4WPF

Crystal structure of RORc in complex with a phenyl sulfonamide agonist

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, D)	Nuclear receptor ROR-gamma	polymer	264	30825.5	2	UniProt (P51449) Pfam (PF00104)	Homo sapiens (Human)	Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,RAR-related orphan receptor C,Retinoid-related orphan receptor-gamma
2	B, D (B, E)	RHKILHRLLQEGSPS	polymer	11	1361.6	2		Homo sapiens
3	E, F (A, D)	N-[4-(4-acetylpiperazin-1-yl)-2-fluorobenzyl]-N-cyclobutylbenzenesulfonamide	non-polymer		445.6	2	Chemie (3SN)
4	G, H, I, J (A, B, D, E)	water	water		18.0	266	Chemie (HOH)

Sequence modifications

A, D: 262 - 509 (UniProt: P51449)

PDB	External Database	Details
Met 246	-	initiating methionine
His 247	-	expression tag
His 248	-	expression tag
His 249	-	expression tag
His 250	-	expression tag
His 251	-	expression tag
His 252	-	expression tag
Gly 253	-	expression tag
Glu 254	-	expression tag
Asn 255	-	expression tag
Leu 256	-	expression tag
Tyr 257	-	expression tag
Phe 258	-	expression tag
Gln 259	-	expression tag
Gly 260	-	expression tag
Ser 261	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	64374.2
Non-Polymers*	Number of molecules	2
	Total formula weight	891.1
All*	Total formula weight	65265.3

*Water molecules are not included.