7LKI
 
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8Q71
 | | Crystal structure of SARS-CoV-2 main protease (MPro) in complex with the inhibitor GC-67 | | 分子名称: | (2~{S})-1-(3,4-dichlorophenyl)-4-(4-methoxypyridin-3-yl)carbonyl-~{N}-(thiophen-2-ylmethyl)piperazine-2-carboxamide, 3C-like proteinase nsp5 | | 著者 | Strater, N, Muller, C.E, Sylvester, K, Weisse, R.H, Useini, A, Gao, S, Song, L, Liu, Z, Zhan, P. | | 登録日 | 2023-08-15 | | 公開日 | 2023-12-06 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.322 Å) | | 主引用文献 | Design, Synthesis, and Biological Evaluation of Trisubstituted Piperazine Derivatives as Noncovalent Severe Acute Respiratory Syndrome Coronavirus 2 Main Protease Inhibitors with Improved Antiviral Activity and Favorable Druggability.
J.Med.Chem., 66, 2023
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7X0Y
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7X0X
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6CAJ
 | | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from Homo sapiens | | 分子名称: | 2-(4-chloranylphenoxy)-~{N}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide, Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, ... | | 著者 | Tsai, J.C, Miller-Vedam, L.E, Anand, A.A, Jaishankar, P, Nguyen, H.C, Renslo, A.R, Frost, A, Walter, P. | | 登録日 | 2018-01-31 | | 公開日 | 2018-04-11 | | 最終更新日 | 2019-11-20 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule.
Science, 359, 2018
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7FHR
 | | Crystal Structure of a Rieske Oxygenase from Cupriavidus metallidurans | | 分子名称: | 1,2-ETHANEDIOL, FE (II) ION, FE2/S2 (INORGANIC) CLUSTER, ... | | 著者 | Mahto, J.K, Dhankhar, P, Kumar, P. | | 登録日 | 2021-07-30 | | 公開日 | 2021-12-15 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | | 主引用文献 | Molecular insights into substrate recognition and catalysis by phthalate dioxygenase from Comamonas testosteroni.
J.Biol.Chem., 297, 2021
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3P4F
 | | Structural and biochemical insights into MLL1 core complex assembly and regulation. | | 分子名称: | Histone-lysine N-methyltransferase MLL, Retinoblastoma-binding protein 5, WD repeat-containing protein 5 | | 著者 | Avdic, V, Zhang, P, Lanouette, S, Groulx, A, Tremblay, V, Brunzelle, J.B, Couture, J.-F. | | 登録日 | 2010-10-06 | | 公開日 | 2010-12-08 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Structural and biochemical insights into MLL1 core complex assembly.
Structure, 19, 2011
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3NFI
 | | Crystal structure of tandem winged helix domain of RNA polymerase I subunit A49 | | 分子名称: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, DNA-directed RNA polymerase I subunit RPA49 | | 著者 | Geiger, S.R, Lorenzen, K, Schreieck, A, Hanecker, P, Kostrewa, D, Heck, A.J.R, Cramer, P. | | 登録日 | 2010-06-10 | | 公開日 | 2010-09-08 | | 最終更新日 | 2015-03-25 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | RNA Polymerase I Contains a TFIIF-Related DNA-Binding Subcomplex.
Mol.Cell, 39, 2010
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1K46
 | | Crystal Structure of the Type III Secretory Domain of Yersinia YopH Reveals a Domain-Swapped Dimer | | 分子名称: | PROTEIN-TYROSINE PHOSPHATASE YOPH | | 著者 | Smith, C.L, Khandelwal, P, Keliikuli, K, Zuiderweg, E.R.P, Saper, M.A. | | 登録日 | 2001-10-05 | | 公開日 | 2001-11-28 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structure of the type III secretion and substrate-binding domain of Yersinia YopH phosphatase.
