8A40
 
 | | Structure of mammalian Pol II-TFIIS elongation complex | | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ... | | Authors: | Farnung, L, Ochmann, M, Garg, G, Vos, S.M, Cramer, P. | | Deposit date: | 2022-06-09 | | Release date: | 2023-08-23 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structure of a backtracked hexasomal intermediate of nucleosome transcription.
Mol.Cell, 82, 2022
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8A3Y
 | | Structure of mammalian Pol II-DSIF-SPT6-PAF1-TFIIS-hexasome elongation complex | | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ... | | Authors: | Farnung, L, Ochmann, M, Garg, G, Vos, S.M, Cramer, P. | | Deposit date: | 2022-06-09 | | Release date: | 2024-07-31 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structure of a backtracked hexasomal intermediate of nucleosome transcription.
Mol.Cell, 82, 2022
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6I84
 | | Structure of transcribing RNA polymerase II-nucleosome complex | | Descriptor: | DNA (158-MER), DNA (170-MER), DNA-directed RNA polymerase II subunit RPB1, ... | | Authors: | Farnung, L, Vos, S.M, Cramer, P. | | Deposit date: | 2018-11-19 | | Release date: | 2019-01-02 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Structure of transcribing RNA polymerase II-nucleosome complex.
Nat Commun, 9, 2018
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6RYU
 | | Nucleosome-CHD4 complex structure (two CHD4 copies) | | Descriptor: | Chromodomain-helicase-DNA-binding protein 4,CHD4,Chromodomain-helicase-DNA-binding protein 4, DNA (149-MER), Histone H2A type 1, ... | | Authors: | Farnung, L, Ochmann, M, Cramer, P. | | Deposit date: | 2019-06-12 | | Release date: | 2020-07-15 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Nucleosome-CHD4 chromatin remodeller structure maps human disease mutations.
Elife, 9, 2020
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6RYR
 | | Nucleosome-CHD4 complex structure (single CHD4 copy) | | Descriptor: | Chromodomain-helicase-DNA-binding protein 4,Chromodomain-helicase-DNA-binding protein 4,Chromodomain-helicase-DNA-binding protein 4, DNA (149-MER), Histone H2A type 1, ... | | Authors: | Farnung, L, Ochmann, M, Cramer, P. | | Deposit date: | 2019-06-11 | | Release date: | 2020-07-15 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Nucleosome-CHD4 chromatin remodeller structure maps human disease mutations.
Elife, 9, 2020
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7NKY
 | | RNA Polymerase II-Spt4/5-nucleosome-FACT structure | | Descriptor: | Chromatin elongation factor SPT4, DNA (138-MER), DNA (148-MER), ... | | Authors: | Farnung, L, Ochmann, M, Engeholm, M, Cramer, P. | | Deposit date: | 2021-02-19 | | Release date: | 2021-07-07 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural basis of nucleosome transcription mediated by Chd1 and FACT.
Nat.Struct.Mol.Biol., 28, 2021
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7NKX
 | | RNA polymerase II-Spt4/5-nucleosome-Chd1 structure | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Chromatin elongation factor SPT4, ... | | Authors: | Farnung, L, Ochmann, M, Engeholm, M, Cramer, P. | | Deposit date: | 2021-02-19 | | Release date: | 2021-08-25 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural basis of nucleosome transcription mediated by Chd1 and FACT.
Nat.Struct.Mol.Biol., 28, 2021
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5O9G
 | | Structure of nucleosome-Chd1 complex | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Chromo domain-containing protein 1, ... | | Authors: | Farnung, L, Vos, S.M, Wigge, C, Cramer, P. | | Deposit date: | 2017-06-19 | | Release date: | 2017-10-11 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (4.8 Å) | | Cite: | Nucleosome-Chd1 structure and implications for chromatin remodelling.
Nature, 550, 2017
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8F86
 | | SIRT6 bound to an H3K9Ac nucleosome | | Descriptor: | DNA (148-MER), Histone H2A type 1, Histone H2B, ... | | Authors: | Markert, J, Whedon, S, Wang, Z, Cole, P, Farnung, L. | | Deposit date: | 2022-11-21 | | Release date: | 2023-04-05 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural Basis of Sirtuin 6-Catalyzed Nucleosome Deacetylation.
J.Am.Chem.Soc., 145, 2023
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8TOF
 | | Rpd3S bound to an H3K36Cme3 modified nucleosome | | Descriptor: | Chromatin modification-related protein EAF3, DNA (176-MER), Histone H2A, ... | | Authors: | Markert, J.W, Vos, S.M, Farnung, L. | | Deposit date: | 2023-08-03 | | Release date: | 2024-01-17 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Structure of the complete Saccharomyces cerevisiae Rpd3S-nucleosome complex.
Nat Commun, 14, 2023
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9BZ0
 | | Structure of an STK19-containing TC-NER complex | | Descriptor: | DET1- and DDB1-associated protein 1, DNA (35-MER), DNA (49-MER), ... | | Authors: | Mevissen, T.E.T, Kuemmecke, M, Farnung, L, Walter, J.C. | | Deposit date: | 2024-05-24 | | Release date: | 2024-12-25 | | Last modified: | 2025-01-15 | | Method: | ELECTRON MICROSCOPY (1.9 Å) | | Cite: | STK19 positions TFIIH for cell-free transcription-coupled DNA repair.
