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PDB: 124 件
1TSV
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THYMIDYLATE SYNTHASE R179A MUTANT
分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE
著者Finer-Moore, J, Stroud, R.M.
登録日1995-12-05
公開日1996-03-08
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase.
Protein Eng., 9, 1996
1TSZ
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THYMIDYLATE SYNTHASE R179K MUTANT
分子名称: PHOSPHATE ION, THYMIDYLATE SYNTHASE
著者Finer-Moore, J, Stroud, R.M.
登録日1995-12-05
公開日1996-03-08
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase.
Protein Eng., 9, 1996
1TSW
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THYMIDYLATE SYNTHASE R179A MUTANT
分子名称: PHOSPHATE ION, THYMIDYLATE SYNTHASE
著者Finer-Moore, J, Stroud, R.M.
登録日1995-12-05
公開日1996-03-08
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Contribution of a salt bridge to binding affinity and dUMP orientation to catalytic rate: mutation of a substrate-binding arginine in thymidylate synthase.
Protein Eng., 9, 1996
1THY
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REFINED STRUCTURES OF SUBSTRATE-BOUND AND PHOSPHATE-BOUND THYMIDYLATE SYNTHASE FROM LACTOBACILLUS CASEI
分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE
著者Finer-Moore, J, Stroud, R.
登録日1993-04-02
公開日1993-10-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei.
J.Mol.Biol., 232, 1993
1TIS
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CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE FROM T4 PHAGE
分子名称: PHOSPHATE ION, THYMIDYLATE SYNTHASE
著者Finer-Moore, J, Stroud, R.
登録日1994-01-24
公開日1994-04-30
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal structure of thymidylate synthase from T4 phage: component of a deoxynucleoside triphosphate-synthesizing complex.
Biochemistry, 33, 1994
5CD1
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Structure of an asymmetric tetramer of human tRNA m1A58 methyltransferase in a complex with SAH and tRNA3Lys
分子名称: S-ADENOSYL-L-HOMOCYSTEINE, SODIUM ION, tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A, ...
著者Finer-Moore, J, Czudnochowski, N, O'Connell III, J.D, Wang, A.L, Stroud, R.M.
登録日2015-07-02
公開日2015-11-04
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA3(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target.
J.Mol.Biol., 427, 2015
5CCX
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Structure of the product complex of tRNA m1A58 methyltransferase with tRNA3Lys as substrate
分子名称: S-ADENOSYL-L-HOMOCYSTEINE, SODIUM ION, tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A, ...
著者Finer-Moore, J, Czudnochowski, N, O'Connell III, J.D, Wang, A.L, Stroud, R.M.
登録日2015-07-02
公開日2015-11-04
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA3(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target.
J.Mol.Biol., 427, 2015
5CCB
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Crystal structure of human m1A58 methyltransferase in a complex with tRNA3Lys and SAH
分子名称: S-ADENOSYL-L-HOMOCYSTEINE, SODIUM ION, tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A, ...
著者Finer-Moore, J, Czudnochowski, N, O'Connell III, J.D, Wang, A.L, Stroud, R.M.
登録日2015-07-01
公開日2015-11-04
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA3(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target.
J.Mol.Biol., 427, 2015
1SJS
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ACCESS TO PHOSPHORYLATION IN ISOCITRATE DEHYDROGENASE MAY OCCUR BY DOMAIN SHIFTING
分子名称: ISOCITRATE DEHYDROGENASE
著者Finer-Moore, J, Stroud, R.M.
登録日1997-07-08
公開日1997-12-03
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献Access to phosphorylation in isocitrate dehydrogenase may occur by domain shifting.
Biochemistry, 36, 1997
3BT7
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Structure of E. coli 5-Methyluridine Methyltransferase TrmA in complex with 19 nucleotide T-arm analogue
分子名称: RNA (5'-D(P*GP*CP*UP*GP*UP*GP*(5MU)P*UP*CP*GP*AP*UP*CP*CP*AP*CP*AP*GP*C)-3'), tRNA (uracil-5-)-methyltransferase
著者Alian, A, Stroud, R.M, Finer-Moore, J.
