7X9C
 
 | | Cryo-EM structure of neuropeptide Y Y4 receptor in complex with PP and Gi | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Tang, T, Han, S, Zhao, Q, Wu, B. | | 登録日 | 2022-03-15 | | 公開日 | 2022-05-18 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Receptor-specific recognition of NPY peptides revealed by structures of NPY receptors.
Sci Adv, 8, 2022
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7X9A
 | | Cryo-EM structure of neuropeptide Y Y1 receptor in complex with NPY and Gi | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Tang, T, Han, S, Zhao, Q, Wu, B. | | 登録日 | 2022-03-15 | | 公開日 | 2022-05-18 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Receptor-specific recognition of NPY peptides revealed by structures of NPY receptors.
Sci Adv, 8, 2022
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7DDZ
 | | The Crystal Structure of Human Neuropeptide Y Y2 Receptor with JNJ-31020028 | | 分子名称: | FLAVIN MONONUCLEOTIDE, Human Neuropeptide Y Y2 Receptor fusion protein, ~{N}-[4-[4-[(1~{S})-2-(diethylamino)-2-oxidanylidene-1-phenyl-ethyl]piperazin-1-yl]-3-fluoranyl-phenyl]-2-pyridin-3-yl-benzamide | | 著者 | Tang, T, Han, S, Zhao, Q, Wu, B. | | 登録日 | 2020-10-30 | | 公開日 | 2021-01-27 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural basis for ligand recognition of the neuropeptide Y Y 2 receptor.
Nat Commun, 12, 2021
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7XK8
 | | Cryo-EM structure of the Neuromedin U receptor 2 (NMUR2) in complex with G Protein and its endogeneous Peptide-Agonist NMU25 | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Zhao, W, Wenru, Z, Mu, W, Minmin, L, Shutian, C, Tingting, T, Gisela, S, Holger, W, Albert, B, Cuiying, Y, Xiaojing, C, Han, S, Wu, B, Zhao, Q. | | 登録日 | 2022-04-19 | | 公開日 | 2023-02-22 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Ligand recognition and activation of neuromedin U receptor 2.
Nat Commun, 13, 2022
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7EPC
 | | Cryo-EM structure of inactive mGlu7 homodimer | | 分子名称: | Isoform 3 of Metabotropic glutamate receptor 7 | | 著者 | Du, J, Wang, D, Fan, H, Tai, L, Lin, S, Han, S, Sun, F, Wu, B, Zhao, Q. | | 登録日 | 2021-04-26 | | 公開日 | 2021-06-23 | | 最終更新日 | 2021-07-07 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structures of human mGlu2 and mGlu7 homo- and heterodimers.
Nature, 594, 2021
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7EPA
 | | Cryo-EM structure of inactive mGlu2 homodimer | | 分子名称: | Metabotropic glutamate receptor 2 | | 著者 | Du, J, Wang, D, Fan, H, Tai, L, Lin, S, Han, S, Sun, F, Wu, B, Zhao, Q. | | 登録日 | 2021-04-26 | | 公開日 | 2021-06-23 | | 最終更新日 | 2021-07-07 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structures of human mGlu2 and mGlu7 homo- and heterodimers.
Nature, 594, 2021
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7EPB
 | | Cryo-EM structure of LY354740-bound mGlu2 homodimer | | 分子名称: | (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid, Anti-RON nanobody, Metabotropic glutamate receptor 2 | | 著者 | Du, J, Wang, D, Fan, H, Tai, L, Lin, S, Han, S, Sun, F, Wu, B, Zhao, Q. | | 登録日 | 2021-04-26 | | 公開日 | 2021-06-23 | | 最終更新日 | 2021-07-07 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structures of human mGlu2 and mGlu7 homo- and heterodimers.
Nature, 594, 2021
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7EPF
 | | Crystal structure of mGlu2 bound to NAM597 | | 分子名称: | (8~{R})-4-[2,4-bis(fluoranyl)phenyl]-8-methyl-7-[(2-methylpyrazol-3-yl)methyl]-6,8-dihydro-5~{H}-1,7-naphthyridine-2-carboxamide, FLAVIN MONONUCLEOTIDE, Metabotropic glutamate receptor 2 | | 著者 | Du, J, Wang, D, Lin, S, Han, S, Wu, B, Zhao, Q. | | 登録日 | 2021-04-26 | | 公開日 | 2021-06-23 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structures of human mGlu2 and mGlu7 homo- and heterodimers.
