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PDB: 50 件
2OKW
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BU of 2okw by Molmil
A non-invasive GFP-based biosensor for mercury ions
分子名称: Green fluorescent protein
著者Chapleau, R.R, Blomberg, R, Ford, P.C, Sagermann, M.
登録日2007-01-17
公開日2007-12-04
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Design of a highly specific and noninvasive biosensor suitable for real-time in vivo imaging of mercury (II) uptake.
Protein Sci., 17, 2008
7Z3K
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BU of 7z3k by Molmil
Autotaxin in complex with orthosteric site-binder CpdA
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 7alpha-hydroxycholesterol, CALCIUM ION, ...
著者Salgado-Polo, F, Ford, P, Heckmann, B, Perrakis, A.
登録日2022-03-02
公開日2023-01-25
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Autotaxin facilitates selective LPA receptor signaling.
Cell Chem Biol, 30, 2023
7Z3L
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BU of 7z3l by Molmil
Autotaxin in complex with hybrid compound ziritaxestat (GLPG1690)
分子名称: 2-[[2-ethyl-8-methyl-6-[4-[2-(3-oxidanylazetidin-1-yl)-2-oxidanylidene-ethyl]piperazin-1-yl]imidazo[1,2-a]pyridin-3-yl]-methyl-amino]-4-(4-fluorophenyl)-1,3-thiazole-5-carbonitrile, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Salgado-Polo, F, Ford, P, Heckmann, B, Perrakis, A.
登録日2022-03-02
公開日2023-01-25
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Autotaxin facilitates selective LPA receptor signaling.
Cell Chem Biol, 30, 2023
4V5M
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BU of 4v5m by Molmil
tRNA tranlocation on the 70S ribosome: the pre-translocational translocation intermediate TI(PRE)
分子名称: 16S RRNA, 23S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, ...
著者Ratje, A.H, Loerke, J, Mikolajka, A, Bruenner, M, Hildebrand, P.W, Starosta, A.L, Doenhoefer, A, Connell, S.R, Fucini, P, Mielke, T, Whitford, P.C, Onuchic, J.N, Yu, Y, Sanbonmatsu, K.Y, Hartmann, R.K, Penczek, P.A, Wilson, D.N, Spahn, C.M.T.
登録日2010-10-01
公開日2014-07-09
最終更新日2019-12-11
実験手法ELECTRON MICROSCOPY (7.8 Å)
主引用文献Head Swivel on the Ribosome Facilitates Translocation by Means of Intra-Subunit tRNA Hybrid Sites.
Nature, 468, 2010
2VJ2
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BU of 2vj2 by Molmil
Human Jagged-1, domains DSL and EGFs1-3
分子名称: D-MALATE, JAGGED-1
著者Johnson, S, Cordle, J, Tay, J.Z, Roversi, P, Handford, P.A, Lea, S.M.
登録日2007-12-06
公開日2008-07-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献A Conserved Face of the Jagged/Serrate Dsl Domain is Involved in Notch Trans-Activation and Cis-Inhibition.
Nat.Struct.Mol.Biol., 15, 2008
3N5N
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BU of 3n5n by Molmil
Crystal structure analysis of the catalytic domain and interdomain connector of human MutY homologue
分子名称: A/G-specific adenine DNA glycosylase, ACETATE ION, IRON/SULFUR CLUSTER
著者Toth, E.A, Luncsford, P.J.
登録日2010-05-25
公開日2010-11-10
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献A structural hinge in eukaryotic MutY homologues mediates catalytic activity and Rad9-Rad1-Hus1 checkpoint complex interactions.
J.Mol.Biol., 403, 2010
4V5N
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BU of 4v5n by Molmil
tRNA translocation on the 70S ribosome: the post- translocational translocation intermediate TI(POST)
分子名称: 16S RRNA, 23S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, ...
著者Ratje, A.H, Loerke, J, Mikolajka, A, Bruenner, M, Hildebrand, P.W, Starosta, A.L, Doenhoefer, A, Connell, S.R, Fucini, P, Mielke, T, Whitford, P.C, Onuchic, J.N, Yu, Y, Sanbonmatsu, K.Y, Hartmann, R.K, Penczek, P.A, Wilson, D.N, Spahn, C.M.T.
登録日2010-10-21
公開日2014-07-09
最終更新日2019-12-11
実験手法ELECTRON MICROSCOPY (7.6 Å)
主引用文献Head Swivel on the Ribosome Facilitates Translocation by Means of Intra-Subunit tRNA Hybrid Sites.
Nature, 468, 2010
5FMA
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BU of 5fma by Molmil
human Notch 1, EGF 4-7
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, CHLORIDE ION, ...