登録日2007-12-27
公開日2008-04-29
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.43 Å)
主引用文献Structure of a TrmA-RNA complex: A consensus RNA fold contributes to substrate selectivity and catalysis in m5U methyltransferases.
Proc.Natl.Acad.Sci.Usa, 105, 2008
8SBE
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Structure of the rat vesicular glutamate transporter 2 determined by single-particle Cryo-EM
分子名称: Vesicular glutamate transporter 2
著者Li, F, Finer-Moore, J, Eriksen, J, Cheng, Y, Edwards, R, Stroud, R.
登録日2023-04-03
公開日2023-05-03
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Ion transport and regulation in a synaptic vesicle glutamate transporter.
Science, 368, 2020
5PTP
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STRUCTURE OF HYDROLASE (SERINE PROTEINASE)
分子名称: BETA TRYPSIN, CALCIUM ION
著者Stroud, R.M, Finer-Moore, J.
登録日1997-03-31
公開日1997-07-07
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (1.34 Å)
主引用文献Solvent structure in crystals of trypsin determined by X-ray and neutron diffraction.
Proteins, 12, 1992
8FVZ
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PiPT Y150A
分子名称: CITRATE ANION, PHOSPHATE ION, Phosphate transporter
著者Gupta, M, Finer-Moore, J, Stroud, R.M.
登録日2023-01-20
公開日2024-01-03
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Roles of PiPT residues in phosphate binding and transport tested by mutagenesis
To be published
4E28
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Structure of human thymidylate synthase in inactive conformation with a novel non-peptidic inhibitor
分子名称: 2-{(2Z,5S)-4-hydroxy-2-[(2E)-(2-hydroxybenzylidene)hydrazinylidene]-2,5-dihydro-1,3-thiazol-5-yl}-N-[3-(trifluoromethyl)phenyl]acetamide, 2-{(5S)-2-[(2E)-2-(2-hydroxybenzylidene)hydrazinyl]-4-oxo-4,5-dihydro-1,3-thiazol-5-yl}-N-[3-(trifluoromethyl)phenyl]acetamide, SULFATE ION, ...
著者Tochowicz, A, Finer-Moore, J, Stroud, R.M, Costi, M.P.
登録日2012-03-07
公開日2012-11-14
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.302 Å)
主引用文献Inhibitor of ovarian cancer cells growth by virtual screening: a new thiazole derivative targeting human thymidylate synthase.
J.Med.Chem., 55, 2012
3R1F
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Crystal structure of a key regulator of virulence in Mycobacterium tuberculosis
分子名称: ESX-1 secretion-associated regulator EspR
著者Rosenberg, O.S, Dovey, C, Finer-Moore, J, Stroud, R.M, Cox, J.S.
登録日2011-03-10
公開日2011-08-03
最終更新日2011-08-31
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献EspR, a key regulator of Mycobacterium tuberculosis virulence, adopts a unique dimeric structure among helix-turn-helix proteins.
Proc.Natl.Acad.Sci.USA, 108, 2011
6C9W
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Crystal Structure of a ligand bound LacY/Nanobody Complex
分子名称: 4-nitrophenyl alpha-D-galactopyranoside, Lactose permease, Nanobody9047, ...
著者Kumar, H, Finer-Moore, J.S, Jiang, X, Smirnova, I, Kasho, V, Pardon, E, Steyaert, J, Kaback, H.R, Stroud, R.M.
登録日2018-01-29
公開日2018-08-15
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystal Structure of a ligand-bound LacY-Nanobody Complex.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
1BJG
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D221(169)N MUTANT DOES NOT PROMOTE OPENING OF THE COFACTOR IMIDAZOLIDINE RING
分子名称: 5,10-METHYLENE-6-HYDROFOLIC ACID, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, THYMIDYLATE SYNTHASE
著者Sage, C.R, Michelitsch, M.D, Finer-Moore, J, Stroud, R.M.
登録日1998-06-25
公開日1998-11-04
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine.
