6B5K
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![BU of 6b5k by Molmil](/molmil-images/mine/6b5k) | Mycobacterium tuberculosis RmlA in complex with Mg/dTTP | 分子名称: | 1,2-ETHANEDIOL, Glucose-1-phosphate thymidylyltransferase, MAGNESIUM ION, ... | 著者 | Brown, H.A, Holden, H.A. | 登録日 | 2017-09-29 | 公開日 | 2018-02-21 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | The structure of glucose-1-phosphate thymidylyltransferase from Mycobacterium tuberculosis reveals the location of an essential magnesium ion in the RmlA-type enzymes. Protein Sci., 27, 2018
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5DU3
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![BU of 5du3 by Molmil](/molmil-images/mine/5du3) | Active form of human C1-inhibitor | 分子名称: | Plasma protease C1 inhibitor | 著者 | Pannu, N.S, Dijk, M, Holkers, J, Voskamp, P, Giannetti, B.M, Waterreus, W.J, van Veen, H.A. | 登録日 | 2015-09-18 | 公開日 | 2016-08-31 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | How Dextran Sulfate Affects C1-inhibitor Activity: A Model for Polysaccharide Potentiation. Structure, 24, 2016
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1I4W
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![BU of 1i4w by Molmil](/molmil-images/mine/1i4w) | THE CRYSTAL STRUCTURE OF THE TRANSCRIPTION FACTOR SC-MTTFB OFFERS INTRIGUING INSIGHTS INTO MITOCHONDRIAL TRANSCRIPTION | 分子名称: | MITOCHONDRIAL REPLICATION PROTEIN MTF1, XENON | 著者 | Schubot, F.D, Chen, C.-J, Rose, J.P, Dailey, T.A, Dailey, H.A, Wang, B.-C. | 登録日 | 2001-02-23 | 公開日 | 2001-10-03 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structure of the transcription factor sc-mtTFB offers insights into mitochondrial transcription. Protein Sci., 10, 2001
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6R7S
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![BU of 6r7s by Molmil](/molmil-images/mine/6r7s) | |
3UEB
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![BU of 3ueb by Molmil](/molmil-images/mine/3ueb) | |
4F4D
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![BU of 4f4d by Molmil](/molmil-images/mine/4f4d) | F337R variant of human ferrochelatase | 分子名称: | CHLORIDE ION, CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER, ... | 著者 | Lanzilotta, W.N, Medlock, A.E, Dailey, T.E, Dailey, H.A. | 登録日 | 2012-05-10 | 公開日 | 2012-09-12 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | F337R Variant of Human Ferrochelatase TO BE PUBLISHED
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4V2S
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![BU of 4v2s by Molmil](/molmil-images/mine/4v2s) | Crystal structure of Hfq in complex with the sRNA RydC | 分子名称: | RNA-BINDING PROTEIN HFQ, RYDC | 著者 | Dimastrogiovanni, D, Frohlich, K.S, Bruce, H.A, Bandyra, K.J, Hohensee, S, Vogel, J, Luisi, B.F. | 登録日 | 2014-10-14 | 公開日 | 2015-01-14 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.48 Å) | 主引用文献 | Recognition of the small regulatory RNA RydC by the bacterial Hfq protein. Elife, 3, 2014
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4MK4
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![BU of 4mk4 by Molmil](/molmil-images/mine/4mk4) | S197C variant of human ferrochelatase. | 分子名称: | CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER, Ferrochelatase, ... | 著者 | Lanzilotta, W.N, Medlock, A.E, Dailey, T.E, Dailey, H.A. | 登録日 | 2013-09-04 | 公開日 | 2013-09-25 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | S197C variant of human ferrochelatase. To be Published
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8R3T
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![BU of 8r3t by Molmil](/molmil-images/mine/8r3t) | Cofactor-free Tau 4R2N isoform | 分子名称: | Microtubule-associated protein tau | 著者 | Limorenko, G, Tatli, M, Kolla, R, Nazarov, S, Weil, M.T, Schondorf, D.C, Geist, D, Reinhardt, P, Ehrnhoefer, D.E, Stahlberg, H, Gasparini, L, Lashuel, H.A. | 登録日 | 2023-11-10 | 公開日 | 2023-12-06 | 最終更新日 | 2024-01-24 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates. Nat Commun, 14, 2023
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8AP4
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5OBN
