5CCX

Structure of the product complex of tRNA m1A58 methyltransferase with tRNA3Lys as substrate

Summary for 5CCX

• Entry DOI: 10.2210/pdb5ccx/pdb
• Related: 5CCB 5CD1
• Descriptor: tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A, tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6, tRNA3Lys, ... (6 entities in total)
• Functional Keywords: trna modification, sam-dependent methyltransferase class i, methyltransferase fold, hiv-1 primer, transferase-rna complex, transferase/rna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 112518.01

Authors

Finer-Moore, J.,Czudnochowski, N.,O'Connell III, J.D.,Wang, A.L.,Stroud, R.M. (deposition date: 2015-07-02, release date: 2015-11-04, Last modification date: 2023-09-27)

• Primary citation: Finer-Moore, J.,Czudnochowski, N.,O'Connell, J.D.,Wang, A.L.,Stroud, R.M.; Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA3(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target.; J.Mol.Biol., 427:3862-3876, 2015; PubMed: 26470919; DOI: 10.1016/j.jmb.2015.10.005

Experimental method

X-RAY DIFFRACTION (2.1 Å)