6NB9
 
 | | Amyloid-Beta (20-34) with L-isoaspartate 23 | | 分子名称: | Amyloid-beta A4 protein | | 著者 | Sawaya, M.R, Warmack, R.A, Boyer, D.R, Zee, C.T, Richards, L.S, Cascio, D, Gonen, T, Clarke, S.G, Eisenberg, D.S. | | 登録日 | 2018-12-06 | | 公開日 | 2019-08-07 | | 最終更新日 | 2022-09-07 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.05 Å) | | 主引用文献 | Structure of amyloid-beta (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface.
Nat Commun, 10, 2019
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6OIZ
 | | Amyloid-Beta (20-34) wild type | | 分子名称: | Amyloid beta A4 protein | | 著者 | Sawaya, M.R, Warmack, R.A, Zee, C.T, Gonen, T, Clarke, S.G, Eisenberg, D.S. | | 登録日 | 2019-04-10 | | 公開日 | 2019-08-07 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.1 Å) | | 主引用文献 | Structure of amyloid-beta (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface.
Nat Commun, 10, 2019
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6PES
 | | Cryo-EM structure of alpha-synuclein H50Q Wide Fibril | | 分子名称: | Alpha-synuclein | | 著者 | Boyer, D.R, Li, B, Sawaya, M.R, Jiang, L, Eisenberg, D.S. | | 登録日 | 2019-06-20 | | 公開日 | 2019-11-27 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structures of fibrils formed by alpha-synuclein hereditary disease mutant H50Q reveal new polymorphs.
Nat.Struct.Mol.Biol., 26, 2019
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6PIL
 | | Antibody scFv-M204 monomeric state | | 分子名称: | CHLORIDE ION, scFv-M204 antibody | | 著者 | Abskharon, R, Sawaya, M.R, Seidler, P.M, Cascio, D, Eisenberg, D.S. | | 登録日 | 2019-06-26 | | 公開日 | 2020-06-24 | | 最終更新日 | 2020-08-12 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease.
J.Biol.Chem., 295, 2020
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6PK8
 | | Antibody scFv-M204 dimeric state | | 分子名称: | SULFATE ION, scFv-M204 antibody | | 著者 | Abskharon, R, Sawaya, M.R, Seidler, P.M, Cascio, D, Eisenberg, D.S. | | 登録日 | 2019-06-28 | | 公開日 | 2020-06-24 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.91 Å) | | 主引用文献 | Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease.
J.Biol.Chem., 295, 2020
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6PEO
 | | Cryo-EM structure of alpha-synuclein H50Q Narrow Fibril | | 分子名称: | Alpha-synuclein | | 著者 | Boyer, D.R, Li, B, Sawaya, M.R, Jiang, L, Eisenberg, D.S. | | 登録日 | 2019-06-20 | | 公開日 | 2019-11-27 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structures of fibrils formed by alpha-synuclein hereditary disease mutant H50Q reveal new polymorphs.
Nat.Struct.Mol.Biol., 26, 2019
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6PSC
 | | Antibody scFv-M204 trimeric state | | 分子名称: | scFv-M204 antibody | | 著者 | Abskharon, R, Sawaya, M.R, Seidler, P.M, Cascio, D, Eisenberg, D.S. | | 登録日 | 2019-07-12 | | 公開日 | 2020-06-17 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease.
J.Biol.Chem., 295, 2020
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6C3G
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6C3F
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6C88
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1F0V
 | | Crystal structure of an Rnase A dimer displaying a new type of 3D domain swapping | | 分子名称: | 5'-D(*CP*G)-3', GLYCEROL, PHOSPHATE ION, ... | | 著者 | Liu, Y.S, Gotte, G, Libonati, M, Eisenberg, D.S. | | 登録日 | 2000-05-17 | | 公開日 | 2001-02-21 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | A domain-swapped RNase A dimer with implications for amyloid formation
Nat.Struct.Biol., 8, 2001
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5CYU
 | | Structure of the soluble domain of EccB1 from the Mycobacterium smegmatis ESX-1 secretion system. | | 分子名称: | Conserved membrane protein | | 著者 | Arbing, M.A, Chan, S, Kahng, S, Kim, J, Eisenberg, D.S, TB Structural Genomics Consortium (TBSGC) | | 登録日 | 2015-07-30 | | 公開日 | 2015-08-12 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.07 Å) | | 主引用文献 | Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system.