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![BU of 5obn by Molmil](/molmil-images/mine/5obn) | NMR solution structure of U11/U12 65K protein's C-terminal RRM domain (381-516) | 分子名称: | RNA-binding protein 40 | 著者 | Norppa, A.J, Kauppala, T.M, Heikkinen, H.A, Verma, B, Iwai, H, Frilander, M.J. | 登録日 | 2017-06-28 | 公開日 | 2018-01-24 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | Mutations in the U11/U12-65K protein associated with isolated growth hormone deficiency lead to structural destabilization and impaired binding of U12 snRNA. RNA, 24, 2018
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6ADV
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![BU of 6adv by Molmil](/molmil-images/mine/6adv) | Crystal Structure Analysis of the duplex containing the S2T(2',4'-BNA/LNA)G mismatch pairs | 分子名称: | 5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*(9V9)P*GP*CP*G)-3' | 著者 | Aoyama, H.A, Habuchi, T.H, Yamaguchi, T.Y, Obika, S.O. | 登録日 | 2018-08-02 | 公開日 | 2019-03-27 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Hybridization and Mismatch Discrimination Abilities of 2',4'-Bridged Nucleic Acids Bearing 2-Thiothymine or 2-Selenothymine Nucleobase. J. Org. Chem., 84, 2019
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5KQF
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![BU of 5kqf by Molmil](/molmil-images/mine/5kqf) | (4~{S},6~{S})-4-[2,4-bis(fluoranyl)phenyl]-4-methyl-6-pyrimidin-5-yl-5,6-dihydro-1,3-thiazin-2-amine (compound 12) bound to BACE1 | 分子名称: | (4~{S},6~{S})-4-[2,4-bis(fluoranyl)phenyl]-4-methyl-6-pyrimidin-5-yl-5,6-dihydro-1,3-thiazin-2-amine, Beta-secretase 1 | 著者 | Lewis, H.A, Wu, Y.J, Rajamani, R, Thompson, L.A. | 登録日 | 2016-07-06 | 公開日 | 2016-09-07 | 最終更新日 | 2016-10-05 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Discovery of S3-Truncated, C-6 Heteroaryl Substituted Aminothiazine beta-Site APP Cleaving Enzyme-1 (BACE1) Inhibitors. J.Med.Chem., 59, 2016
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5KR8
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![BU of 5kr8 by Molmil](/molmil-images/mine/5kr8) | (4~{S},6~{S})-4-[2,4-bis(fluoranyl)phenyl]-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine (compound 5) bound to BACE1 | 分子名称: | (4~{S},6~{S})-4-[2,4-bis(fluoranyl)phenyl]-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine, Beta-secretase 1, IODIDE ION | 著者 | Lewis, H.A, Wu, Y.J, Rajamani, R, Thompson, L.A. | 登録日 | 2016-07-07 | 公開日 | 2016-09-07 | 最終更新日 | 2016-10-05 | 実験手法 | X-RAY DIFFRACTION (2.118 Å) | 主引用文献 | Discovery of S3-Truncated, C-6 Heteroaryl Substituted Aminothiazine beta-Site APP Cleaving Enzyme-1 (BACE1) Inhibitors. J.Med.Chem., 59, 2016
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3L4B
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![BU of 3l4b by Molmil](/molmil-images/mine/3l4b) | Crystal Structure of an Octomeric Two-Subunit TrkA K+ Channel Ring Gating Assembly, TM1088A:TM1088B, from Thermotoga maritima | 分子名称: | ADENOSINE MONOPHOSPHATE, TrkA K+ Channel protein TM1088A, TrkA K+ Channel protein TM1088B, ... | 著者 | Deller, M.C, Johnson, H.A, Miller, M, Spraggon, G, Wilson, I.A, Lesley, S.A, Joint Center for Structural Genomics (JCSG) | 登録日 | 2009-12-18 | 公開日 | 2010-02-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.45 Å) | 主引用文献 | Crystal Structure of an Octomeric Two-Subunit TrkA K+ Channel Ring Gating Assembly, TM1088A:TM1088B, from Thermotoga maritima To be Published
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2G3N
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![BU of 2g3n by Molmil](/molmil-images/mine/2g3n) | Crystal structure of the Sulfolobus solfataricus alpha-glucosidase MalA in complex with beta-octyl-glucopyranoside | 分子名称: | Alpha-glucosidase, octyl beta-D-glucopyranoside | 著者 | Ernst, H.A, Lo Leggio, L, Willemoes, M, Leonard, G, Blum, P, Larsen, S. | 登録日 | 2006-02-20 | 公開日 | 2006-05-02 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Structure of the Sulfolobus solfataricus alpha-Glucosidase: Implications for Domain Conservation and Substrate Recognition in GH31. J.Mol.Biol., 358, 2006
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2G3M
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![BU of 2g3m by Molmil](/molmil-images/mine/2g3m) | Crystal structure of the Sulfolobus solfataricus alpha-glucosidase MalA | 分子名称: | Alpha-glucosidase | 著者 | Ernst, H.A, Lo Leggio, L, Willemoes, M, Leonard, G, Blum, P, Larsen, S. | 登録日 | 2006-02-20 | 公開日 | 2006-05-02 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Structure of the Sulfolobus solfataricus alpha-Glucosidase: Implications for Domain Conservation and Substrate Recognition in GH31. J.Mol.Biol., 358, 2006
