8RJ9
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![BU of 8rj9 by Molmil](/molmil-images/mine/8rj9) | E. coli adenylate kinase Asp84Ala variant in complex with two ADP molecules as a result of enzymatic AP4A hydrolysis. | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Adenylate kinase | Authors: | Tischlik, S, Ronge, P, Wolf-Watz, M, Sauer-Eriksson, A.E. | Deposit date: | 2023-12-20 | Release date: | 2024-07-10 | Last modified: | 2024-08-28 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Magnesium induced structural reorganization in the active site of adenylate kinase. Sci Adv, 10, 2024
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7OB4
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2G2P
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![BU of 2g2p by Molmil](/molmil-images/mine/2g2p) | Crystal Structure of E.coli transthyretin-related protein with bound Zn and Br | Descriptor: | BROMIDE ION, SULFATE ION, Transthyretin-like protein, ... | Authors: | Lundberg, E, Backstrom, S, Sauer, U.H, Sauer-Eriksson, A.E. | Deposit date: | 2006-02-16 | Release date: | 2006-12-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The transthyretin-related protein: structural investigation of a novel protein family J.Struct.Biol., 155, 2006
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2G2N
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![BU of 2g2n by Molmil](/molmil-images/mine/2g2n) | Crystal Structure of E.coli transthyretin-related protein with bound Zn | Descriptor: | SULFATE ION, Transthyretin-like protein, ZINC ION | Authors: | Lundberg, E, Backstrom, S, Sauer, U.H, Sauer-Eriksson, A.E. | Deposit date: | 2006-02-16 | Release date: | 2006-12-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | The transthyretin-related protein: structural investigation of a novel protein family J.Struct.Biol., 155, 2006
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6ZJD
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![BU of 6zjd by Molmil](/molmil-images/mine/6zjd) | Crystal structure of human adenylate kinase 3, AK3, in complex with inhibitor ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, GTP:AMP phosphotransferase AK3, ... | Authors: | Grundstrom, C, Rogne, P, Wolf-Watz, M, Sauer-Eriksson, A.E. | Deposit date: | 2020-06-28 | Release date: | 2020-09-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural Basis for GTP versus ATP Selectivity in the NMP Kinase AK3. Biochemistry, 59, 2020
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6ZJB
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![BU of 6zjb by Molmil](/molmil-images/mine/6zjb) | Crystal structure of human adenylate kinase 3, AK3, in complex with inhibitor Gp5A | Descriptor: | GTP:AMP phosphotransferase AK3, mitochondrial, MAGNESIUM ION, ... | Authors: | Grundstrom, C, Rogne, P, Wolf-Watz, M, Sauer-Eriksson, A.E. | Deposit date: | 2020-06-28 | Release date: | 2020-09-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.822 Å) | Cite: | Structural Basis for GTP versus ATP Selectivity in the NMP Kinase AK3. Biochemistry, 59, 2020
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6ZJE
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![BU of 6zje by Molmil](/molmil-images/mine/6zje) | Crystal structure of human adenylate kinase 3, AK3, in complex with inhibitor Ap5A | Descriptor: | BIS(ADENOSINE)-5'-PENTAPHOSPHATE, CHLORIDE ION, GTP:AMP phosphotransferase AK3, ... | Authors: | Grundstrom, C, Rogne, P, Wolf-Watz, M, Sauer-Eriksson, A.E. | Deposit date: | 2020-06-28 | Release date: | 2020-09-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Structural Basis for GTP versus ATP Selectivity in the NMP Kinase AK3. Biochemistry, 59, 2020
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4QXV
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![BU of 4qxv by Molmil](/molmil-images/mine/4qxv) | CRYSTAL STRUCTURE of HUMAN TRANSTHYRETIN IN COMPLEX WITH LUTEOLIN AT 1.1 A RESOLUTION | Descriptor: | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one, GLYCEROL, SODIUM ION, ... | Authors: | Begum, A, Olofsson, A, Sauer-Eriksson, A.E. | Deposit date: | 2014-07-22 | Release date: | 2015-06-03 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.12 Å) | Cite: | The flavonoid luteolin, but not luteolin-7-o-glucoside, prevents a transthyretin mediated toxic response. Plos One, 10, 2015
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4QYA
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![BU of 4qya by Molmil](/molmil-images/mine/4qya) | Crystal structure of human transthyretin variant V30M in complex with luteolin | Descriptor: | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one, SODIUM ION, Transthyretin | Authors: | Begum, A, Olofsson, A, Sauer-Eriksson, A.E. | Deposit date: | 2014-07-24 | Release date: | 2015-06-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The flavonoid luteolin, but not luteolin-7-o-glucoside, prevents a transthyretin mediated toxic response. Plos One, 10, 2015
