5EN3

Crystal structure of human transthyretin in complex with luteolin-Cl at 1.25 A resolution

Summary for 5EN3

Entry DOI	10.2210/pdb5en3/pdb
Related	4qxv
Descriptor	Transthyretin, 2-[3,4-bis(oxidanyl)phenyl]-7-chloranyl-5-oxidanyl-chromen-4-one, SODIUM ION, ... (5 entities in total)
Functional Keywords	beta barrel, wild type human ttr, transthyretin, transport protein
Biological source	Homo sapiens (Human)
Cellular location	Secreted: P02766
Total number of polymer chains	2
Total formula weight	28279.17
Authors	Begum, A.,Nilsson, L.,Olofsson, A.,Sauer-Eriksson, A.E. (deposition date: 2015-11-09, release date: 2016-04-20, Last modification date: 2024-01-10)
Primary citation	Nilsson, L.,Larsson, A.,Begum, A.,Iakovleva, I.,Carlsson, M.,Brannstrom, K.,Sauer-Eriksson, A.E.,Olofsson, A. Modifications of the 7-Hydroxyl Group of the Transthyretin Ligand Luteolin Provide Mechanistic Insights into Its Binding Properties and High Plasma Specificity. Plos One, 11:e0153112-e0153112, 2016 Cited by PubMed: 27050398 DOI: 10.1371/journal.pone.0153112 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.25 Å)

Structure validation