5MRO
| Arabidopsis thaliana IspD Glu258Ala mutant in complex with Azolopyrimidine (1) | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic, ... | 著者 | Schwab, A, Illarionov, B, Frank, A, Kunfermann, A, Seet, M, Bacher, A, Witschel, M, Fischer, M, Groll, M, Diederich, F. | 登録日 | 2016-12-23 | 公開日 | 2017-07-19 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Mechanism of Allosteric Inhibition of the Enzyme IspD by Three Different Classes of Ligands. ACS Chem. Biol., 12, 2017
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5MRP
| Arabidopsis thaliana IspD Glu258Ala mutant in complex with Azolopyrimidine (2) | 分子名称: | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic, 5-chloro-7-hydroxy-6-(phenylmethyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile, ... | 著者 | Schwab, A, Illarionov, B, Frank, A, Kunfermann, A, Seet, M, Bacher, A, Witschel, M, Fischer, M, Groll, M, Diederich, F. | 登録日 | 2016-12-23 | 公開日 | 2017-07-19 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Mechanism of Allosteric Inhibition of the Enzyme IspD by Three Different Classes of Ligands. ACS Chem. Biol., 12, 2017
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3DDY
| Structure of lumazine protein, an optical transponder of luminescent bacteria | 分子名称: | Lumazine protein, RIBOFLAVIN | 著者 | Chatwell, L, Illarionova, V, Illarionov, B, Skerra, A, Bacher, A, Fischer, M. | 登録日 | 2008-06-07 | 公開日 | 2008-07-01 | 最終更新日 | 2021-11-10 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure of lumazine protein, an optical transponder of luminescent bacteria. J.Mol.Biol., 382, 2008
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1SEP
| MOUSE SEPIAPTERIN REDUCTASE COMPLEXED WITH NADP AND SEPIAPTERIN | 分子名称: | BIOPTERIN, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SEPIAPTERIN REDUCTASE | 著者 | Auerbach, G, Herrmann, A, Guetlich, M, Fischer, M, Jacob, U, Bacher, A, Huber, R. | 登録日 | 1997-05-23 | 公開日 | 1999-01-13 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | The 1.25 A crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters. EMBO J., 16, 1997
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7M2E
| Crystal structure of BPTF bromodomain in complex with CB02-092 | 分子名称: | 4-chloro-5-{4-[2-(dimethylamino)ethyl]anilino}-2-methylpyridazin-3(2H)-one, Nucleosome-remodeling factor subunit BPTF | 著者 | Nithianantham, S, Fischer, M. | 登録日 | 2021-03-16 | 公開日 | 2022-02-16 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition J.Med.Chem., 64, 2021
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1R2K
| Crystal structure of MoaB from Escherichia coli | 分子名称: | Molybdenum cofactor biosynthesis protein B, SULFATE ION | 著者 | Bader, G, Gomez-Ortiz, M, Haussmann, C, Bacher, A, Huber, R, Fischer, M. | 登録日 | 2003-09-28 | 公開日 | 2004-06-01 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure of the molybdenum-cofactor biosynthesis protein MoaB of Escherichia coli. Acta Crystallogr.,Sect.D, 60, 2004
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1SQL
| Crystal structure of 7,8-dihydroneopterin aldolase in complex with guanine | 分子名称: | GUANINE, dihydroneopterin aldolase | 著者 | Bauer, S, Schott, A.K, Illarionova, V, Bacher, A, Huber, R, Fischer, M. | 登録日 | 2004-03-19 | 公開日 | 2004-06-08 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Biosynthesis of Tetrahydrofolate in Plants: Crystal Structure of 7,8-Dihydroneopterin Aldolase from Arabidopsis thaliana Reveals a Novel Adolase Class. J.Mol.Biol., 339, 2004
