1NQW

Crystal Structure of Lumazine Synthase from Aquifex aeolicus in Complex with Inhibitor: 5-(6-D-ribitylamino-2,4(1H,3H)pyrimidinedione-5-yl)-1-pentyl-phosphonic acid

Summary for 1NQW

• Entry DOI: 10.2210/pdb1nqw/pdb
• Related: 1NQU 1NQV 1NQX
• Descriptor: 6,7-dimethyl-8-ribityllumazine synthase, 5-(6-D-RIBITYLAMINO-2,4(1H,3H)PYRIMIDINEDIONE-5-YL) PENTYL-1-PHOSPHONIC ACID (3 entities in total)
• Functional Keywords: lumazine synthase, aquifex aeolicus, inhibitor complex, vitamin biosynthesis, catalytic mechanism, transferase
• Biological source: Aquifex aeolicus
• Total number of polymer chains: 5
• Total formula weight: 85692.73

Authors

Zhang, X.,Meining, W.,Cushman, M.,Haase, I.,Fischer, M.,Bacher, A.,Ladenstein, R. (deposition date: 2003-01-23, release date: 2004-01-23, Last modification date: 2024-02-14)

• Primary citation: Zhang, X.,Meining, W.,Cushman, M.,Haase, I.,Fischer, M.,Bacher, A.,Ladenstein, R.; A structure-based model of the reaction catalyzed by lumazine synthase from Aquifex aeolicus.; J.Mol.Biol., 328:167-182, 2003; PubMed: 12684006; DOI: 10.1016/S0022-2836(03)00186-4

Experimental method

X-RAY DIFFRACTION (2.2 Å)