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PDB: 95 件
8E97
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PYD-106-bound Human GluN1a-GluN2C NMDA receptor in splayed conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
著者Chou, T.-H, Furukawa, H.
登録日2022-08-26
公開日2022-12-07
最終更新日2022-12-14
実験手法ELECTRON MICROSCOPY (4.19 Å)
主引用文献Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
8E92
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D-cycloserine and glutamate bound Human GluN1a-GluN2C NMDA receptor in intact conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
著者Chou, T.-H, Furukawa, H.
登録日2022-08-26
公開日2022-12-07
最終更新日2022-12-14
実験手法ELECTRON MICROSCOPY (3.96 Å)
主引用文献Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
8E93
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D-cycloserine and glutamate bound Human GluN1a-GluN2C NMDA receptor in splayed conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
著者Chou, T.-H, Furukawa, H.
登録日2022-08-26
公開日2022-12-07
最終更新日2022-12-14
実験手法ELECTRON MICROSCOPY (3.71 Å)
主引用文献Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
8E99
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Human GluN1a-GluN2A-GluN2C triheteromeric NMDA receptor in complex with Nb-4
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ...
著者Chou, T.-H, Furukawa, H.
登録日2022-08-26
公開日2022-12-07
最終更新日2022-12-14
実験手法ELECTRON MICROSCOPY (4.24 Å)
主引用文献Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
8E96
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Glycine and glutamate bound Human GluN1a-GluN2D NMDA receptor
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLUTAMIC ACID, GLYCINE, ...
著者Kang, H, Furukawa, H.
登録日2022-08-26
公開日2022-12-07
最終更新日2022-12-14
実験手法ELECTRON MICROSCOPY (3.38 Å)
主引用文献Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
8E98
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D-cycloserine and glutamate bound Human GluN1a-GluN2C NMDA receptor in nanodisc - intact conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ...
著者Chou, T.-H, Furukawa, H.
登録日2022-08-26
公開日2022-12-07
最終更新日2022-12-14
実験手法ELECTRON MICROSCOPY (3.75 Å)
主引用文献Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
Mol.Cell, 82, 2022
3H5W
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Crystal structure of the GluR2-ATD in space group P212121 without solvent
分子名称: Glutamate receptor 2
著者Jin, R, Singh, S.K, Gu, S, Furukawa, H, Sobolevsky, A, Zhou, J, Jin, Y, Gouaux, E.
登録日2009-04-22
公開日2009-06-09
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.686 Å)
主引用文献Crystal structure and association behaviour of the GluR2 amino-terminal domain.
Embo J., 28, 2009
5B3J
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BU of 5b3j by Molmil
Activation of NMDA receptors and the mechanism of inhibition by ifenprodil
分子名称: Fab, heavy chain, light chain, ...
著者Tajima, N, Karakas, E, Grant, T, Simorowski, N, Diaz-Avalos, R, Grigorieff, N, Furukawa, H.
登録日2016-03-01
公開日2016-05-11
最終更新日2022-03-23
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Activation of NMDA receptors and the mechanism of inhibition by ifenprodil
Nature, 534, 2016
7TE9
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BU of 7te9 by Molmil
Cryo-EM structure of GluN1b-2B NMDAR complexed to Fab2 class1
分子名称: Fab2 heavy chain, Fab2 light chain, Glutamate receptor ionotropic, ...
著者Tajima, N, Furukawa, H.
登録日2022-01-04
公開日2022-03-02
実験手法ELECTRON MICROSCOPY (3.92 Å)
主引用文献Development and characterization of functional antibodies targeting NMDA receptors.
Nat Commun, 13, 2022
7TE4
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Crystal structure of Fab2 anti-GluN2B antibody
分子名称: Fab anti-GluN2B antibody, heavy chain, Fab2 anti-GluN2B antibody, ...
著者Tajima, N, Furukawa, H.