Mol.Microbiol., 42, 2001
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2QTX
 | | Crystal structure of an Hfq-like protein from Methanococcus jannaschii | | 分子名称: | Uncharacterized protein MJ1435 | | 著者 | Nielsen, J.S, Boggild, A, Andersen, C.B.F, Nielsen, G, Boysen, A, Brodersen, D.E, Valentin-Hansen, P. | | 登録日 | 2007-08-03 | | 公開日 | 2007-11-06 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | An Hfq-like protein in archaea: Crystal structure and functional characterization of the Sm protein from Methanococcus jannaschii.
Rna, 13, 2007
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1LO6
 | | Human Kallikrein 6 (hK6) active form with benzamidine inhibitor at 1.56 A resolution | | 分子名称: | BENZAMIDINE, Kallikrein 6, MAGNESIUM ION | | 著者 | Bernett, M.J, Blaber, S.I, Scarisbrick, I.A, Dhanarajan, P, Thompson, S.M, Blaber, M. | | 登録日 | 2002-05-06 | | 公開日 | 2002-05-15 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | | 主引用文献 | Crystal structure and biochemical characterization of human kallikrein 6 reveals a
trypsin-like kallikrein is expressed in the central nervous system
To be Published
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3NFH
 | | Crystal structure of tandem winged helix domain of RNA polymerase I subunit A49 (P4) | | 分子名称: | DNA-directed RNA polymerase I subunit RPA49 | | 著者 | Geiger, S.R, Lorenzen, K, Schreieck, A, Hanecker, P, Kostrewa, D, Heck, A.J.R, Cramer, P. | | 登録日 | 2010-06-10 | | 公開日 | 2010-09-08 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | | 主引用文献 | RNA Polymerase I Contains a TFIIF-Related DNA-Binding Subcomplex.
Mol.Cell, 39, 2010
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7YZY
 | | pMMO structure from native membranes by cryoET and STA | | 分子名称: | Methane monooxygenase subunit C2, Particulate methane monooxygenase alpha subunit, Particulate methane monooxygenase beta subunit | | 著者 | Zhu, Y, Ni, T, Zhang, P. | | 登録日 | 2022-02-21 | | 公開日 | 2022-08-10 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | | 主引用文献 | Structure and activity of particulate methane monooxygenase arrays in methanotrophs.
Nat Commun, 13, 2022
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7ZC1
 | | Subtomogram averaging of Rubisco from Cyanobium carboxysome | | 分子名称: | Ribulose bisphosphate carboxylase large chain, Ribulose bisphosphate carboxylase, small subunit | | 著者 | Ni, T, Zhu, Y, Seaton-Burn, W, Zhang, P. | | 登録日 | 2022-03-25 | | 公開日 | 2022-07-06 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structure and assembly of cargo Rubisco in two native alpha-carboxysomes.
Nat Commun, 13, 2022
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1XRT
 | | The Crystal Structure of a Novel, Latent Dihydroorotase from Aquifex Aeolicus at 1.7 A Resolution | | 分子名称: | Dihydroorotase, ZINC ION | | 著者 | Martin, P.D, Purcarea, C, Zhang, P, Vaishnav, A, Sadecki, S, Guy-Evans, H.I, Evans, D.R, Edwards, B.F. | | 登録日 | 2004-10-15 | | 公開日 | 2005-07-05 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.609 Å) | | 主引用文献 | The crystal structure of a novel, latent dihydroorotase from Aquifex aeolicus at 1.7A resolution
J.Mol.Biol., 348, 2005
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7L7G
 | | Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from Homo sapiens (updated model of PDB ID: 6CAJ) | | 分子名称: | 2-(4-chloranylphenoxy)-~{N}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide, Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, ... | | 著者 | Tsai, J.C, Miller-Vedam, L.E, Anand, A, Jaishankar, P, Nguyen, H.C, Wang, L, Renslo, A.R, Frost, A, Walter, P. | | 登録日 | 2020-12-28 | | 公開日 | 2021-03-24 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | eIF2B conformation and assembly state regulates the integrated stress response.
