8R3T

Cofactor-free Tau 4R2N isoform

Summary for 8R3T

Entry DOI	10.2210/pdb8r3t/pdb
EMDB information	18874
Descriptor	Microtubule-associated protein tau (1 entity in total)
Functional Keywords	tau, cleartau, fibrils, aggregation, co-factor-free, heparin-free, protein fibril
Biological source	Homo sapiens (human)
Total number of polymer chains	6
Total formula weight	275519.23
Authors	Limorenko, G.,Tatli, M.,Kolla, R.,Nazarov, S.,Weil, M.T.,Schondorf, D.C.,Geist, D.,Reinhardt, P.,Ehrnhoefer, D.E.,Stahlberg, H.,Gasparini, L.,Lashuel, H.A. (deposition date: 2023-11-10, release date: 2023-12-06, Last modification date: 2024-01-24)
Primary citation	Limorenko, G.,Tatli, M.,Kolla, R.,Nazarov, S.,Weil, M.T.,Schondorf, D.C.,Geist, D.,Reinhardt, P.,Ehrnhoefer, D.E.,Stahlberg, H.,Gasparini, L.,Lashuel, H.A. Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates. Nat Commun, 14:3939-3939, 2023 Cited by PubMed: 37402718 DOI: 10.1038/s41467-023-39314-7 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.1 Å)

Structure validation