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5EJE
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![BU of 5eje by Molmil](/molmil-images/mine/5eje) | Crystal structure of E. coli Adenylate kinase G56C/T163C double mutant in complex with Ap5a | Descriptor: | Adenylate kinase, BIS(ADENOSINE)-5'-PENTAPHOSPHATE, COBALT (II) ION | Authors: | Sauer, U.H, Kovermann, M, Grundstrom, C, Wolf-Watz, M, Sauer-Eriksson, A.E. | Deposit date: | 2015-11-01 | Release date: | 2016-11-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for ligand binding to an enzyme by a conformational selection pathway. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5EN3
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![BU of 5en3 by Molmil](/molmil-images/mine/5en3) | Crystal structure of human transthyretin in complex with luteolin-Cl at 1.25 A resolution | Descriptor: | 2-[3,4-bis(oxidanyl)phenyl]-7-chloranyl-5-oxidanyl-chromen-4-one, GLYCEROL, SODIUM ION, ... | Authors: | Begum, A, Nilsson, L, Olofsson, A, Sauer-Eriksson, A.E. | Deposit date: | 2015-11-09 | Release date: | 2016-04-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Modifications of the 7-Hydroxyl Group of the Transthyretin Ligand Luteolin Provide Mechanistic Insights into Its Binding Properties and High Plasma Specificity. Plos One, 11, 2016
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5F1R
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![BU of 5f1r by Molmil](/molmil-images/mine/5f1r) | The Transcriptional Regulator PrfA from Listeria Monocytogenes in complex with a ring-fused 2-pyridone (C10) | Descriptor: | (3~{R})-8-cyclopropyl-7-(naphthalen-1-ylmethyl)-5-oxidanylidene-2,3-dihydro-[1,3]thiazolo[3,2-a]pyridine-3-carboxylic acid, Listeriolysin regulatory protein | Authors: | Begum, A, Grundstrom, C, Good, J.A.D, Andersson, C, ALmqvist, F, Johansson, J, Sauer, U.H, Sauer-Eriksson, A.E. | Deposit date: | 2015-11-30 | Release date: | 2016-03-16 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Attenuating Listeria monocytogenes Virulence by Targeting the Regulatory Protein PrfA. Cell Chem Biol, 23, 2016
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6S36
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![BU of 6s36 by Molmil](/molmil-images/mine/6s36) | Crystal structure of E. coli Adenylate kinase R119K mutant | Descriptor: | Adenylate kinase, CHLORIDE ION, MAGNESIUM ION, ... | Authors: | Grundstrom, C, Rogne, P, Wolf-Watz, M, Sauer-Eriksson, A.E. | Deposit date: | 2019-06-24 | Release date: | 2019-08-07 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Nucleation of an Activating Conformational Change by a Cation-pi Interaction. Biochemistry, 58, 2019
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6RZE
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![BU of 6rze by Molmil](/molmil-images/mine/6rze) | Crystal structure of E. coli Adenylate kinase R119A mutant | Descriptor: | Adenylate kinase, CHLORIDE ION, SODIUM ION | Authors: | Grundstrom, C, Rogne, P, Wolf-Watz, M, Sauer-Eriksson, A.E. | Deposit date: | 2019-06-13 | Release date: | 2019-08-07 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Nucleation of an Activating Conformational Change by a Cation-pi Interaction. Biochemistry, 58, 2019
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3UCM
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3UCK
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![BU of 3uck by Molmil](/molmil-images/mine/3uck) | Coccomyxa beta-carbonic anhydrase in complex with phosphate | Descriptor: | CHLORIDE ION, Carbonic anhydrase, PHOSPHATE ION, ... | Authors: | Huang, S, Hainzl, T, Sauer-Eriksson, A.E. | Deposit date: | 2011-10-27 | Release date: | 2011-11-23 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural studies of [beta]-carbonic anhydrase from the green alga Coccomyxa: inhibitor complexes with anions and acetazolamide. Plos One, 6, 2011
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3UCO
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3UCN
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![BU of 3ucn by Molmil](/molmil-images/mine/3ucn) | Coccomyxa beta-carbonic anhydrase in complex with azide | Descriptor: | AZIDE ION, CHLORIDE ION, Carbonic anhydrase, ... | Authors: | Huang, S, Hainzl, T, Sauer-Eriksson, A.E. | Deposit date: | 2011-10-27 | Release date: | 2011-11-23 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structural studies of [beta]-carbonic anhydrase from the green alga Coccomyxa: inhibitor complexes with anions and acetazolamide. Plos One, 6, 2011
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3UCJ