登録日2022-01-04
公開日2022-03-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.456 Å)
主引用文献Development and characterization of functional antibodies targeting NMDA receptors.
Nat Commun, 13, 2022
7TES
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BU of 7tes by Molmil
Cryo-EM structure of GluN1b-2B NMDAR in complex with Fab5 in Non-active1 conformation
分子名称: Fab5 heavy chain, Fab5 light chain, Glutamate receptor ionotropic, ...
著者Tajima, N, Furukawa, H.
登録日2022-01-05
公開日2022-03-02
実験手法ELECTRON MICROSCOPY (4.7 Å)
主引用文献Development and characterization of functional antibodies targeting NMDA receptors.
Nat Commun, 13, 2022
7TEB
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BU of 7teb by Molmil
Cryo-EM structure of GluN1b-2B NMDAR complexed to Fab2 non-active1-like
分子名称: Fab2 heavy chain, Fab2 light chain, Glutamate receptor ionotropic, ...
著者Tajima, N, Furukawa, H.
登録日2022-01-04
公開日2022-03-02
実験手法ELECTRON MICROSCOPY (4.23 Å)
主引用文献Development and characterization of functional antibodies targeting NMDA receptors.
Nat Commun, 13, 2022
7TE6
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BU of 7te6 by Molmil
Crystal structure of GluN1b-2B ATD complexed to Fab5 anti-GluN2B antibody
分子名称: Fab5 heavy chain, Fab5 light chain, Glutamate receptor ionotropic, ...
著者Regan, M, Tajima, N, Furukawa, H.
登録日2022-01-04
公開日2022-03-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (4.55 Å)
主引用文献Development and characterization of functional antibodies targeting NMDA receptors.
Nat Commun, 13, 2022
7TER
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BU of 7ter by Molmil
Cryo-EM structure of GluN1b-2B NMDAR in complex with Fab5 non-active2 conformation
分子名称: Fab5 heavy chain, Fab5 light chain, Glutamate receptor ionotropic, ...
著者Tajima, N, Furukawa, H.
登録日2022-01-05
公開日2022-03-02
実験手法ELECTRON MICROSCOPY (5.23 Å)
主引用文献Development and characterization of functional antibodies targeting NMDA receptors.
Nat Commun, 13, 2022
7TEE
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BU of 7tee by Molmil
Cryo-EM structure of GluN1b-2B NMDAR complexed to Fab2 Non-active2-like
分子名称: Fab2 heavy chain, Fab2 light chain, Glutamate receptor ionotropic, ...
著者Tajima, N, Furukawa, H.
登録日2022-01-04
公開日2022-03-02
実験手法ELECTRON MICROSCOPY (6.59 Å)
主引用文献Development and characterization of functional antibodies targeting NMDA receptors.
Nat Commun, 13, 2022
7TET
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BU of 7tet by Molmil
Cryo-EM structure of GluN1b-2B NMDAR in complex with Fab5 in non-active2-like conformation
分子名称: Fab5 heavy chain, Fab5 light chain, Glutamate receptor ionotropic, ...
著者Tajima, N, Furukawa, H.
登録日2022-01-05
公開日2022-03-02
実験手法ELECTRON MICROSCOPY (4.45 Å)
主引用文献Development and characterization of functional antibodies targeting NMDA receptors.
Nat Commun, 13, 2022
7TEQ
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BU of 7teq by Molmil
Cryo-EM structure of GluN1b-2B NMDAR in complex with Fab5 active conformation
分子名称: Fab5 heavy chain, Fab5 light chain, Glutamate receptor ionotropic, ...
著者Tajima, N, Furukawa, H.
登録日2022-01-05
公開日2022-03-02
実験手法ELECTRON MICROSCOPY (7.51 Å)
主引用文献Development and characterization of functional antibodies targeting NMDA receptors.