Bmc Struct.Biol., 16, 2016
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5V5B
 | | KVQIINKKLD, Structure of the amyloid spine from microtubule associated protein tau Repeat 2 | | 分子名称: | Microtubule-associated protein tau | | 著者 | Seidler, P.M, Sawaya, M.R, Rodriguez, J.A, Eisenberg, D.S, Cascio, D, Boyer, D.R. | | 登録日 | 2017-03-13 | | 公開日 | 2018-02-07 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.5 Å) | | 主引用文献 | Structure-based inhibitors of tau aggregation.
Nat Chem, 10, 2018
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5V5C
 | | VQIINK, Structure of the amyloid-spine from microtubule associated protein tau Repeat 2 | | 分子名称: | Microtubule-associated protein tau | | 著者 | Seidler, P.M, Sawaya, M.R, Rodriguez, J.A, Eisenberg, D.S, Cascio, D, Boyer, D.R. | | 登録日 | 2017-03-14 | | 公開日 | 2018-02-07 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.25 Å) | | 主引用文献 | Structure-based inhibitors of tau aggregation.
Nat Chem, 10, 2018
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3RUB
 | | CRYSTAL STRUCTURE OF THE UNACTIVATED FORM OF RIBULOSE-1,5-BISPHOSPHATE CARBOXYLASE(SLASH)OXYGENASE FROM TOBACCO REFINED AT 2.0-ANGSTROMS RESOLUTION | | 分子名称: | ASPARAGINE, RIBULOSE 1,5-BISPHOSPHATE CARBOXYLASE/OXYGENASE, FORM III, ... | | 著者 | Schreuder, H, Cascio, D, Curmi, P.M.G, Chapman, M.S, Suh, S.W, Eisenberg, D.S. | | 登録日 | 1990-05-25 | | 公開日 | 1992-10-15 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of the unactivated form of ribulose-1,5-bisphosphate carboxylase/oxygenase from tobacco refined at 2.0-A resolution.
J.Biol.Chem., 267, 1992
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4R0U
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4R0P
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4R0W
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4RIK
 | | Amyloid forming segment, AVVTGVTAV, from the NAC domain of Parkinson's disease protein alpha-synuclein, residues 69-77 | | 分子名称: | Alpha-synuclein | | 著者 | Guenther, E.L, Sawaya, M.R, Ivanova, M, Eisenberg, D.S. | | 登録日 | 2014-10-06 | | 公開日 | 2015-08-26 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.854 Å) | | 主引用文献 | Structure of the toxic core of alpha-synuclein from invisible crystals.
Nature, 525, 2015
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4RIL
 | | Structure of the amyloid forming segment, GAVVTGVTAVA, from the NAC domain of Parkinson's disease protein alpha-synuclein, residues 68-78, determined by electron diffraction | | 分子名称: | Alpha-synuclein | | 著者 | Rodriguez, J.A, Ivanova, M, Sawaya, M.R, Cascio, D, Reyes, F, Shi, D, Johnson, L, Guenther, E, Sangwan, S, Hattne, J, Nannenga, B, Brewster, A.S, Messerschmidt, M, Boutet, S, Sauter, N.K, Gonen, T, Eisenberg, D.S. | | 登録日 | 2014-10-06 | | 公開日 | 2015-08-26 | | 最終更新日 | 2023-09-20 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.43 Å) | | 主引用文献 | Structure of the toxic core of alpha-synuclein from invisible crystals.
Nature, 525, 2015
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6AS9
 | | Filamentous Assembly of Green Fluorescent Protein Supported by a C-terminal fusion of 18-residues, viewed in space group P212121 form 2 | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, Green fluorescent protein | | 著者 | Sawaya, M.R, Heller, D.M, McPartland, L, Hochschild, A, Eisenberg, D.S. | | 登録日 | 2017-08-23 | | 公開日 | 2018-05-30 | | 最終更新日 | 2019-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Atomic insights into the genesis of cellular filaments by globular proteins.
Nat. Struct. Mol. Biol., 25, 2018
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6B79
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6BCS
 | | LilrB2 D1D2 domains complexed with benzamidine | | 分子名称: | BENZAMIDINE, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | | 著者 | Cao, Q, Sawaya, M.R, Eisenberg, D.S. | | 登録日 | 2017-10-20 | | 公開日 | 2018-09-05 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Inhibiting amyloid-beta cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design.
Nat Chem, 10, 2018
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6BWZ
 | | SYSGYS from low-complexity domain of FUS, residues 37-42 | | 分子名称: | SYSGYS peptide from low-complexity domain of FUS | | 著者 | Hughes, M.P, Rodriguez, J.A, Sawaya, M.R, Cascio, D, Tamir, G, Eisenberg, D.S. | | 登録日 | 2017-12-15 | | 公開日 | 2018-04-04 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Atomic structures of low-complexity protein segments reveal kinked beta sheets that assemble networks.
Science, 359, 2018
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6C3T
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