4N28
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![BU of 4n28 by Molmil](/molmil-images/mine/4n28) | Crystal structure of Protein Arginine Deiminase 2 (1 mM Ca2+) | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, CALCIUM ION, ... | 著者 | Slade, D.J, Zhang, X, Fang, P, Dreyton, C.J, Zhang, Y, Gross, M.L, Guo, M, Coonrod, S.A, Thompson, P.R. | 登録日 | 2013-10-04 | 公開日 | 2015-02-04 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.879 Å) | 主引用文献 | Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design. Acs Chem.Biol., 10, 2015
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4ZW1
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![BU of 4zw1 by Molmil](/molmil-images/mine/4zw1) | Crystal structure of hBRD4 in complex with BL-BI06 reveals a novel synthesized inhibitor that induces Beclin1-independent/ATG5-dependent autophagic cell death in breast cancer | 分子名称: | 1,2-ETHANEDIOL, 2-(4-hydroxy-3,5-dimethylphenyl)-7-methyl-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(3H)-one, Bromodomain-containing protein 4 | 著者 | Liu, B, Zhang, S, Guo, M, Tian, M. | 登録日 | 2015-05-19 | 公開日 | 2016-06-22 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Crystal structure of hBRD4 in complex with BL-BI06 reveals a novel synthesized inhibitor that induces Beclin1-independent/ATG5-dependent autophagic cell death in breast cancer To Be Published
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5X07
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![BU of 5x07 by Molmil](/molmil-images/mine/5x07) | Crystal structure of FOXA2 DNA binding domain bound to a full consensus DNA site | 分子名称: | DNA (5'-D(*CP*AP*AP*AP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*GP*A)-3'), DNA (5'-D(*TP*CP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*TP*TP*TP*G)-3'), Hepatocyte nuclear factor 3-beta | 著者 | Li, J, Guo, M, Zhou, Z, Jiang, L, Chen, X, Qu, L, Wu, D, Chen, Z, Chen, L, Chen, Y. | 登録日 | 2017-01-20 | 公開日 | 2017-08-16 | 最終更新日 | 2017-09-27 | 実験手法 | X-RAY DIFFRACTION (2.796 Å) | 主引用文献 | Structure of the Forkhead Domain of FOXA2 Bound to a Complete DNA Consensus Site Biochemistry, 56, 2017
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5XP5
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![BU of 5xp5 by Molmil](/molmil-images/mine/5xp5) | C-Src in complex with ATP-Chf | 分子名称: | MAGNESIUM ION, Proto-oncogene tyrosine-protein kinase Src, [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-[(S)-fluoranyl-[oxidanyl(phosphonooxy)phosphoryl]methyl]phosphinic acid | 著者 | Duan, Y, Guo, M, Dai, S, Chen, L, Chen, Y. | 登録日 | 2017-06-01 | 公開日 | 2018-02-07 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.101 Å) | 主引用文献 | Remarkably Stereospecific Utilization of ATP alpha , beta-Halomethylene Analogues by Protein Kinases. J. Am. Chem. Soc., 139, 2017
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5XBL
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![BU of 5xbl by Molmil](/molmil-images/mine/5xbl) | Structure of nuclease in complex with associated protein | 分子名称: | Associated protein, CRISPR-associated endonuclease Cas9/Csn1, RNA (98-MER) | 著者 | Dong, D, Guo, M, Wang, S, Zhu, Y, Huang, Z. | 登録日 | 2017-03-20 | 公開日 | 2017-06-14 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (3.052 Å) | 主引用文献 | Structural basis of CRISPR-SpyCas9 inhibition by an anti-CRISPR protein Nature, 546, 2017
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4YCU
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![BU of 4ycu by Molmil](/molmil-images/mine/4ycu) | Crystal structure of cladosporin in complex with human lysyl-tRNA synthetase | 分子名称: | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, GLYCEROL, LYSINE, ... | 著者 | Fang, P, Wang, J, Guo, M. | 登録日 | 2015-02-20 | 公開日 | 2015-06-10 | 最終更新日 | 2019-12-25 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural Basis for Specific Inhibition of tRNA Synthetase by an ATP Competitive Inhibitor. Chem. Biol., 22, 2015
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4YCV
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4YCW
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![BU of 4ycw by Molmil](/molmil-images/mine/4ycw) | Crystal structure of cladosporin in complex with plasmodium like human lysyl-tRNA synthetase mutant | 分子名称: | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, LYSINE, Lysine--tRNA ligase, ... | 著者 | Fang, P, Wang, J, Guo, M. | 登録日 | 2015-02-20 | 公開日 | 2015-06-10 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural Basis for Specific Inhibition of tRNA Synthetase by ATP Competitive Inhibitor Chem.Biol., 22, 2015
