4WPF
Crystal structure of RORc in complex with a phenyl sulfonamide agonist
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, D | Nuclear receptor ROR-gamma | polymer | 264 | 30825.5 | 2 | UniProt (P51449) Pfam (PF00104) In PDB | Homo sapiens (Human) | Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,RAR-related orphan receptor C,Retinoid-related orphan receptor-gamma |
2 | B, E | RHKILHRLLQEGSPS | polymer | 11 | 1361.6 | 2 | Homo sapiens | ||
3 | A, D | N-[4-(4-acetylpiperazin-1-yl)-2-fluorobenzyl]-N-cyclobutylbenzenesulfonamide | non-polymer | 445.6 | 2 | Chemie (3SN) | |||
4 | water | water | 18.0 | 266 | Chemie (HOH) |
Sequence modifications
A, D: 262 - 509 (UniProt: P51449)
PDB | External Database | Details |
---|---|---|
Met 246 | - | initiating methionine |
His 247 | - | expression tag |
His 248 | - | expression tag |
His 249 | - | expression tag |
His 250 | - | expression tag |
His 251 | - | expression tag |
His 252 | - | expression tag |
Gly 253 | - | expression tag |
Glu 254 | - | expression tag |
Asn 255 | - | expression tag |
Leu 256 | - | expression tag |
Tyr 257 | - | expression tag |
Phe 258 | - | expression tag |
Gln 259 | - | expression tag |
Gly 260 | - | expression tag |
Ser 261 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 64374.2 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 891.1 | |
All* | Total formula weight | 65265.3 |