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3LHB
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![BU of 3lhb by Molmil](/molmil-images/mine/3lhb) | |
7NTH
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![BU of 7nth by Molmil](/molmil-images/mine/7nth) | Structure of TAK1 in complex with compound 54 | 分子名称: | 2-[[5-[[2-[bis(fluoranyl)methoxy]phenyl]methyl-[(2~{R})-1-(methylamino)-1-oxidanylidene-propan-2-yl]carbamoyl]-1~{H}-imidazol-2-yl]carbonyl]isoindole-5-carboxamide, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Veerman, J.J.N, Bruseker, Y.B, Damen, E, Heijne, E.H, van Bruggen, W, Hekking, K.F.W, Winkel, R, Hupp, C.D, Keefe, A.D, Liu, J, Thomson, H.A, Zhang, Y, Cuozzo, J.W, McRiner, A.J, Mulvihill, M.J, van Rijnsbergen, P, Zech, B, Renzetti, L.M, Babiss, L, Mueller, G. | 登録日 | 2021-03-09 | 公開日 | 2021-04-07 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Discovery of 2,4-1 H -Imidazole Carboxamides as Potent and Selective TAK1 Inhibitors. Acs Med.Chem.Lett., 12, 2021
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7NTI
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![BU of 7nti by Molmil](/molmil-images/mine/7nti) | Structure of TAK1 in complex with compound 22 | 分子名称: | DIMETHYL SULFOXIDE, GLYCEROL, Mitogen-activated protein kinase 7,TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, ... | 著者 | Veerman, J.J.N, Bruseker, Y.B, Damen, E, Heijne, E.H, van Bruggen, W, Hekking, K.F.W, Winkel, R, Hupp, C.D, Keefe, A.D, Liu, J, Thomson, H.A, Zhang, Y, Cuozzo, J.W, McRiner, A.J, Mulvihill, M.J, van Rijnsbergen, P, Zech, B, Renzetti, L.M, Babiss, L, Mueller, G. | 登録日 | 2021-03-09 | 公開日 | 2021-04-07 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Discovery of 2,4-1 H -Imidazole Carboxamides as Potent and Selective TAK1 Inhibitors. Acs Med.Chem.Lett., 12, 2021
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4Y66
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4WPF
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![BU of 4wpf by Molmil](/molmil-images/mine/4wpf) | Crystal structure of RORc in complex with a phenyl sulfonamide agonist | 分子名称: | N-[4-(4-acetylpiperazin-1-yl)-2-fluorobenzyl]-N-cyclobutylbenzenesulfonamide, Nuclear receptor ROR-gamma, RHKILHRLLQEGSPS | 著者 | Kiefer, J.R, Wallweber, H.A, de Leon Boenig, G, Hymowitz, S.G. | 登録日 | 2014-10-18 | 公開日 | 2015-01-14 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.202 Å) | 主引用文献 | Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of Action. Acs Med.Chem.Lett., 6, 2015
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3AQI
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![BU of 3aqi by Molmil](/molmil-images/mine/3aqi) | H240A variant of human ferrochelatase | 分子名称: | CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER, Ferrochelatase, ... | 著者 | Lanzilotta, W.N, Medlock, A.E, Dailey, T.A, Dailey, H.A. | 登録日 | 2010-11-03 | 公開日 | 2012-01-25 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | H240A variant of human ferrochelatase To be published
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3C6R
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![BU of 3c6r by Molmil](/molmil-images/mine/3c6r) | Low pH Immature Dengue Virus | 分子名称: | Envelope protein, Peptide pr | 著者 | Yu, I, Zhang, W, Holdway, H.A, Li, L, Kostyuchenko, V.A, Chipman, P.R, Kuhn, R.J, Rossmann, M.G, Chen, J. | 登録日 | 2008-02-05 | 公開日 | 2008-04-22 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (25 Å) | 主引用文献 | Structure of the immature dengue virus at low pH primes proteolytic maturation Science, 319, 2008
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6XDB
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![BU of 6xdb by Molmil](/molmil-images/mine/6xdb) | Crystal structure of IRE1a in complex with G-6904 | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-amino-N-(6-chloro-2-fluoro-3-{[(2-fluorophenyl)sulfonyl]amino}phenyl)-6-(1,3-dimethyl-1H-pyrazol-4-yl)quinazoline-8-carboxamide, Serine/threonine-protein kinase/endoribonuclease IRE1 | 著者 | Wallweber, H.A, Weiru, W. | 登録日 | 2020-06-10 | 公開日 | 2021-04-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Identification of BRaf-Sparing Amino-Thienopyrimidines with Potent IRE1 alpha Inhibitory Activity. Acs Med.Chem.Lett., 11, 2020
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