Cell, 187, 2024
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9EGZ
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9EGY
 | | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-nucleosome, bp +27 | | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB3, DNA-directed RNA polymerase II subunit RPB7, ... | | Authors: | Markert, J, Farnung, L. | | Deposit date: | 2024-11-21 | | Release date: | 2024-12-18 | | Last modified: | 2025-02-12 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural basis of H3K36 trimethylation by SETD2 during chromatin transcription.
Science, 387, 2025
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9EGX
 | | RNA polymerase II-DSIF-SPT6-PAF1c-TFIIS-IWS1-hexasome, bp +27 | | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB3, DNA-directed RNA polymerase II subunit RPB7, ... | | Authors: | Markert, J, Farnung, L. | | Deposit date: | 2024-11-21 | | Release date: | 2024-12-18 | | Last modified: | 2025-02-12 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural basis of H3K36 trimethylation by SETD2 during chromatin transcription.
Science, 387, 2025
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9EH2
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9EH1
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9EH0
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6YYT
 | | Structure of replicating SARS-CoV-2 polymerase | | Descriptor: | RNA product, ZINC ION, nsp12, ... | | Authors: | Hillen, H.S, Kokic, G, Farnung, L, Dienemann, C, Tegunov, D, Cramer, P. | | Deposit date: | 2020-05-06 | | Release date: | 2020-05-13 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structure of replicating SARS-CoV-2 polymerase.
Nature, 584, 2020
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7UND
 | | Pol II-DSIF-SPT6-PAF1c-TFIIS-nucleosome complex (stalled at +38) | | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB3, DNA-directed RNA polymerase II subunit RPB7, ... | | Authors: | Filipovski, M, Vos, S.M, Farnung, L. | | Deposit date: | 2022-04-10 | | Release date: | 2022-10-19 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural basis of nucleosome retention during transcription elongation.
Science, 376, 2022
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7UNC
 | | Pol II-DSIF-SPT6-PAF1c-TFIIS complex with rewrapped nucleosome | | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB3, DNA-directed RNA polymerase II subunit RPB7, ... | | Authors: | Filipovski, M, Vos, S.M, Farnung, L. | | Deposit date: | 2022-04-10 | | Release date: | 2022-10-19 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural basis of nucleosome retention during transcription elongation.
Science, 376, 2022
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6TED
 | | Structure of complete, activated transcription complex Pol II-DSIF-PAF-SPT6 uncovers allosteric elongation activation by RTF1 | | Descriptor: | DNA (37-MER), DNA-directed RNA polymerase II subunit RPB9, DNA-directed RNA polymerase subunit, ... | | Authors: | Vos, S.M, Farnung, L, Cramer, P. | | Deposit date: | 2019-11-11 | | Release date: | 2020-07-22 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structure of complete Pol II-DSIF-PAF-SPT6 transcription complex reveals RTF1 allosteric activation.
Nat.Struct.Mol.Biol., 27, 2020
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6EXV
 | | Structure of mammalian RNA polymerase II elongation complex inhibited by Alpha-amanitin | | Descriptor: | AMATOXIN, DNA (25-MER), DNA (36-MER), ... | | Authors: | Liu, X, Farnung, L, Wigge, C, Cramer, P. | | Deposit date: | 2017-11-09 | | Release date: | 2018-03-21 | | Last modified: | 2025-04-09 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Cryo-EM structure of a mammalian RNA polymerase II elongation complex inhibited by alpha-amanitin.
J. Biol. Chem., 293, 2018
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4NST
 | | Crystal structure of human Cdk12/Cyclin K in complex with ADP-aluminum fluoride | | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, ... | | Authors: | Boesken, C.A, Farnung, L, Anand, K, Geyer, M. | | Deposit date: | 2013-11-29 | | Release date: | 2014-03-26 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The structure and substrate specificity of human Cdk12/Cyclin K.
Nat Commun, 5, 2014
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6S01
 | | Structure of LEDGF PWWP domain bound H3K36 methylated nucleosome | | Descriptor: | Histone H2A, Histone H2B 1.1, Histone H3, ... | | Authors: | Wang, H, Farnung, L, Dienemann, C, Cramer, P. | | Deposit date: | 2019-06-13 | | Release date: | 2019-12-18 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structure of H3K36-methylated nucleosome-PWWP complex reveals multivalent cross-gyre binding.
Nat.Struct.Mol.Biol., 27, 2020
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5OT2
 | | RNA polymerase II elongation complex in the presence of 3d-Napht-A | | Descriptor: | 2-ethyl-7-methoxy-naphthalene, DNA non-template strand, DNA template strand, ... | | Authors: | Malvezzi, S, Farnung, L, Aloisi, C, Angelov, T, Cramer, P, Sturla, S.J. | | Deposit date: | 2017-08-19 | | Release date: | 2017-11-01 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Mechanism of RNA polymerase II stalling by DNA alkylation.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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