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8H2I
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![BU of 8h2i by Molmil](/molmil-images/mine/8h2i) | Near-atomic structure of five-fold averaged PBCV-1 capsid | 分子名称: | MCPv1, MCPv2, MCPv3, ... | 著者 | Shao, Q, Agarkova, I.V, Noel, E.A, Dunigan, D.D, Liu, Y, Wang, A, Guo, M, Xie, L, Zhao, X, Rossmann, M.G, Van Etten, J.L, Klose, T, Fang, Q. | 登録日 | 2022-10-06 | 公開日 | 2022-11-16 | 最終更新日 | 2023-09-06 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Near-atomic, non-icosahedrally averaged structure of giant virus Paramecium bursaria chlorella virus 1. Nat Commun, 13, 2022
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8HLL
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![BU of 8hll by Molmil](/molmil-images/mine/8hll) | Crystal structure of p53/BCL2 fusion complex (complex 1) | 分子名称: | Apoptosis regulator Bcl-2, Cellular tumor antigen p53, ZINC ION | 著者 | Wei, H, Guo, M, Wang, H, Chen, Y. | 登録日 | 2022-11-30 | 公開日 | 2023-07-26 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity. Nat Commun, 14, 2023
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3SZX
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![BU of 3szx by Molmil](/molmil-images/mine/3szx) | Crystal Structure of the Triplet Repeat in Myotonic Dystrophy Reveals Heterogeneous 1x1 Nucleotide UU Internal Loop Conformations | 分子名称: | RNA (5'-R(P*UP*UP*GP*GP*GP*CP*CP*UP*GP*CP*UP*GP*CP*UP*GP*GP*UP*CP*C)-3') | 著者 | Kumar, A, Park, H, Pengfei, F, Parkesh, R, Guo, M, Nettles, K.W, Disney, M.D. | 登録日 | 2011-07-19 | 公開日 | 2012-04-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.204 Å) | 主引用文献 | Crystal Structure of the Triplet Repeat in Myotonic Dystrophy Reveals Heterogeneous 1x1 Nucleotide UU Internal Loop Conformations Biochemistry, 50, 2011
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3SYW
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![BU of 3syw by Molmil](/molmil-images/mine/3syw) | Crystal Structure of the Triplet Repeat in Myotonic Dystrophy Reveals Heterogeneous 1x1 Nucleotide UU Internal Loop Conformations | 分子名称: | PHOSPHATE ION, RNA (5'-R(*UP*UP*GP*GP*GP*CP*CP*UP*GP*CP*UP*GP*CP*UP*GP*GP*UP*CP*C)-3') | 著者 | Kumar, A, Park, H, Pengfei, F, Parkesh, R, Guo, M, Nettles, K.W, Disney, M.D. | 登録日 | 2011-07-18 | 公開日 | 2012-04-25 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | 主引用文献 | Crystal Structure of the Triplet Repeat in Myotonic Dystrophy Reveals Heterogeneous 1x1 Nucleotide UU Internal Loop Conformations Biochemistry, 50, 2011
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3SJ2
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![BU of 3sj2 by Molmil](/molmil-images/mine/3sj2) | A Crystal Structure of a Model of the Repeating r(CGG) Transcript Found in Fragile X Syndrome | 分子名称: | ACETATE ION, RNA (5'-R(*UP*UP*GP*GP*GP*CP*CP*GP*GP*CP*GP*GP*CP*GP*GP*GP*UP*CP*C)-3'), RNA (5'-R(P*GP*GP*GP*CP*CP*GP*GP*CP*GP*GP*CP*GP*GP*GP*UP*CP*C)-3') | 著者 | Kumar, A, Pengfei, F, Park, H, Nettles, K, Guo, M, Disney, M.D. | 登録日 | 2011-06-20 | 公開日 | 2011-08-03 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | 主引用文献 | A Crystal Structure of a Model of the Repeating r(CGG) Transcript Found in Fragile X Syndrome. Chembiochem, 12, 2011
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3UV9
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![BU of 3uv9 by Molmil](/molmil-images/mine/3uv9) | Structure of the rhesus monkey TRIM5alpha deltav1 PRYSPRY domain | 分子名称: | Tripartite motif-containing protein 5 | 著者 | Biris, N, Yang, Y, Taylor, A.B, Tomashevskii, A, Guo, M, Hart, P.J, Diaz-Griffero, F, Ivanov, D. | 登録日 | 2011-11-29 | 公開日 | 2012-08-08 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.549 Å) | 主引用文献 | Structure of the rhesus monkey TRIM5alpha PRYSPRY domain, the HIV capsid recognition module. Proc.Natl.Acad.Sci.USA, 109, 2012
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6AKO
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![BU of 6ako by Molmil](/molmil-images/mine/6ako) | Crystal Structure of FOXC2 DBD Bound to DBE2 DNA | 分子名称: | DNA (5'-D(CP*AP*AP*AP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*GP*A)-3'), DNA (5'-D(TP*CP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*TP*TP*TP*G)-3'), Forkhead box protein C2, ... | 著者 | Chen, X, Wei, H, Li, J, Liang, X, Dai, S, Jiang, L, Guo, M, Chen, Y. | 登録日 | 2018-09-03 | 公開日 | 2019-02-06 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.396 Å) | 主引用文献 | Structural basis for DNA recognition by FOXC2. Nucleic Acids Res., 47, 2019