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1Z4A
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2AZN
| X-RAY Structure of 2,5-diamino-6-ribosylamino-4(3h)-pyrimidinone 5-phosphate reductase | 分子名称: | 2-(6-(2-CYCLOHEXYLETHOXY)-TETRAHYDRO-4,5-DIHYDROXY-2(HYDROXYMETHYL)-2H-PYRAN-3-YLOXY)-TETRAHYDRO-6(HYDROXYMETHYL)-2H-PYRAN-3,4,5-TRIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Chatwell, L, Bacher, A, Huber, R, Fischer, M, Krojer, T. | 登録日 | 2005-09-12 | 公開日 | 2006-08-29 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Biosynthesis of riboflavin: structure and properties of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase of Methanocaldococcus jannaschii J.Mol.Biol., 359, 2006
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2F59
| Lumazine synthase RibH1 from Brucella abortus (Gene BruAb1_0785, Swiss-Prot entry Q57DY1) complexed with inhibitor 5-Nitro-6-(D-Ribitylamino)-2,4(1H,3H) Pyrimidinedione | 分子名称: | 5-NITRO-6-RIBITYL-AMINO-2,4(1H,3H)-PYRIMIDINEDIONE, 6,7-dimethyl-8-ribityllumazine synthase 1, CALCIUM ION | 著者 | Klinke, S, Zylberman, V, Bonomi, H.R, Haase, I, Guimaraes, B.G, Braden, B.C, Bacher, A, Fischer, M, Goldbaum, F.A. | 登録日 | 2005-11-25 | 公開日 | 2006-11-28 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural and Kinetic Properties of Lumazine Synthase Isoenzymes in the Order Rhizobiales J.Mol.Biol., 373, 2007
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1JG5
| CRYSTAL STRUCTURE OF RAT GTP CYCLOHYDROLASE I FEEDBACK REGULATORY PROTEIN, GFRP | 分子名称: | GTP CYCLOHYDROLASE I FEEDBACK REGULATORY PROTEIN, POTASSIUM ION | 著者 | Bader, G, Schiffmann, S, Herrmann, A, Fischer, M, Gutlich, M, Auerbach, G, Ploom, T, Bacher, A, Huber, R, Lemm, T. | 登録日 | 2001-06-23 | 公開日 | 2001-10-10 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structure of rat GTP cyclohydrolase I feedback regulatory protein, GFRP. J.Mol.Biol., 312, 2001
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1KZ6
| Mutant enzyme W63Y/L119F Lumazine Synthase from S.pombe | 分子名称: | 6,7-Dimethyl-8-ribityllumazine Synthase, PHOSPHATE ION | 著者 | Gerhardt, S, Haase, I, Steinbacher, S, Kaiser, J.T, Cushman, M, Bacher, A, Huber, R, Fischer, M. | 登録日 | 2002-02-06 | 公開日 | 2002-07-24 | 最終更新日 | 2021-11-10 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | The structural basis of riboflavin binding to Schizosaccharomyces pombe 6,7-dimethyl-8-ribityllumazine synthase. J.Mol.Biol., 318, 2002
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1KYY
| Lumazine Synthase from S.pombe bound to nitropyrimidinedione | 分子名称: | 5-NITRO-6-RIBITYL-AMINO-2,4(1H,3H)-PYRIMIDINEDIONE, 6,7-Dimethyl-8-ribityllumazine Synthase, PHOSPHATE ION | 著者 | Gerhardt, S, Haase, I, Steinbacher, S, Kaiser, J.T, Cushman, M, Bacher, A, Huber, R, Fischer, M. | 登録日 | 2002-02-06 | 公開日 | 2002-07-24 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | The structural basis of riboflavin binding to Schizosaccharomyces pombe 6,7-dimethyl-8-ribityllumazine synthase. J.Mol.Biol., 318, 2002
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1KZ9
