6NK4
 
 | |
6UFR
 | | Structure of recombinantly assembled E46K alpha-synuclein fibrils | | 分子名称: | Alpha-synuclein | | 著者 | Eisenberg, D.S, Boyer, D.R, Sawaya, M.R, Li, B, Jiang, L. | | 登録日 | 2019-09-24 | | 公開日 | 2020-02-19 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | The alpha-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure.
Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
8DU2
 | | HnRNPA2 D290V LCD PM1 | | 分子名称: | Heterogeneous nuclear ribonucleoproteins A2/B1 | | 著者 | Eisenberg, D.S, Lu, J, Ge, P, Boyer, D.R. | | 登録日 | 2022-07-26 | | 公開日 | 2023-08-02 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation.
J.Biol.Chem., 300, 2023
|
|
8DUW
 | | HnRNPA2 D290V LCD PM2 | | 分子名称: | Heterogeneous nuclear ribonucleoproteins A2/B1 | | 著者 | Eisenberg, D.S, Lu, J, Ge, P, Boyer, D.R. | | 登録日 | 2022-07-27 | | 公開日 | 2023-08-02 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation.
J.Biol.Chem., 300, 2023
|
|
8EC7
 | | HnRNPA2 D290V LCD PM3 | | 分子名称: | Heterogeneous nuclear ribonucleoproteins A2/B1 | | 著者 | Eisenberg, D.S, Lu, J, Ge, P, Boyer, D.R. | | 登録日 | 2022-09-01 | | 公開日 | 2023-09-06 | | 最終更新日 | 2024-02-14 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation.
J.Biol.Chem., 300, 2023
|
|
2GLS
 | |
6ODG
 | | SVQIVY, Crystal Structure of a tau protein fragment | | 分子名称: | Microtubule-associated protein tau | | 著者 | Eisenberg, D.S, Boyer, D.R, Sawaya, M.R, Seidler, P.M. | | 登録日 | 2019-03-26 | | 公開日 | 2019-10-02 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1 Å) | | 主引用文献 | Structure-based inhibitors halt prion-like seeding by Alzheimer's disease-and tauopathy-derived brain tissue samples.
J.Biol.Chem., 294, 2019
|
|
6N4P
 | |
2MLT
 | |
2ERL
 | | PHEROMONE ER-1 FROM | | 分子名称: | ETHANOL, MATING PHEROMONE ER-1 | | 著者 | Anderson, D.H, Weiss, M.S, Eisenberg, D. | | 登録日 | 1995-12-20 | | 公開日 | 1996-07-11 | | 最終更新日 | 2017-11-29 | | 実験手法 | X-RAY DIFFRACTION (1 Å) | | 主引用文献 | A challenging case for protein crystal structure determination: the mating pheromone Er-1 from Euplotes raikovi.
Acta Crystallogr.,Sect.D, 52, 1996
|
|
3T4G
 | | AIIGLMV segment from Alzheimer's Amyloid-Beta displayed on 54-membered macrocycle scaffold | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Cyclic pseudo-peptide (ORN)AIIGLMV(ORN)KF(HAO)(4BF)K | | 著者 | Zhao, M, Liu, C, Cheng, P.N, Eisenberg, D, Nowick, J.S. | | 登録日 | 2011-07-26 | | 公開日 | 2012-10-31 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Amyloid beta-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity.
Nat Chem, 4, 2012
|
|
3FTH
 | |
3FTK
 | |
6NB9
 | | Amyloid-Beta (20-34) with L-isoaspartate 23 | | 分子名称: | Amyloid-beta A4 protein | | 著者 | Sawaya, M.R, Warmack, R.A, Boyer, D.R, Zee, C.T, Richards, L.S, Cascio, D, Gonen, T, Clarke, S.G, Eisenberg, D.S. | | 登録日 | 2018-12-06 | | 公開日 | 2019-08-07 | | 最終更新日 | 2022-09-07 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.05 Å) | | 主引用文献 | Structure of amyloid-beta (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface.