Nature, 594, 2021
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7EPD
 | | Cryo-EM structure of inactive mGlu2-7 heterodimer | | 分子名称: | Isoform 3 of Metabotropic glutamate receptor 7, Metabotropic glutamate receptor 2,Peptidylprolyl isomerase | | 著者 | Du, J, Wang, D, Fan, H, Tai, L, Lin, S, Han, S, Sun, F, Wu, B, Zhao, Q. | | 登録日 | 2021-04-26 | | 公開日 | 2021-06-23 | | 最終更新日 | 2021-07-07 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structures of human mGlu2 and mGlu7 homo- and heterodimers.
Nature, 594, 2021
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7EPE
 | | Crystal structure of mGlu2 bound to NAM563 | | 分子名称: | 4-(1-methylpyrazol-4-yl)-7-[[(2~{S})-2-(trifluoromethyl)morpholin-4-yl]methyl]quinoline-2-carboxamide, FLAVIN MONONUCLEOTIDE, Metabotropic glutamate receptor 2 | | 著者 | Du, J, Wang, D, Lin, S, Han, S, Wu, B, Zhao, Q. | | 登録日 | 2021-04-26 | | 公開日 | 2021-06-23 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structures of human mGlu2 and mGlu7 homo- and heterodimers.
Nature, 594, 2021
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1ZPE
 | | Arginase I covalently modified with butylamine at Q19C | | 分子名称: | Arginase 1, MANGANESE (II) ION | | 著者 | Colleluori, D.M, Reczkowski, R.S, Emig, F.A, Cama, E, Cox, J.D, Scolnick, L.R, Compher, K, Jude, K, Han, S, Viola, R.E, Christianson, D.W, Ash, D.E. | | 登録日 | 2005-05-16 | | 公開日 | 2005-12-06 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Probing the role of the hyper-reactive histidine residue of arginase.
Arch.Biochem.Biophys., 444, 2005
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7D6C
 | | Crystal structure of CcmM N-terminal domain in complex with CcmN | | 分子名称: | Carbon dioxide concentrating mechanism protein CcmM, Carboxysome assembly protein CcmN | | 著者 | Sun, H, Cui, N, Han, S.J, Chen, Z.P, Xia, L.Y, Chen, Y, Jiang, Y.L, Zhou, C.Z. | | 登録日 | 2020-09-30 | | 公開日 | 2021-08-04 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | | 主引用文献 | Complex structure reveals CcmM and CcmN form a heterotrimeric adaptor in beta-carboxysome.
Protein Sci., 30, 2021
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4UCG
 | | NmeDAH7PS R126S variant | | 分子名称: | DI(HYDROXYETHYL)ETHER, MANGANESE (II) ION, PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, ... | | 著者 | Cross, P.J, Heyes, L.C, Zhang, S, Nazmi, A.R, Parker, E.J. | | 登録日 | 2014-12-03 | | 公開日 | 2016-01-13 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The Functional Unit of Neisseria Meningitidis 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase is Dimeric.
Plos One, 11, 2016
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8JYL
 | | Acyl-ACP Synthetase structure bound to C10-AMS | | 分子名称: | Acyl-acyl carrier protein synthetase, MAGNESIUM ION, [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl N-decanoylsulfamate | | 著者 | Huang, H, Chang, S, Huang, M, Zhang, H, Zhou, C, Zhang, X, Feng, Y. | | 登録日 | 2023-07-03 | | 公開日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (2.33 Å) | | 主引用文献 | Acyl-ACP Synthetase structure bound to C10-AMS
To Be Published
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1ZZL
 | | Crystal structure of P38 with triazolopyridine | | 分子名称: | 6-[4-(4-FLUOROPHENYL)-1,3-OXAZOL-5-YL]-3-ISOPROPYL[1,2,4]TRIAZOLO[4,3-A]PYRIDINE, Mitogen-activated protein kinase 14 | | 著者 | McClure, K.F, Han, S. | | 登録日 | 2005-06-14 | | 公開日 | 2005-09-13 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Theoretical and Experimental Design of Atypical Kinase Inhibitors: Application to p38 MAP Kinase.
