4YCV

Crystal structure of cladosporin in complex with plasmodium lysyl-tRNA synthetase

Summary for 4YCV

• Entry DOI: 10.2210/pdb4ycv/pdb
• Related: 4YCU 4YCW
• Descriptor: Lysine--tRNA ligase, cladosporin (3 entities in total)
• Functional Keywords: inhibitor, complex, lysrs, cladosporin, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Plasmodium falciparum (isolate NF54)
• Total number of polymer chains: 4
• Total formula weight: 240293.84

Authors

Fang, P.,Wang, J.,Guo, M. (deposition date: 2015-02-20, release date: 2015-06-24, Last modification date: 2023-09-27)

• Primary citation: Fang, P.,Han, H.,Wang, J.,Chen, K.,Chen, X.,Guo, M.; Structural Basis for Specific Inhibition of tRNA Synthetase by an ATP Competitive Inhibitor.; Chem.Biol., 22:734-744, 2015; PubMed: 26074468; DOI: 10.1016/j.chembiol.2015.05.007

Experimental method

X-RAY DIFFRACTION (3.406 Å)