著者Weisshuhn, P.C, Sheppard, D, Taylor, P, Whiteman, P, Lea, S.M, Handford, P.A, Redfield, C.
登録日2015-11-02
公開日2016-04-13
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.46 Å)
主引用文献Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies.
Structure, 24, 2016
5FM9
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BU of 5fm9 by Molmil
human Notch 1, EGF 4-7
分子名称: CALCIUM ION, NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
著者Weisshuhn, P.C, Sheppard, D, Taylor, P, Whiteman, P, Lea, S.M, Handford, P.A, Redfield, C.
登録日2015-11-02
公開日2016-04-20
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.92 Å)
主引用文献Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies.
Structure, 24, 2016
5MWF
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BU of 5mwf by Molmil
Human Jagged2 C2-EGF2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
著者Suckling, R.J, Handford, P.A, Lea, S.M.
登録日2017-01-18
公開日2017-06-14
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.
EMBO J., 36, 2017
5MW7
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BU of 5mw7 by Molmil
Human Jagged2 C2-EGF3
分子名称: Protein jagged-2, alpha-L-fucopyranose
著者Suckling, R.J, Handford, P.A, Lea, S.M.
登録日2017-01-18
公開日2017-06-14
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.
EMBO J., 36, 2017
5MWB
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BU of 5mwb by Molmil
Human Notch-2 EGF11-13
分子名称: CALCIUM ION, Neurogenic locus notch homolog protein 2, alpha-L-fucopyranose, ...
著者Suckling, R.J, Handford, P.A, Lea, S.M.
登録日2017-01-18
公開日2017-06-14
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.
EMBO J., 36, 2017
5MW5
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BU of 5mw5 by Molmil
Human Jagged2 C2-EGF2
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Protein jagged-2
著者Suckling, R.J, Handford, P.A, Lea, S.M.
登録日2017-01-18
公開日2017-06-14
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.
EMBO J., 36, 2017
3RBH
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BU of 3rbh by Molmil
Structure of alginate export protein AlgE from Pseudomonas aeruginosa
分子名称: (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, 1,2-ETHANEDIOL, Alginate production protein AlgE, ...
著者Whitney, J.C, Hay, I.D, Li, C, Eckford, P.D, Robinson, H, Amaya, M.F, Wood, L.F, Ohman, D.E, Bear, C.E, Rehm, B.H, Howell, P.L.
登録日2011-03-29
公開日2011-07-27
最終更新日2011-08-24
実験手法X-RAY DIFFRACTION (2.301 Å)
主引用文献Structural basis for alginate secretion across the bacterial outer membrane.
Proc.Natl.Acad.Sci.USA, 108, 2011
5MVX
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BU of 5mvx by Molmil
Human DLL4 C2-EGF3
分子名称: Delta-like protein 4, alpha-L-fucopyranose
著者Suckling, R.J, Handford, P.A, Lea, S.M.
登録日2017-01-17
公開日2017-06-14
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.17 Å)
主引用文献Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.
EMBO J., 36, 2017
2JMG
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BU of 2jmg by Molmil
Solution structure of V7R mutant of HIV-1 myristoylated matrix protein
分子名称: Gag polyprotein, MYRISTIC ACID
著者Saad, J.S, Loeliger, E, Luncsford, P, Liriano, M, Tai, J, Kim, A, Miller, J, Joshi, A, Freed, E.O, Summers, M.F.
登録日2006-11-11
公開日2007-02-06
最終更新日2023-12-20
実験手法SOLUTION NMR
主引用文献Point mutations in the HIV-1 matrix protein turn off the myristyl switch.
J.Mol.Biol., 366, 2007
2BOU
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BU of 2bou by Molmil
EGF Domains 1,2,5 of human EMR2, a 7-TM immune system molecule, in complex with barium.
分子名称: BARIUM ION, CACODYLATE ION, CALCIUM ION, ...
著者Abbott, R.J.M, Spendlove, I, Roversi, P, Teriete, P, Knott, V, Handford, P.A, McDonnell, J.M, Lea, S.M.
登録日2005-04-14
公開日2006-10-18
最終更新日2017-01-25
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and Functional Characterization of a Novel T Cell Receptor Co-Regulatory Protein Complex, Cd97-Cd55.
J.Biol.Chem., 282, 2007
1LMJ
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BU of 1lmj by Molmil
NMR Study of the Fibrillin-1 cbEGF12-13 Pair of Ca2+ Binding Epidermal Growth Factor-like Domains
分子名称: CALCIUM ION, fibrillin 1
著者Smallridge, R.S, Whiteman, P, Werner, J.M, Campbell, I.D, Handford, P.A, Downing, A.K.