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6AKP
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![BU of 6akp by Molmil](/molmil-images/mine/6akp) | Crystal Structural of FOXC2 DNA binding domain bound to PC promoter | 分子名称: | DNA (5'-D(AP*CP*AP*CP*AP*AP*AP*TP*AP*TP*TP*TP*GP*TP*GP*T)-3'), Forkhead box protein C2, MAGNESIUM ION | 著者 | Chen, X, Wei, H, Li, J, Liang, X, Dai, S, Jiang, L, Guo, M, Chen, Y. | 登録日 | 2018-09-03 | 公開日 | 2019-02-06 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.323 Å) | 主引用文献 | Structural basis for DNA recognition by FOXC2. Nucleic Acids Res., 47, 2019
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5YZX
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![BU of 5yzx by Molmil](/molmil-images/mine/5yzx) | Crystal structure of E.coli LysU T146D mutant | 分子名称: | BIS(ADENOSINE)-5'-TETRAPHOSPHATE, CALCIUM ION, Lysine--tRNA ligase, ... | 著者 | Fang, P, Guo, M. | 登録日 | 2017-12-16 | 公開日 | 2018-12-19 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | A proposed role for MSC to reserve the canonical function in high eukaryotes prior to stimuli To Be Published
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4AX2
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![BU of 4ax2 by Molmil](/molmil-images/mine/4ax2) | New Type VI-secreted toxins and self-resistance proteins in Serratia marcescens | 分子名称: | 1,2-ETHANEDIOL, IODIDE ION, RAP1B | 著者 | English, G, Trunk, K, Rao, V.A, Srikannathasan, V, Fritsch, M.J, Guo, M, Hunter, W.N, Coulthurst, S.J. | 登録日 | 2012-06-07 | 公開日 | 2012-09-19 | 最終更新日 | 2013-07-17 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | New Secreted Toxins and Immunity Proteins Encoded within the Type Vi Secretion System Gene Cluster of Serratia Marcescens Mol.Microbiol., 86, 2012
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6J65
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![BU of 6j65 by Molmil](/molmil-images/mine/6j65) | Crystal structure of human HINT1 mutant complexing with AP4A II | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, BIS(ADENOSINE)-5'-TETRAPHOSPHATE, Histidine triad nucleotide-binding protein 1 | 著者 | Wang, J, Fang, P, Guo, M. | 登録日 | 2019-01-14 | 公開日 | 2019-09-25 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Second messenger Ap4A polymerizes target protein HINT1 to transduce signals in Fc epsilon RI-activated mast cells. Nat Commun, 10, 2019
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7XUZ
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![BU of 7xuz by Molmil](/molmil-images/mine/7xuz) | Crystal structure of a HDAC4-MEF2A-DNA ternary complex | 分子名称: | DNA (5'-D(*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*T)-3'), DNA (5'-D(P*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*A)-3'), Histone deacetylase 4, ... | 著者 | Dai, S.Y, Guo, L, Dey, R, Guo, M, Bates, D, Cayford, J, Chen, X.J, Wei, X.D, Chen, L, Chen, Y.H. | 登録日 | 2022-05-20 | 公開日 | 2023-11-29 | 最終更新日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (3.591 Å) | 主引用文献 | Structural insights into the HDAC4-MEF2A-DNA complex and its implication in long-range transcriptional regulation. Nucleic Acids Res., 52, 2024
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7Y8T
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![BU of 7y8t by Molmil](/molmil-images/mine/7y8t) | Structure of Cas7-11-crRNA in complex with TPR-CHAT | 分子名称: | CHAT domain protein, RAMP superfamily protein, RNA (37-MER), ... | 著者 | Wang, S, Guo, M, Zhu, Y, Huang, Z. | 登録日 | 2022-06-24 | 公開日 | 2023-06-28 | 最終更新日 | 2024-01-10 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Cryo-EM structure of the type III-E CRISPR-Cas effector gRAMP in complex with TPR-CHAT. Cell Res., 32, 2022
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7Y8Y
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![BU of 7y8y by Molmil](/molmil-images/mine/7y8y) | Structure of Cas7-11-crRNA-tgRNA in complex with TPR-CHAT | 分子名称: | CHAT domain protein, RAMP superfamily protein, RNA (37-MER), ... | 著者 | Wang, S, Guo, M, Zhu, Y, Huang, Z. | 登録日 | 2022-06-24 | 公開日 | 2023-06-28 | 最終更新日 | 2024-01-10 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Cryo-EM structure of the type III-E CRISPR-Cas effector gRAMP in complex with TPR-CHAT. Cell Res., 32, 2022
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