J.Med.Chem., 48, 2005
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7WVV
 | | Cryo-EM structure of the human formyl peptide receptor 2 in complex with fMLFII and Gi2 | | 分子名称: | FME-LEU-PHE-ILE-ILE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | | 登録日 | 2022-02-11 | | 公開日 | 2022-04-13 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022
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7WVU
 | | Cryo-EM structure of the human formyl peptide receptor 1 in complex with fMLF and Gi1 | | 分子名称: | FME-LEU-PHE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | | 登録日 | 2022-02-11 | | 公開日 | 2022-04-13 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022
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7WVX
 | | Cryo-EM structure of the human formyl peptide receptor 2 in complex with fhumanin and Gi2 | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-2, ... | | 著者 | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | | 登録日 | 2022-02-11 | | 公開日 | 2022-04-13 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.
Nat Commun, 13, 2022
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7X9B
 | | Cryo-EM structure of neuropeptide Y Y2 receptor in complex with NPY and Gi | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Tang, T, Han, S, Zhao, Q, Wu, B. | | 登録日 | 2022-03-15 | | 公開日 | 2022-05-18 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Receptor-specific recognition of NPY peptides revealed by structures of NPY receptors.
Sci Adv, 8, 2022
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7XBW
 | | Cryo-EM structure of the human chemokine receptor CX3CR1 in complex with Gi1 | | 分子名称: | CHOLESTEROL, CX3C chemokine receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Lu, M, Zhao, W, Han, S, Zhu, Y, Wu, B, Zhao, Q. | | 登録日 | 2022-03-22 | | 公開日 | 2022-07-13 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Activation of the human chemokine receptor CX3CR1 regulated by cholesterol.
Sci Adv, 8, 2022
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7XBX
 | | Cryo-EM structure of the human chemokine receptor CX3CR1 in complex with CX3CL1 and Gi1 | | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Lu, M, Zhao, W, Han, S, Zhu, Y, Wu, B, Zhao, Q. | | 登録日 | 2022-03-22 | | 公開日 | 2022-07-13 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Activation of the human chemokine receptor CX3CR1 regulated by cholesterol.
Sci Adv, 8, 2022
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7XNA
 | | Crystal structure of somatostatin receptor 2 (SSTR2) with peptide antagonist CYN 154806 | | 分子名称: | CYN 154806, Somatostatin receptor type 2,Endo-1,4-beta-xylanase | | 著者 | Zhao, W, Han, S, Qiu, N, Feng, W, Lu, M, Yang, D, Wang, M.-W, Wu, B, Zhao, Q. | | 登録日 | 2022-04-28 | | 公開日 | 2022-08-03 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Structural insights into ligand recognition and selectivity of somatostatin receptors.
Cell Res., 32, 2022
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7XN9
 | | Crystal structure of SSTR2 and L-054,522 complex | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Somatostatin receptor type 2,Endo-1,4-beta-xylanase, tert-butyl (2S)-6-azanyl-2-[[(2R,3S)-3-(1H-indol-3-yl)-2-[[4-(2-oxidanylidene-3H-benzimidazol-1-yl)piperidin-1-yl]carbonylamino]butanoyl]amino]hexanoate | | 著者 | Zhao, W, Han, S, Qiu, N, Feng, W, Lu, M, Yang, D, Wang, M.-W, Wu, B, Zhao, Q. | | 登録日 | 2022-04-28 | | 公開日 | 2022-08-03 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural insights into ligand recognition and selectivity of somatostatin receptors.
Cell Res., 32, 2022
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8JYU
 | | Acyl-ACP Synthetase structure bound to Decanoyl-AMP | | 分子名称: | ADENOSINE MONOPHOSPHATE, Acyl-acyl carrier protein synthetase, DECANOIC ACID, ... | | 著者 | Huang, H, Chang, S, Huang, M, Zhang, H, Zhou, C, Zhang, X, Feng, Y. | | 登録日 | 2023-07-03 | | 公開日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (2.19 Å) | | 主引用文献 | Acyl-ACP Synthetase structure bound to Decanoyl-AMP
To Be Published
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1ZPG
 | | Arginase I covalently modified with propylamine at Q19C | | 分子名称: | Arginase 1, MANGANESE (II) ION | | 著者 | Colleluori, D.M, Reczkowski, R.S, Emig, F.A, Cama, E, Cox, J.D, Scolnick, L.R, Compher, K, Jude, K, Han, S, Viola, R.E, Christianson, D.W, Ash, D.E. | | 登録日 | 2005-05-16 | | 公開日 | 2005-12-06 | | 最終更新日 | 2021-10-20 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Probing the role of the hyper-reactive histidine residue of arginase.
Arch.Biochem.Biophys., 444, 2005
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