登録日2002-05-02
公開日2003-04-29
最終更新日2022-02-23
実験手法SOLUTION NMR
主引用文献Solution Structure and Dynamics of a Calcium Binding Epidermal Growth Factor-like Domain Pair from the Neonatal Region of Human Fibrillin-1.
J.Biol.Chem., 278, 2003
5MS9
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BU of 5ms9 by Molmil
Solution structure of Human Fibrillin-1 EGF2-EGF3-Hybrid1-cbEGF1 four domain fragment
分子名称: CALCIUM ION, Fibrillin-1
著者Robertson, I.B, Redfield, C, Handford, P.A.
登録日2017-01-01
公開日2017-08-09
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献The N-Terminal Region of Fibrillin-1 Mediates a Bipartite Interaction with LTBP1.
Structure, 25, 2017
2NV3
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BU of 2nv3 by Molmil
Solution structure of L8A mutant of HIV-1 myristoylated matrix protein
分子名称: Gag polyprotein, MYRISTIC ACID
著者Saad, J.S, Loeliger, E, Luncsford, P, Liriano, M, Tai, J, Kim, A, Miller, J, Joshi, A, Freed, E.O, Summers, M.F.
登録日2006-11-10
公開日2007-02-06
最終更新日2023-12-27
実験手法SOLUTION NMR
主引用文献Point mutations in the HIV-1 matrix protein turn off the myristyl switch.
J.Mol.Biol., 366, 2007
4D0F
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BU of 4d0f by Molmil
Human Notch1 EGF domains 11-13 mutant T466A
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
著者Taylor, P, Takeuchi, H, Sheppard, D, Chillakuri, C, Lea, S.M, Haltiwanger, R.S, Handford, P.A.
登録日2014-04-25
公開日2014-05-21
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Fringe-Mediated Extension of O-Linked Fucose in the Ligand-Binding Region of Notch1 Increases Binding to Mammalian Notch Ligands.
Proc.Natl.Acad.Sci.USA, 111, 2014
4CUE
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BU of 4cue by Molmil
Human Notch1 EGF domains 11-13 mutant T466V
分子名称: CALCIUM ION, NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
著者Taylor, P, Takeuchi, H, Sheppard, D, Chillakuri, C, Lea, S.M, Haltiwanger, R.S, Handford, P.A.
登録日2014-03-18
公開日2014-05-21
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Fringe-Mediated Extension of O-Linked Fucose in the Ligand-Binding Region of Notch1 Increases Binding to Mammalian Notch Ligands.
Proc.Natl.Acad.Sci.USA, 111, 2014
2BOX
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BU of 2box by Molmil
EGF Domains 1,2,5 of human EMR2, a 7-TM immune system molecule, in complex with strontium.
分子名称: CACODYLATE ION, CHLORIDE ION, EGF-LIKE MODULE CONTAINING MUCIN-LIKE HORMONE RECEPTOR-LIKE 2 PRECURSOR, ...
著者Abbott, R.J.M, Spendlove, I, Roversi, P, Teriete, P, Knott, V, Handford, P.A, McDonnell, J.M, Lea, S.M.
登録日2005-04-14
公開日2006-10-18
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural and Functional Characterization of a Novel T Cell Receptor Co-Regulatory Protein Complex, Cd97-Cd55.
J.Biol.Chem., 282, 2007
2BO2
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BU of 2bo2 by Molmil
EGF Domains 1,2,5 of human EMR2, a 7-TM immune system molecule, in complex with calcium.
分子名称: CACODYLATE ION, CALCIUM ION, EGF-LIKE MODULE CONTAINING MUCIN-LIKE HORMONE RECEPTOR-LIKE 2 PRECURSOR
著者Abbott, R.J.M, Spendlove, I, Roversi, P, Teriete, P, Knott, V, Handford, P.A, McDonnell, J.M, Lea, S.M.
登録日2005-04-07
公開日2006-08-09
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural and Functional Characterization of a Novel T Cell Receptor Co-Regulatory Protein Complex, Cd97-Cd55.
J.Biol.Chem., 282, 2007
5AM7
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FGFR1 mutant with an inhibitor
分子名称: 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one, CHLORIDE ION, FIBROBLAST GROWTH FACTOR RECEPTOR 1
著者Bunney, T.D, Wan, S, Thiyagarajan, N, Sutto, L, Williams, S.V, Ashford, P, Koss, H, Knowles, M.A, Gervasio, F.L, Coveney, P.V, Katan, M.
登録日2015-03-10
公開日2015-03-18
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.957 Å)
主引用文献The Effect of Mutations on Drug Sensitivity and Kinase Activity of Fibroblast Growth Factor Receptors: A Combined Experimental and Theoretical Study
Ebiomedicine, 2, 2015

 

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