: | 2023-09-29 | Release date: | 2024-05-22 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 2024
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