Elife, 10, 2021
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1RZ4
 | | Crystal Structure of Human eIF3k | | 分子名称: | Eukaryotic translation initiation factor 3 subunit 11, SULFATE ION | | 著者 | Wei, Z, Zhang, P, Zhou, Z, Gong, W. | | 登録日 | 2003-12-23 | | 公開日 | 2004-09-21 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structure of human eIF3k, the first structure of eIF3 subunits
J.Biol.Chem., 279, 2004
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8A1S
 | | Structure of murine perforin-2 (Mpeg1) pore in twisted form | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage-expressed gene 1 protein | | 著者 | Yu, X, Ni, T, Zhang, P, Gilbert, R. | | 登録日 | 2022-06-02 | | 公開日 | 2022-07-20 | | 最終更新日 | 2023-10-18 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Cryo-EM structures of perforin-2 in isolation and assembled on a membrane suggest a mechanism for pore formation.
Embo J., 41, 2022
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8A1D
 | | Structure of murine perforin-2 (Mpeg1) pore in ring form | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, Macrophage-expressed gene 1 protein | | 著者 | Yu, X, Ni, T, Zhang, P, Gilbert, R. | | 登録日 | 2022-06-01 | | 公開日 | 2022-07-20 | | 最終更新日 | 2022-12-14 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Cryo-EM structures of perforin-2 in isolation and assembled on a membrane suggest a mechanism for pore formation.
Embo J., 41, 2022
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1NON
 | | PyrR, the regulator of the pyrimidine biosynthetic operon in Bacillus caldolyticus | | 分子名称: | PyrR bifunctional protein | | 著者 | Switzer, R.L, Chander, P, Smith, J.L, Halbig, K.M, Miller, J.K, Bonner, H.K, Grabner, G.K. | | 登録日 | 2003-01-16 | | 公開日 | 2004-05-25 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structure of the Nucleotide Complex of PyrR, the pyr Attenuation Protein from Bacillus caldolyticus, Suggests Dual Regulation by Pyrimidine and Purine Nucleotides
J.Bacteriol., 187, 2005
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3HJT
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4HZL
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5YIO
 | | NMR solution structure of subunit epsilon of the Mycobacterium tuberculosis F-ATP synthase | | 分子名称: | ATP synthase epsilon chain | | 著者 | Shin, J, Ragunathan, P, Sundararaman, L, Nartey, W, Manimekalai, M.S.S, Bogdanovic, N, Gruber, G. | | 登録日 | 2017-10-06 | | 公開日 | 2018-10-10 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The NMR solution structure of Mycobacterium tuberculosis F-ATP synthase subunit epsilon provides new insight into energy coupling inside the rotary engine.
FEBS J., 285, 2018
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1EDM
 | | EPIDERMAL GROWTH FACTOR-LIKE DOMAIN FROM HUMAN FACTOR IX | | 分子名称: | CALCIUM ION, FACTOR IX | | 著者 | Rao, Z, Handford, P, Mayhew, M, Knott, V, Brownlee, G.G, Stuart, D. | | 登録日 | 1996-03-21 | | 公開日 | 1996-10-14 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | The structure of a Ca(2+)-binding epidermal growth factor-like domain: its role in protein-protein interactions.
Cell(Cambridge,Mass.), 82, 1995
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1TUX
 | | HIGH RESOLUTION CRYSTAL STRUCTURE OF A THERMOSTABLE XYLANASE FROM THERMOASCUS AURANTIACUS | | 分子名称: | XYLANASE | | 著者 | Natesh, R, Bhanumoorthy, P, Vithayathil, P.J, Sekar, K, Ramakumar, S, Viswamitra, M.A. | | 登録日 | 1998-10-29 | | 公開日 | 1999-07-22 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structure at 1.8 A resolution and proposed amino acid sequence of a thermostable xylanase from Thermoascus aurantiacus.
J.Mol.Biol., 288, 1999
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