Nat Commun, 13, 2022
3JPW
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BU of 3jpw by Molmil
Crystal structure of amino terminal domain of the NMDA receptor subunit NR2B
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Glutamate [NMDA] receptor subunit epsilon-2, ...
著者Karakas, E, Simorowski, N, Furukawa, H.
登録日2009-09-04
公開日2009-12-08
最終更新日2021-10-13
実験手法X-RAY DIFFRACTION (2.803 Å)
主引用文献Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit.
Embo J., 28, 2009
3JPY
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BU of 3jpy by Molmil
Crystal structure of the zinc-bound amino terminal domain of the NMDA receptor subunit NR2B
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Glutamate [NMDA] receptor subunit epsilon-2, ...
著者Karakas, E, Simorowski, N, Furukawa, H.
登録日2009-09-04
公開日2009-12-08
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.209 Å)
主引用文献Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit.
Embo J., 28, 2009
8G18
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BU of 8g18 by Molmil
Heterodimer of the GluN1b-GluN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor 93-108
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, NMDA 1, ...
著者Regan, M.C, Furukawa, H.
登録日2023-02-01
公開日2023-03-01
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Novel GluN2B-Selective NMDA Receptor Negative Allosteric Modulator Possesses Intrinsic Analgesic Properties and Enhances Analgesia of Morphine in a Rodent Tail Flick Pain Model.
Acs Chem Neurosci, 14, 2023
4JWY
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BU of 4jwy by Molmil
GluN2D ligand-binding core in complex with propyl-NHP5G
分子名称: (2R)-amino(1-hydroxy-4-propyl-1H-pyrazol-5-yl)ethanoic acid, Glutamate receptor ionotropic, NMDA 2D
著者Hansen, K.B, Tajima, N, Risgaard, R, Perszyk, R.E, Jorgensen, L, Vance, K.M, Ogden, K.K, Clausen, R.P, Furukawa, H, Traynelis, S.F.
登録日2013-03-27
公開日2013-05-29
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural determinants of agonist efficacy at the glutamate binding site of N-methyl-d-aspartate receptors.
Mol.Pharmacol., 84, 2013
4JWX
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BU of 4jwx by Molmil
GluN2A ligand-binding core in complex with propyl-NHP5G
分子名称: (2R)-amino(1-hydroxy-4-propyl-1H-pyrazol-5-yl)ethanoic acid, GluN2A
著者Hansen, K.B, Tajima, N, Risgaard, R, Perszyk, R.E, Jorgensen, L, Vance, K.M, Ogden, K.K, Clausen, R.P, Furukawa, H, Traynelis, S.F.
登録日2013-03-27
公開日2013-05-29
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural determinants of agonist efficacy at the glutamate binding site of N-methyl-d-aspartate receptors.
Mol.Pharmacol., 84, 2013
4NF5
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BU of 4nf5 by Molmil
Crystal structure of GluN1/GluN2A ligand-binding domain in complex with glycine and D-AP5
分子名称: 5-phosphono-D-norvaline, GLYCEROL, GLYCINE, ...
著者Jespersen, A, Tajima, N, Furukawa, H.
登録日2013-10-30
公開日2014-03-12
最終更新日2017-08-09
実験手法X-RAY DIFFRACTION (1.903 Å)
主引用文献Structural Insights into Competitive Antagonism in NMDA Receptors.
Neuron, 81, 2014
6E7T
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BU of 6e7t by Molmil
Heterodimer of the GluN1b-GluN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor 93-6
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Glutamate receptor ionotropic, ...
著者Regan, M.C, Furukawa, H.
登録日2018-07-27
公開日2019-01-30
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors
Nat Commun, 10, 2019
6E7S
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BU of 6e7s by Molmil
Heterodimer of the GluN1b-GluN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor 93-5
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
著者Regan, M.C, Furukawa, H.
登録日2018-07-27
公開日2019-01-30
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.72 Å)
主引用文献Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors
Nat Commun, 10, 2019

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