| Mutant Enzyme L119F Lumazine Synthase from S.pombe | 分子名称: | 6,7-Dimethyl-8-ribityllumazine Synthase, PHOSPHATE ION | 著者 | Gerhardt, S, Haase, I, Steinbacher, S, Kaiser, J.T, Cushman, M, Bacher, A, Huber, R, Fischer, M. | 登録日 | 2002-02-06 | 公開日 | 2002-07-24 | 最終更新日 | 2021-11-10 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | The structural basis of riboflavin binding to Schizosaccharomyces pombe 6,7-dimethyl-8-ribityllumazine synthase. J.Mol.Biol., 318, 2002
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1KYX
| Lumazine Synthase from S.pombe bound to carboxyethyllumazine | 分子名称: | 3-[8-((2S,3S,4R)-2,3,4,5-TETRAHYDROXYPENTYL)-2,4,7-TRIOXO-1,3,8-TRIHYDROPTERIDIN-6-YL]PROPANOIC ACID, 6,7-Dimethyl-8-ribityllumazine Synthase, PHOSPHATE ION | 著者 | Gerhardt, S, Haase, I, Steinbacher, S, Kaiser, J.T, Cushman, M, Bacher, A, Huber, R, Fischer, M. | 登録日 | 2002-02-06 | 公開日 | 2002-07-24 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | The structural basis of riboflavin binding to Schizosaccharomyces pombe 6,7-dimethyl-8-ribityllumazine synthase. J.Mol.Biol., 318, 2002
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1KZ4
| Mutant enzyme W63Y Lumazine Synthase from S.pombe | 分子名称: | 6,7-Dimethyl-8-ribityllumazine Synthase, PHOSPHATE ION | 著者 | Gerhardt, S, Haase, I, Steinbacher, S, Kaiser, J.T, Cushman, M, Bacher, A, Huber, R, Fischer, M. | 登録日 | 2002-02-06 | 公開日 | 2002-07-24 | 最終更新日 | 2021-11-10 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | The structural basis of riboflavin binding to Schizosaccharomyces pombe 6,7-dimethyl-8-ribityllumazine synthase. J.Mol.Biol., 318, 2002
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1KYV
| Lumazine Synthase from S.pombe bound to riboflavin | 分子名称: | 6,7-Dimethyl-8-ribityllumazine Synthase, PHOSPHATE ION, RIBOFLAVIN | 著者 | Gerhardt, S, Haase, I, Steinbacher, S, Kaiser, J.T, Cushman, M, Bacher, A, Huber, R, Fischer, M. | 登録日 | 2002-02-06 | 公開日 | 2002-07-24 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | The structural basis of riboflavin binding to Schizosaccharomyces pombe 6,7-dimethyl-8-ribityllumazine synthase. J.Mol.Biol., 318, 2002
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1NQV
| Crystal Structure of Lumazine Synthase from Aquifex aeolicus in Complex with Inhibitor: 5-nitroso-6-ribityl-amino-2,4(1H,3H)pyrimidinedione | 分子名称: | 5-NITROSO-6-RIBITYL-AMINO-2,4(1H,3H)-PYRIMIDINEDIONE, 6,7-dimethyl-8-ribityllumazine synthase, PHOSPHATE ION | 著者 | Zhang, X, Meining, W, Cushman, M, Haase, I, Fischer, M, Bacher, A, Ladenstein, R. | 登録日 | 2003-01-23 | 公開日 | 2004-01-23 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | A structure-based model of the reaction catalyzed by lumazine synthase from Aquifex aeolicus. J.Mol.Biol., 328, 2003
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1NQW
| Crystal Structure of Lumazine Synthase from Aquifex aeolicus in Complex with Inhibitor: 5-(6-D-ribitylamino-2,4(1H,3H)pyrimidinedione-5-yl)-1-pentyl-phosphonic acid | 分子名称: | 5-(6-D-RIBITYLAMINO-2,4(1H,3H)PYRIMIDINEDIONE-5-YL) PENTYL-1-PHOSPHONIC ACID, 6,7-dimethyl-8-ribityllumazine synthase | 著者 | Zhang, X, Meining, W, Cushman, M, Haase, I, Fischer, M, Bacher, A, Ladenstein, R. | 登録日 | 2003-01-23 | 公開日 | 2004-01-23 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | A structure-based model of the reaction catalyzed by lumazine synthase from Aquifex aeolicus. J.Mol.Biol., 328, 2003
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1NQX
