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1BPJ

THYMIDYLATE SYNTHASE R178T, R179T DOUBLE MUTANT

Summary for 1BPJ
Entry DOI10.2210/pdb1bpj/pdb
DescriptorPROTEIN (THYMIDYLATE SYNTHASE), POTASSIUM ION, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ... (4 entities in total)
Functional Keywordstransferase (methyltransferase), transferase, methyltransferase, nucleotide biosynthesis
Biological sourceLactobacillus casei
Cellular locationCytoplasm: P00469
Total number of polymer chains1
Total formula weight36865.55
Authors
Morse, R.J.,Finer-Moore, J.S.,Stroud, R.M. (deposition date: 1998-08-11, release date: 1998-08-19, Last modification date: 2023-08-09)
Primary citationMorse, R.J.,Kawase, S.,Santi, D.V.,Finer-Moore, J.,Stroud, R.M.
Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance".
Biochemistry, 39:1011-1020, 2000
Cited by
PubMed: 10653645
DOI: 10.1021/bi9918590
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

217705

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