3LHB

THE 2.7 ANGSTROM CRYSTAL STRUCTURE OF DEOXYGENATED HEMOGLOBIN FROM THE SEA LAMPREY (PETROMYZON MARINUS)

Summary for 3LHB

Entry DOI	10.2210/pdb3lhb/pdb
Descriptor	PROTEIN (HEMOGLOBIN), PROTOPORPHYRIN IX CONTAINING FE (2 entities in total)
Functional Keywords	hemoglobin, oxygen transport, bohr effect, metal binding protein
Biological source	Petromyzon marinus (sea lamprey)
Total number of polymer chains	12
Total formula weight	202897.98
Authors	Heaslet, H.A.,Royer Jr., W.E. (deposition date: 1999-01-12, release date: 1999-01-20, Last modification date: 2023-09-06)
Primary citation	Heaslet, H.A.,Royer Jr., W.E. The 2.7 A crystal structure of deoxygenated hemoglobin from the sea lamprey (Petromyzon marinus): structural basis for a lowered oxygen affinity and Bohr effect. Structure Fold.Des., 7:517-526, 1999 Cited by PubMed Abstract: The hemoglobins of the sea lamprey are unusual in that cooperativity and sensitivity to pH arise from an equilibrium between a high-affinity monomer and a low-affinity oligomer. Although the crystal structure of the monomeric cyanide derivative has previously been determined, the manner by which oligomerization acts to lower the oxygen affinity and confer a strong Bohr effect has, until now, been speculative. PubMed: 10378271 DOI: 10.1016/S0969-2126(99)80068-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation