7OB4

Cryo-EM structure of a twisted-dimer transthyretin amyloid fibril from vitreous body of the eye

Summary for 7OB4

• Entry DOI: 10.2210/pdb7ob4/pdb
• EMDB information: 12794
• Descriptor: Transthyretin (1 entity in total)
• Functional Keywords: amyloid fibril, transthyretin, misfolding, protein fibril, attr amyloidosis, v30m variant, ex vivo, vitreous body
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 14
• Total formula weight: 193331.96

Authors

Iakovleva, I.,Sauer-Eriksson, A.E. (deposition date: 2021-04-21, release date: 2021-12-15, Last modification date: 2022-02-16)

• Primary citation: Iakovleva, I.,Hall, M.,Oelker, M.,Sandblad, L.,Anan, I.,Sauer-Eriksson, A.E.; Structural basis for transthyretin amyloid formation in vitreous body of the eye.; Nat Commun, 12:7141-7141, 2021; PubMed: 34880242; DOI: 10.1038/s41467-021-27481-4

Experimental method

ELECTRON MICROSCOPY (3.22 Å)