Biochemistry, 37, 1998
1BO7
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THYMIDYLATE SYNTHASE R179T MUTANT
分子名称: PROTEIN (THYMIDYLATE SYNTHASE), URIDINE-5'-MONOPHOSPHATE
著者Morse, R, Finer-Moore, J, Stroud, R.M.
登録日1998-08-10
公開日1998-08-19
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance".
Biochemistry, 39, 2000
1BPJ
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THYMIDYLATE SYNTHASE R178T, R179T DOUBLE MUTANT
分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, POTASSIUM ION, PROTEIN (THYMIDYLATE SYNTHASE)
著者Morse, R.J, Finer-Moore, J.S, Stroud, R.M.
登録日1998-08-11
公開日1998-08-19
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance".
Biochemistry, 39, 2000
6NNR
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high-resolution structure of wild-type E. coli thymidylate synthase
分子名称: 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-deoxy-5'-uridylic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
著者Stroud, R.M, Finer-Moore, J.
登録日2019-01-15
公開日2019-01-30
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.05 Å)
主引用文献Mg2+ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site.
J. Am. Chem. Soc., 135, 2013
6VBG
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Lactose permease complex with thiodigalactoside and nanobody 9043
分子名称: Galactoside permease, beta-D-galactopyranose-(1-1)-1-thio-beta-D-galactopyranose, nanobody 9043, ...
著者Kumar, H, Stroud, R.M, Kaback, H.R, Finer-Moore, J, Smirnova, I, Kasho, V, Pardon, E, Steyart, J.
登録日2019-12-18
公開日2020-11-25
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Diversity in kinetics correlated with structure in nano body-stabilized LacY.
Plos One, 15, 2020
1BTX
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Episelection: Novel Ki ~Nanomolar Inhibitors of Serine Proteases Selected by Binding or Chemistry on an Enzyme Surface
分子名称: BETA-TRYPSIN, CALCIUM ION, N-(tert-butoxycarbonyl)-L-alanyl-N-[(1S)-5-amino-1-(diethoxyboranyl)pentyl]-L-valinamide
著者Stroud, R.M, Katz, B.A, Finer-Moore, J.
登録日1995-05-17
公開日1995-10-15
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Episelection: novel Ki approximately nanomolar inhibitors of serine proteases selected by binding or chemistry on an enzyme surface.
Biochemistry, 34, 1995
7UK4
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KS-AT di-domain of mycobacterial Pks13 with endogenous KS ligand bound
分子名称: Polyketide synthase PKS13, UNKNOWN LIGAND
著者Kim, S.K, Dickinson, M.S, Finer-Moore, J.S, Rosenberg, O.S, Stroud, R.M.
登録日2022-03-31
公開日2023-02-15
最終更新日2023-03-29
実験手法ELECTRON MICROSCOPY (1.94 Å)
主引用文献Structure and dynamics of the essential endogenous mycobacterial polyketide synthase Pks13.
Nat.Struct.Mol.Biol., 30, 2023
3DH3
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Crystal Structure of RluF in complex with a 22 nucleotide RNA substrate
分子名称: Ribosomal large subunit pseudouridine synthase F, stem loop fragment of E. Coli 23S RNA
著者Alian, A, DeGiovanni, A, Stroud, R.M, Finer-Moore, J.S.
登録日2008-06-16
公開日2009-04-28
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystal structure of an RluF-RNA complex: a base-pair rearrangement is the key to selectivity of RluF for U2604 of the ribosome.
J.Mol.Biol., 388, 2009
7SP5
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Crystal Structure of a Eukaryotic Phosphate Transporter
分子名称: PHOSPHATE ION, Phosphate transporter, nonyl beta-D-glucopyranoside
著者Stroud, R.M, Pedersen, B.P, Kumar, H, Waight, A.B, Risenmay, A.J, Roe-Zurz, Z, Chau, B.H, Schlessinger, A, Bonomi, M, Harries, W, Sali, A, Johri, A.K, Finer-Moore, J.
登録日2021-11-02
公開日2021-11-17
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal structure of a eukaryotic phosphate transporter.
Nature, 496, 2013

223532

件を2024-08-07に公開中

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