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4WPF

Crystal structure of RORc in complex with a phenyl sulfonamide agonist

Summary for 4WPF
Entry DOI10.2210/pdb4wpf/pdb
DescriptorNuclear receptor ROR-gamma, RHKILHRLLQEGSPS, N-[4-(4-acetylpiperazin-1-yl)-2-fluorobenzyl]-N-cyclobutylbenzenesulfonamide, ... (4 entities in total)
Functional Keywordsror, rorc, rorg, nuclear receptor, transcription
Biological sourceHomo sapiens (Human)
More
Cellular locationNucleus : P51449
Total number of polymer chains4
Total formula weight65265.34
Authors
Kiefer, J.R.,Wallweber, H.A.,de Leon Boenig, G.,Hymowitz, S.G. (deposition date: 2014-10-18, release date: 2015-01-14, Last modification date: 2023-12-27)
Primary citationRene, O.,Fauber, B.P.,de Leon Boenig, G.,Burton, B.,Eidenschenk, C.,Everett, C.,Gobbi, A.,Hymowitz, S.G.,Johnson, A.R.,Kiefer, J.R.,Liimatta, M.,Lockey, P.,Norman, M.,Ouyang, W.,Wallweber, H.A.,Wong, H.
Minor Structural Change to Tertiary Sulfonamide RORc Ligands Led to Opposite Mechanisms of Action.
Acs Med.Chem.Lett., 6:276-281, 2015
Cited by
PubMed: 25815138
DOI: 10.1021/ml500420y
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.202 Å)
Structure validation

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