| Crystal Structure of Lumazine Synthase from Aquifex aeolicus in Complex with Inhibitor: 3-(7-hydroxy-8-ribityllumazine-6-yl)propionic acid | 分子名称: | 3-(7-HYDROXY-8-RIBITYLLUMAZINE-6-YL) PROPIONIC ACID, 6,7-dimethyl-8-ribityllumazine synthase, PHOSPHATE ION | 著者 | Zhang, X, Meining, W, Cushman, M, Haase, I, Fischer, M, Bacher, A, Ladenstein, R. | 登録日 | 2003-01-23 | 公開日 | 2004-01-23 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | A structure-based model of the reaction catalyzed by lumazine synthase from Aquifex aeolicus. J.Mol.Biol., 328, 2003
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1NQU
| Crystal Structure of Lumazine Synthase from Aquifex aeolicus in Complex with Inhibitor: 6,7-dioxo-5H-8-ribitylaminolumazine | 分子名称: | 6,7-DIOXO-5H-8-RIBITYLAMINOLUMAZINE, 6,7-dimethyl-8-ribityllumazine synthase, PHOSPHATE ION | 著者 | Zhang, X, Meining, W, Cushman, M, Haase, I, Fischer, M, Bacher, A, Ladenstein, R. | 登録日 | 2003-01-23 | 公開日 | 2004-01-23 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | A structure-based model of the reaction catalyzed by lumazine synthase from Aquifex aeolicus. J.Mol.Biol., 328, 2003
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1KZ1
| Mutant enzyme W27G Lumazine Synthase from S.pombe | 分子名称: | 6,7-Dimethyl-8-ribityllumazine Synthase | 著者 | Gerhardt, S, Haase, I, Steinbacher, S, Kaiser, J.T, Cushman, M, Bacher, A, Huber, R, Fischer, M. | 登録日 | 2002-02-06 | 公開日 | 2002-07-24 | 最終更新日 | 2021-11-10 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The structural basis of riboflavin binding to Schizosaccharomyces pombe 6,7-dimethyl-8-ribityllumazine synthase. J.Mol.Biol., 318, 2002
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1KZL
| Riboflavin Synthase from S.pombe bound to Carboxyethyllumazine | 分子名称: | 3-[8-((2S,3S,4R)-2,3,4,5-TETRAHYDROXYPENTYL)-2,4,7-TRIOXO-1,3,8-TRIHYDROPTERIDIN-6-YL]PROPANOIC ACID, MERCURY (II) ION, Riboflavin Synthase | 著者 | Gerhardt, S, Schott, A.K, Kairies, N, Cushman, M, Illarionov, B, Eisenreich, W, Bacher, A, Huber, R, Steinbacher, S, Fischer, M. | 登録日 | 2002-02-07 | 公開日 | 2002-11-06 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Studies on the Reaction Mechanism of Riboflavin Synthase; X-Ray Crystal Structure of a Complex with 6-Carboxyethyl-7-Oxo-8-Ribityllumazine STRUCTURE, 10, 2002
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1N3R
| Biosynthesis of pteridins. Reaction mechanism of GTP cyclohydrolase I | 分子名称: | GTP cyclohydrolase I, GUANOSINE-5'-TRIPHOSPHATE | 著者 | Rebelo, J, Auerbach, G, Bader, G, Bracher, A, Nar, H, Hoesl, C, Schramek, N, Kaiser, J, Bacher, A, Huber, R, Fischer, M. | 登録日 | 2002-10-29 | 公開日 | 2003-10-14 | 最終更新日 | 2021-11-10 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Biosynthesis of Pteridines. Reaction Mechanism of GTP Cyclohydrolase I J.MOL.BIOL., 326, 2003
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1N3T
| Biosynthesis of pteridins. Reaction mechanism of GTP cyclohydrolase I | 分子名称: | GTP cyclohydrolase I, GUANOSINE-5'-TRIPHOSPHATE | 著者 | Rebelo, J, Auerbach, G, Bader, G, Bracher, A, Nar, H, Hoesl, C, Schramek, N, Kaiser, J, Bacher, A, Huber, R, Fischer, M. | 登録日 | 2002-10-29 | 公開日 | 2003-10-14 | 最終更新日 | 2021-11-10 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Biosynthesis of Pteridines. Reaction Mechanism of GTP Cyclohydrolase I J.MOL.BIOL., 326, 2003
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