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![BU of 3ucj by Molmil](/molmil-images/mine/3ucj) | Coccomyxa beta-carbonic anhydrase in complex with acetazolamide | Descriptor: | 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, CHLORIDE ION, Carbonic anhydrase, ... | Authors: | Huang, S, Hainzl, T, Sauer-Eriksson, A.E. | Deposit date: | 2011-10-27 | Release date: | 2011-11-23 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural studies of [beta]-carbonic anhydrase from the green alga Coccomyxa: inhibitor complexes with anions and acetazolamide. Plos One, 6, 2011
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6QVZ
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![BU of 6qvz by Molmil](/molmil-images/mine/6qvz) | The Transcriptional Regulator PrfA-L140H mutant from Listeria Monocytogenes | Descriptor: | ISOPROPYL ALCOHOL, Listeriolysin positive regulatory factor A, SODIUM ION | Authors: | Hall, M, Grundstrom, C, Hansen, S, Brannstrom, K, Johansson, J, Sauer-Eriksson, A.E. | Deposit date: | 2019-03-05 | Release date: | 2020-04-01 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.705 Å) | Cite: | A Novel Growth-Based Selection Strategy Identifies New Constitutively Active Variants of the Major Virulence Regulator PrfA in Listeria monocytogenes. J.Bacteriol., 202, 2020
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6QWH
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![BU of 6qwh by Molmil](/molmil-images/mine/6qwh) | The Transcriptional Regulator PrfA-L140H mutant from Listeria Monocytogenes in complex with a 30-bp operator PrfA-box motif | Descriptor: | DNA (30-MER), GLYCEROL, Listeriolysin positive regulatory factor A | Authors: | Hall, M, Grundstrom, C, Hansen, S, Brannstrom, K, Johansson, J, Sauer-Eriksson, A.E. | Deposit date: | 2019-03-05 | Release date: | 2020-04-01 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | A Novel Growth-Based Selection Strategy Identifies New Constitutively Active Variants of the Major Virulence Regulator PrfA in Listeria monocytogenes. J.Bacteriol., 202, 2020
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6QWM
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![BU of 6qwm by Molmil](/molmil-images/mine/6qwm) | The Transcriptional Regulator PrfA-A218G mutant from Listeria Monocytogenes in complex with a 30-bp operator PrfA-box motif | Descriptor: | DNA (30-MER), GLYCEROL, Listeriolysin positive regulatory factor A | Authors: | Hall, M, Grundstrom, C, Hansen, S, Brannstrom, K, Johansson, J, Sauer-Eriksson, A.E. | Deposit date: | 2019-03-05 | Release date: | 2020-04-01 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | A Novel Growth-Based Selection Strategy Identifies New Constitutively Active Variants of the Major Virulence Regulator PrfA in Listeria monocytogenes. J.Bacteriol., 202, 2020
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6QW1
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![BU of 6qw1 by Molmil](/molmil-images/mine/6qw1) | The Transcriptional Regulator PrfA-L140F mutant from Listeria Monocytogenes | Descriptor: | ISOPROPYL ALCOHOL, Listeriolysin positive regulatory factor A, SODIUM ION | Authors: | Hall, M, Grundstrom, C, Hansen, S, Brannstrom, K, Johansson, J, Sauer-Eriksson, A.E. | Deposit date: | 2019-03-05 | Release date: | 2020-04-01 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.844 Å) | Cite: | A Novel Growth-Based Selection Strategy Identifies New Constitutively Active Variants of the Major Virulence Regulator PrfA in Listeria monocytogenes. J.Bacteriol., 202, 2020
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5JIQ
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![BU of 5jiq by Molmil](/molmil-images/mine/5jiq) | Crystal Structure of Human Transthyretin in Complex with 2,2',4,4'-tetrahydroxybenzophenone (BP2) | Descriptor: | GLYCEROL, SODIUM ION, Transthyretin, ... | Authors: | Begum, A, Zhang, J, Olofsson, A, Andersson, P, Sauer-Eriksson, A.E. | Deposit date: | 2016-04-22 | Release date: | 2016-10-05 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Structure-Based Virtual Screening Protocol for in Silico Identification of Potential Thyroid Disrupting Chemicals Targeting Transthyretin. Environ. Sci. Technol., 50, 2016
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5JID
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![BU of 5jid by Molmil](/molmil-images/mine/5jid) | Crystal Structure of Human Transthyretin in Complex with Perfluorooctanoic acid (PFOA) | Descriptor: | SODIUM ION, Transthyretin, pentadecafluorooctanoic acid | Authors: | Begum, A, Zhang, J, Olofsson, A, Andersson, P, Sauer-Eriksson, A.E. | Deposit date: | 2016-04-22 | Release date: | 2016-10-05 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Structure-Based Virtual Screening Protocol for in Silico Identification of Potential Thyroid Disrupting Chemicals Targeting Transthyretin. Environ. Sci. Technol., 50, 2016
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