Nat Commun, 10, 2019
|
|
5DBN
 | | Crystal structure of AtoDA complex | | 分子名称: | Acetate CoA-transferase subunit alpha, Acetate CoA-transferase subunit beta, CHLORIDE ION, ... | | 著者 | Arbing, M.A, Koo, C.W, Shin, A, Medrano-Soto, A, Eisenberg, D. | | 登録日 | 2015-08-21 | | 公開日 | 2016-08-24 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.549 Å) | | 主引用文献 | Crystal structure of AtoDA complex
To Be Published
|
|
5CCA
 | | Crystal structure of Mtb toxin | | 分子名称: | Endoribonuclease MazF3 | | 著者 | Cascio, D, Arbing, M, de Serrano, V, Eisenberg, D, Miallau, L, TB Structural Genomics Consortium (TBSGC) | | 登録日 | 2015-07-01 | | 公開日 | 2016-09-07 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Crystal structure of Mtb toxin
To Be Published
|
|
8FQ7
 | | Nanobody with WIW inserted in CDR3 loop to Inhibit Growth of Alzheimer's Tau fibrils | | 分子名称: | GLYCEROL, Nanobody with WIW insert in CDR3 loop to target tau fibrils | | 著者 | Abskharon, R, Sawaya, M.R, Cascio, D.C, Eisenberg, D.S. | | 登録日 | 2023-01-05 | | 公開日 | 2023-10-04 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils.
Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
4QX3
 | | Cry3A Toxin structure obtained by injecting Bacillus thuringiensis cells in an XFEL beam, collecting data by serial femtosecond crystallographic methods and processing data with the CrystFEL software suite | | 分子名称: | Pesticidal crystal protein cry3Aa | | 著者 | Sawaya, M.R, Cascio, D, Gingery, M, Rodriguez, J, Goldschmidt, L, Colletier, J.-P, Messerschmidt, M, Boutet, S, Koglin, J.E, Williams, G.J, Brewster, A.S, Nass, K, Hattne, J, Botha, S, Doak, R.B, Shoeman, R.L, DePonte, D.P, Park, H.-W, Federici, B.A, Sauter, N.K, Schlichting, I, Eisenberg, D. | | 登録日 | 2014-07-17 | | 公開日 | 2014-08-13 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Protein crystal structure obtained at 2.9 angstrom resolution from injecting bacterial cells into an X-ray free-electron laser beam.
Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
4QX2
 | | Cry3A Toxin structure obtained by injecting Bacillus thuringiensis cells in an XFEL beam, collecting data by serial femtosecond crystallographic methods and processing data with the cctbx.xfel software suite | | 分子名称: | Pesticidal crystal protein cry3Aa | | 著者 | Sawaya, M.R, Cascio, D, Gingery, M, Rodriguez, J, Goldschmidt, L, Colletier, J.-P, Messerschmidt, M, Boutet, S, Koglin, J.E, Williams, G.J, Brewster, A.S, Nass, K, Hattne, J, Botha, S, Doak, R.B, Shoeman, R.L, DePonte, D.P, Park, H.-W, Federici, B.A, Sauter, N.K, Schlichting, I, Eisenberg, D. | | 登録日 | 2014-07-17 | | 公開日 | 2014-08-13 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Protein crystal structure obtained at 2.9 angstrom resolution from injecting bacterial cells into an X-ray free-electron laser beam.
Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
4QX1
 | | Cry3A Toxin structure obtained by Serial Femtosecond Crystallography from in vivo grown crystals isolated from Bacillus thuringiensis and data processed with the CrystFEL software suite | | 分子名称: | Pesticidal crystal protein cry3Aa | | 著者 | Sawaya, M.R, Cascio, D, Gingery, M, Rodriguez, J, Goldschmidt, L, Colletier, J.-P, Messerschmidt, M, Boutet, S, Koglin, J.E, Williams, G.J, Brewster, A.S, Nass, K, Hattne, J, Botha, S, Doak, R.B, Shoeman, R.L, DePonte, D.P, Park, H.-W, Federici, B.A, Sauter, N.K, Schlichting, I, Eisenberg, D. | | 登録日 | 2014-07-17 | | 公開日 | 2014-08-13 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Protein crystal structure obtained at 2.9 angstrom resolution from injecting bacterial cells into an X-ray free-electron laser beam.
Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
4QXX
 | |
1LGR
 | |
4R0P
 | |
1LOJ
 | | Crystal structure of a Methanobacterial Sm-like archaeal protein (SmAP1) bound to uridine-5'-monophosphate (UMP) | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, URIDINE, URIDINE-5'-MONOPHOSPHATE, ... | | 著者 | Mura, C, Kozhukhovsky, A, Eisenberg, D. | | 登録日 | 2002-05-06 | | 公開日 | 2003-03-25 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The oligomerization and ligand-binding properties of Sm-like archaeal proteins (SmAPs)
Protein Sci., 12, 2003
|
|
4XFN
 | |
